Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis

Liang, Feiyu; Xiao-zuo, XU; Tu, Yanyan

doi:10.1016/j.bmc.2021.116593

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…In patients with type 2 diabetes, the miR-190a-5p was associated with the risk of developing diabetic retinopathy 41 In animal models, miR-190a-5p expression levels were higher in liver tissues of mice with liver fibrosis than in their respective controls. 42 We observed significant differences in mean expression levels of miR-142-3p between children with obesity and with and without IR, in agreement with previous findings in adults 43,44 and children. 21 In a sample of 250 school children, Al-rawaf et al studied the association of specific miRNAs with different parameters associated with metabolic syndrome and reported higher levels of circulating miR-142 in those with higher HOMA-IR.…”

Section: Discussionsupporting

confidence: 92%

“…We also found that the circulating miR‐190a‐5p levels were consistently higher in children with IR independently of their weight status and that it was significantly correlated with HOMA‐IR. In patients with type 2 diabetes, the miR‐190a‐5p was associated with the risk of developing diabetic retinopathy 41 In animal models, miR‐190a‐5p expression levels were higher in liver tissues of mice with liver fibrosis than in their respective controls 42 …”

Section: Discussionmentioning

confidence: 99%

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Peripheral blood mononuclear cells‐expressed miRNA profiles derived from children with metabolic‐associated fatty liver disease and insulin resistance

Osés

Medrano

Sanchez³

et al. 2022

Pediatric Obesity

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Background: miRNA have been proposed as potential biomarkers of metabolic diseases.Objectives: To identify potential miRNA biomarkers of early metabolic-associated fatty liver disease (MAFLD) and/or insulin resistance (IR) in preadolescent children.Methods: A total of 70 preadolescents, aged 8.5-12 years old participated in the study. Hepatic fat was assessed by magnetic resonance imaging. Fasting blood biochemical parameters were measured and HOMA-IR calculated. Peripheral blood mononuclear cells (PBMC)-derived miRNA profiles associated with MAFLD (≥5.5% hepatic fat) and IR (HOMA-IR ≥2.5) were identified using untargeted high-throughput miRNAs sequencing (RNA-seq).Results: A total of 2123 PBMC-derived miRNAs were identified in children with (21.4%) or without MAFLD. Among them, hsa-miR-143-3p, hsa-miR-142-5p and hsa-miR-660-5p were up-regulated, and p-hsa-miR-247, hsa-let-7a-5p and hsa-miR-6823-3p down-regulated. Importantly, children with MAFLD had consistently higher miR-660-5p expression levels than their peers without it (p < 0.01), regardless of weight status. A total of 2124 PBMC-derived miRNA were identified in children with

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Peripheral blood mononuclear cells‐expressed miRNA profiles derived from children with metabolic‐associated fatty liver disease and insulin resistance

Osés

Medrano

Sanchez³

et al. 2022

Pediatric Obesity

View full text Add to dashboard Cite

show abstract

“…In a similar recent study, RSV was found to inhibit TAA-induced hepatotoxicity and liver fibrosis through inhibition of TAA-induced upregulation of TNF-α, nuclear factor-kB, and the profibrotic biomarkers (Ebrahim et al,2022). Further, in-vivo experiments on the TAA model assured that RSV administration decreased serum levels of transaminases and raised serum albumin levels (Liang et al,2022).…”

Section: Figmentioning

confidence: 76%

“…In line with the assumed role of RSV prophylaxis through manipulation with expression levels of microRNAs, an animal model of RSV prophylaxis in acute liver injury reported that RSV protection was associated with inhibition of TGFβ1-Smad3-miR21 axis, and inflammatory and profibrotic cytokines (ShamsEldeen et al,2021). Thereafter, another study detected a reduction of hepatocyte apoptosis with RSV administration and attributed this effect to decreasing the expression levels of miR-190a-5p and increasing the in-vitro expression of hepatocyte growth factor (Liang et al,2022).…”

Section: Figmentioning

confidence: 93%

Prophylactic Resveratrol Ameliorates Thioacetamide Hepatotoxicity in A Dose-Dependent Fashion Through the Regulation of Gene Expression Levels of MiR-155 and MiR-21

Elnajjar

Abdelrahman²,

Marei³

et al. 2022

Egyptian Academic Journal of Biological Sciences, F. Toxicology

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“…In patients with T2D, the miR-190a-5p was associated with the risk of developing diabetic retinopathy (172). In animal models, miR-190a-5p expression levels were higher in liver tissues of mice with liver fibrosis than in their respective controls (173).…”

Section: Potential Mirna Biomarkers Of Early Mafld And/or Ir In Pread...mentioning

confidence: 87%

Identification of sociodemographic, biochemical and epigenetic biomarkers of hepatic steatosis in children with overweight or obesity

Osés¹

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Childhood obesity is one of the 21st century's most serious public health challenges, becoming in the most prevalent cardiometabolic disease. In the last two decades, in parallel with the childhood obesity epidemic, several associated comorbidities such as cardiovascular diseases, type 2 diabetes (T2D) and metabolic associated fatty liver disease (MAFLD) have raised in paediatric population. MAFLD has emerged as one of the most serious comorbidities of childhood obesity, and the most common cause of chronic liver disease among children and young adults worldwide. MAFLD encompasses a spectrum of diseases ranging from steatosis to steatohepatitis, fibrosis and eventually cirrhosis, worsening and complicating the stage and the reversibility of the disease. The asymptomatic evolution of MAFLD, together with its high prevalence and costly and/or invasive diagnosis methods (liver biopsy and/or magnetic resonance imaging) make difficult the early identification of children with the disease. Paediatric MAFLD development and progression mechanisms are complex and multifactorial. Specific genetic polymorphisms and epigenetic modifications, sociodemographic and lifestyle factors have been associated with the development of the disease. The identification of risk factors for paediatric MAFLD development and the study of potential biomarkers for its diagnosis is crucial for its early prevention and treatment. Thus, there is agreement among scientific/medical associations on the need to develop useful screening tools to detect paediatric MAFLD. Therefore, the overall objectives of the present International Doctoral Thesis were: i) to develop a minimally invasive screening protocol with high predictive potential for the identification of children with overweight or obesity candidates to confirmatory diagnosis of MAFLD that can be useful in clinical practice ii) to systematically analyse the biomarker role of circulating miRNAs in the early onset of obesity and obesity associated co-morbidities through the examination of available circulating miRNA profile data in children and adolescents with obesity, and in obesity-associated metabolic abnormalities, and iii) to identify potential miRNA biomarkers of early MAFLD and/or IR in preadolescent children, and to test their associations with cardiometabolic risk factors. In order to achieve these objectives, data from the EFIGRO, PREDIKID and MICROKID investigation projects were considered. The conclusions from the current Thesis are: i) sociodemographic and lifestyle factors such as ethnic minority, prematurity at birth, elevated waist to height circumference ratio, sugar sweetened consumption, screen time and low cardiorespiratory fitness are consistently associated with the presence of hepatic steatosis in children with overweight or obesity, ii) at present, available screening methods for MAFLD identification in children have limited accuracy and applicability, iii) the HEPAKID index pre-screening tool is the first sociodemographic, lifestyle and anthropometric data-based screening method for identifying children with overweight or obesity whit elevated risk to suffer hepatic steatosis, iv) biochemical parameters such as, plasma TG, insulin, HOMA-IR, AST, ALT, GGT and ferritin levels, as well as the presence of risk alleles of PPARGrs13081389, PPARGrs1801282, HFErs1800562 and PNLPLA3rs4823173 polymorphisms, are consistently associated with the presence of hepatic steatosis in children with overweight or obesity. However, their prediction capacity is not enough for the screening of MAFLD, v) the HEPAKID prediction protocol identifies with high sensitivity, specificity and accuracy, as well as low time-consuming and economic cost, children with overweight or obesity who likely suffer from MAFLD, and who should be referred for confirmatory diagnosis, vi) circulating miRNAs could be promising diagnostic biomarkers of obesity-associated diseases, such as MAFLD and T2D, already in childhood. However, it was not possible to identify a concrete miRNA profile in children with obesity in the literature, vii) circulating miR-660-5p seems to be a biomarker of the presence of MAFLD in preadolescent children, regardless of weight status, and viii) circulating miR-320a, miR-142-3p, miR-190a-5p, miR-374a-5p and let-7 family miRNAs could serve as potential biomarkers of IR in children.

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Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis

Cited by 18 publications

References 24 publications

Peripheral blood mononuclear cells‐expressed miRNA profiles derived from children with metabolic‐associated fatty liver disease and insulin resistance

Peripheral blood mononuclear cells‐expressed miRNA profiles derived from children with metabolic‐associated fatty liver disease and insulin resistance

Prophylactic Resveratrol Ameliorates Thioacetamide Hepatotoxicity in A Dose-Dependent Fashion Through the Regulation of Gene Expression Levels of MiR-155 and MiR-21

Identification of sociodemographic, biochemical and epigenetic biomarkers of hepatic steatosis in children with overweight or obesity

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