Resveratrol inhibits glucose‐induced migration of vascular smooth muscle cells mediated by focal adhesion kinase

Lin, Yi‐Chiao; Chen, Li-Hsuen; Thiyagarajan, Varadharajan; Tsai, Ming-Tzu; Chia, Yi‐Chen; Yuan, Ta‐Chun; Sung, Ping‐Jyun; Weng, Ching‐Feng

doi:10.1002/mnfr.201300698

Cited by 33 publications

(24 citation statements)

References 53 publications

(50 reference statements)

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“…Recent studies further confirmed that resveratrol from red wine polyphenols could inhibit VSMC proliferation by suppressing ROS generation and inhibit VSMC migration by reducing MMPs expression. [20][21][22] Consistent with these experimental findings, we found that Chinese rice wine polyphenols could inhibit the proliferation and migration of VSMC. Interestingly, unlike red wine, we found that polypeptide in the Chinese rice wine could also inhibit the proliferation and migration of VSMC although its effect was weaker than that of the polyphenols.…”

Section: Discussionsupporting

confidence: 81%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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The beneficial effect of Chinese rice wine on atherosclerosis has been proved, but the exact components that have the cardiovascular protective effect are still unknown. This study aimed to explore the exact ingredients in Chinese rice wine that could inhibit homocysteine (Hcy)-induced vascular smooth muscle cell (VSMC) proliferation and migration. VSMCs were divided into 7 groups: control, Hcy (1 mmol/L), Hcy + oligosaccharide, Hcy + polypeptides, Hcy + polyphenols, Hcy + alcohol, and Hcy + Chinese rice wine. methyl thiazolyl tetrazolium (MTT) assay, Transwell chambers, and wound-healing assay were used to test the proliferation and migratory ability of the VSMCs. Western blot and gelatin zymography were used to investigate the expressions and activities of metal matrix proteinase 2/9 (MMP-2/9) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in VSMCs. Polypeptides and polyphenols in the Chinese rice wine reduced the proliferation and migration ability of the VSMCs. Furthermore, they also decreased the expression and activity of MMP-2/9 but had no obvious impact on the expression of TIMP-2 in each group. This study further confirms that polypeptides and polyphenols in the Chinese rice wine could inhibit Hcy-induced proliferation and migration of VSMCs and maintain the balance between matrix metalloproteinases (MMPs) and TIMPs.

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Section: Discussionsupporting

confidence: 81%

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Meng

Liu

Zhou

et al. 2016

Journal of Cardiovascular Pharmacology

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“…Importantly, resveratrol has been shown to suppress both VSMCs migration [118][119][120], and proliferation [121][122][123][124]. In addition, resveratrol has been shown to inhibit neointimal cell proliferation after vascular injury in an eNOS-dependent mechanism [125].…”

Section: Preclinical Studiesmentioning

confidence: 99%

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Zordoky

Robertson

Dyck

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

271

217

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Cardiovascular disease is the leading cause of death worldwide. Despite advancements in diagnosis and treatment of cardiovascular disease, the incidence of cardiovascular disease is still rising. Therefore, new lines of medications are needed to treat the growing population of patients with cardiovascular disease. Although the majority of the existing pharmacotherapies for cardiovascular disease are synthesized molecules, natural compounds, such as resveratrol, are also being tested. Resveratrol is a non-flavonoid polyphenolic compound, which has several biological effects. Preclinical studies have provided convincing evidence that resveratrol has beneficial effects in animal models of hypertension, atherosclerosis, stroke, ischemic heart disease, arrhythmia, chemotherapy-induced cardiotoxicity, diabetic cardiomyopathy, and heart failure. Although not fully delineated, some of the beneficial cardiovascular effects of resveratrol are mediated through activation of silent information regulator 1 (SIRT1), AMP-activated protein kinase (AMPK), and endogenous anti-oxidant enzymes. In addition to these pathways, the anti-inflammatory, anti-platelet, insulin-sensitizing, and lipid-lowering properties of resveratrol contribute to its beneficial cardiovascular effects. Despite the promise of resveratrol as a treatment for numerous cardiovascular diseases, the clinical studies for resveratrol are still limited. In addition, several conflicting results from trials have been reported, which demonstrates the challenges that face the translation of the exciting preclinical findings to humans. Herein, we will review much of the preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular disease and provide information about the physiological and molecular signaling mechanisms involved. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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“…Long-term high glucose exposure can lead to various complications such as atherosclerosis and diabetic cerebrovascular diseases [2]. Vascular lesions are the main complications of diabetes and the primary reason for death caused by diabetes [3]. Pathological and physiological changes caused by high glucose such as oxidative stress, activation of sorbitol bypass metabolic abnormalities, and decreased mitochondrial biogenesis, are associated with endothelial dysfunction [4].…”

Section: Introductionmentioning

confidence: 99%

CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation

Lü

et al. 2016

Biochemical and Biophysical Research Communications

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Resveratrol inhibits glucose‐induced migration of vascular smooth muscle cells mediated by focal adhesion kinase

Cited by 33 publications

References 53 publications

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Polyphenols and Polypeptides in Chinese Rice Wine Inhibit Homocysteine-induced Proliferation and Migration of Vascular Smooth Muscle Cells

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation

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