Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2

Moran, Corey S.; Biroš, Erik; Krishna, Smriti Murali; Wang, Yutang; Tikellis, Chris; Morton, Sarah; Moxon, Joseph V.; Cooper, Mark E.; Norman, Paul; Burrell, Louise M.; Thomas, Merlin C.; Golledge, Jonathan

doi:10.1161/atvbaha.117.310129

Cited by 69 publications

(67 citation statements)

References 54 publications

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“…Many studies used apolipoprotein E deficient mice to explore mechanisms of AngII-induced AAAs (a few examples from a large number of publications 2,[18][19][20][21][22] ). This hypercholesterolemic mouse strain is modestly hypercholesterolemic and does not need Western diet to accelerate AngII-induced AAAs.…”

Section: Discussionmentioning

confidence: 99%

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

Liu

Sawada

Howatt

et al. 2020

Preprint

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Section: Discussionmentioning

confidence: 99%

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

Liu

Sawada

Howatt

et al. 2020

Preprint

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“…1). This hypothesis is supported by the abovementioned research demonstrating 1) that ACE2 plays a key role in SARS-CoV disease progression (18) and 2) the impact of diet on ACE2 expression and function (11,13,24,28,30,38,41). This may help to explain the vast interindividual variability observed in SARS-CoV-2 illness severity in humans (21).…”

Section: E831mentioning

confidence: 68%

“…Impact of dietary intake on ACE2 activity. With a lack of studies in humans [with the exception of one in vitro study in human aortic cells (28)], animal models inform our current knowledge base related to the impact of dietary factors on ACE2. ACE2 activity appears to be responsive to dietary fat and resveratrol, as further detailed below.…”

Section: Biological Plausibility For Gene-diet Interactionsmentioning

confidence: 99%

“…Therefore, the addition of dietary resveratrol may help to mitigate the detrimental impacts of high-fat diets on ACE2 gene expression (30). Last, an in vitro study using human aortic smooth muscle cells demonstrated that incubation of cells with resveratrol for 24 h significantly increased ACE2 gene and protein expression (28).…”

Section: Biological Plausibility For Gene-diet Interactionsmentioning

confidence: 99%

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Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity

Horne

Vohl

2020

American Journal of Physiology-Endocrinology and Metabolism

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Horne JR, Vohl MC. Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity. The angiotensin converting enzyme-2 (ACE2) cellular receptor is responsible for the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.

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“…Atherosclerotic vascular lesions may also be affected by the antioxidant effects of diet; however, data on dietary habits were not available in our study cohort. Another limitation of the present study was the non‐randomized, case‐control, single‐center design of the study.…”

Section: Discussionmentioning

confidence: 99%

Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms

Rafouli‐Stergiou

Ikonomidis

Katsiki

et al. 2020

J of Clinical Hypertension

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Pulse wave velocity (PWV) is a valid, clinically feasible marker of arterial stiffening, and a strong predictor of outcomes. The present study aimed to compare aortic elastic properties in patients with abdominal aortic aneurysms (AAA), with or without coronary artery disease (CAD), as well as healthy individuals. A total of 130 patients with AAA, eligible for interventional repair, and 30 healthy individuals, comprising the control group (HC), were enrolled. Presence of CAD was identified by coronary angiography. Aortic PWV (aPWV) was measured using the Arteriograph. aPWV was found considerably higher in AAA patients compared with HC group (11.5 ± 2.9 vs 7.3 ± 1.6 m/s, P < .001). Importantly, among patients with AAA, those with concomitant CAD (n = 41) had greater aPWV than those without CAD (12.5 ± 2.9 vs 11.0 ± 3.0 m/s, P = .03). In receiver operator curve (ROC) analysis, a value of aPWV above 12.8 m/s was identified to correlate with the presence of CAD in the AAA patient population. After adjustment for confounders, including hypertension which is one of the major risk factors for abdominal aneurysms, multivariate logistic regression analysis revealed that this aPWV cutoff remained independently associated with presence of CAD [odds ratio = 1.64, 95% confidence interval =1.19‐4.08, P = .03]. The coexistence of CAD and AAA is characterized by a greater arterial stiffness. This finding should be taken into consideration when selecting endovascular stents with more favorable elastic properties. Moreover, AAA patients with high aPWV (>12.8 m/s) are more likely to also have CAD, and this may be considered by vascular surgeons when evaluating patients' cardiovascular risk.

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Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2

Abstract: This study provides experimental evidence of an important role for ACE2 in limiting AAA development and growth. Resveratrol upregulated ACE2 and inhibited AAA growth in a mouse model.

Cited by 69 publications

References 54 publications

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms

Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity

Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms

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