Resveratrol‐induced remodelling of myocellular lipid stores: A study in metabolically compromised humans

Polanen, Nynke van; Zacharewicz, Evelyn; Ligt, Marlies de; Timmers, Silvie; Moonen‐Kornips, Esther; Schaart, Gert; Hoeks, Joris; Schrauwen, Patrick; Hesselink, Matthijs K.C.

doi:10.14814/phy2.14692

Cited by 3 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rodents, RSV blunted high-fat diet (HFD)-induced hepatic lipid storage and metabolic disorders ( Alberdi et al, 2013 ; Zhou et al, 2018 ), muscle lipid storage ( Zhang Y. J. et al, 2019 ; Gong et al, 2020 ) and ameliorated insulin resistance ( Jeon et al, 2012 ; Zhang Y. J. et al, 2019 ; Gong et al, 2020 ). In human trials, it was also observed that glucose and lipids were improved after RSV treatment ( Bhatt et al, 2012 ; Hsu et al, 2020 ; Izquierdo et al, 2021 ; van Polanen et al, 2021 ), but our findings contradict the previous reports ( Sahebkar, 2013 ; Sahebkar et al, 2015 ; Timmers et al, 2016 ; Kjær et al, 2017 ; de Ligt et al, 2018 ; Tabrizi et al, 2020 ). Discrepancies among existing bodies of evidence might be linked to insufficient sample size and characteristics existing in study design, such as study populations, statistical analyses, comorbid conditions, and dosages and formulations of RSV used.…”

Section: Discussioncontrasting

confidence: 85%

“…The observed changes in lipid compositions potentially indicate altered expression of diseased states. In metabolically compromised humans, RSV induced remodeling of myocellular lipid stores ( van Polanen et al, 2021 ), reduced of lipid accumulation, and increased glycogen storage in muscle and hepatic cells by promoting lipolysis in adipocytes ( Gong et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

et al. 2022

View full text Add to dashboard Cite

BackgroundLipids are ubiquitous metabolites with diverse functions. Excessive lipid accumulation can trigger lipid redistribution among metabolic organs such as adipose, liver and muscle, thus altering the lipid metabolism. It has been revealed that disturbed lipid metabolism would cause multiple disease complications and is highly correlated with human morbidity. Resveratrol (RSV), a phytoestrogen with antioxidant, can modulate insulin resistance and lipid profile. Recently, research on RSV supplementation to improve glucose and lipid metabolism has been controversial. A meta-analysis may provide a scientific reference for the relationship between lipid metabolism and RSV supplementation.Methods and AnalysisWe searched the PubMed, Cochrane Library, Web of Science, and Embase databases from inception to October 2021 using relevant keywords. A comprehensive search for randomized controlled trials (RCTs) was performed. For calculating pooled effects, continuous data were pooled by mean difference (MD) and 95% confidence interval (CI). Adopting the method of inverse-variance with a random-effect, all related statistical analyses were performed using the Rev Man V.5.3 and STATA V.15 software.ResultsA total of 25 articles were incorporated into the final meta-analysis after removal of duplicates by checking titles and abstracts and excluding non-relevant articles. The selected articles had a total of 1,171 participants, including 578 in the placebo group and 593 in the intervention group. According to the current meta-analysis, which demonstrated that there was a significant decrease in waist circumference (SMD = –0.36; 95% CI: –0.59, –0.14; P = 0.002; I2 = 88%), hemoglobin A1c (–0.48; –0.69, –0.27; P ≤ 0.001; I2 = 94%), total cholesterol (–0.15; –0.3, –0.01; P = 0.003; I2 = 94%), low density lipoprotein cholesterol (–0.42; –0.57, –0.27; P ≤ 0.001; I2 = 92%), high density lipoprotein cholesterol (0.16; –0.31, –0.02; P = 0.03; I2 = 81%) following resveratrol administration.ConclusionThese results suggest that RSV has a dramatic impact on regulating lipid and glucose metabolism, and the major clinical value of resveratrol intake is for obese and diabetic patients. We hope that this study could provide more options for clinicians using RSV. Furthermore, in the future, large-scale and well-designed trials will be warranted to confirm these results.Systematic Review RegistrationWebsite [https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42021244904].

show abstract

Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Here, we show that the increased IMCL after dapagliflozin was due to both an increase in LD number as well as larger LDs. We have observed previously that an increase in IMCL content due to both LD number and size occurs with interventions increasing muscle fatty acid oxidation such as prolonged fasting [ 22 ] and resveratrol [ 48 ]. The increased IMCL storage capacity and LD size may therefore be reflective of altered LD dynamics similar to what is seen with fasting.…”

Section: Discussionmentioning

confidence: 99%

Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

Kamp¹,

Gemmink²,

Ligt³

et al. 2022

Molecular Metabolism

View full text Add to dashboard Cite

Resveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health

Toniolo,

Concato,

Giacomello

2023

Nutrients

View full text Add to dashboard Cite

Resveratrol is a natural polyphenol utilized in Chinese traditional medicine and thought to be one of the determinants of the “French Paradox”. More recently, some groups evidenced its properties as a calorie-restriction mimetic, suggesting that its action passes through the modulation of skeletal muscle metabolism. Accordingly, the number of studies reporting the beneficial effects of resveratrol on skeletal muscle form and function, in both experimental models and humans, is steadily increasing. Although studies on animal models confer to resveratrol a good potential to ameliorate skeletal muscle structure, function and performance, clinical trials still do not provide clear-cut information. Here, we first summarize the effects of resveratrol on the distinct components of the skeletal muscle, such as myofibers, the neuromuscular junction, tendons, connective sheaths and the capillary bed. Second, we review clinical trials focused on the analysis of skeletal muscle parameters. We suggest that the heterogeneity in the response to resveratrol in humans could depend on sample characteristics, treatment modalities and parameters analyzed; as well, this heterogeneity could possibly reside in the complexity of skeletal muscle physiology. A systematic programming of treatment protocols and analyses could be helpful to obtain consistent results in clinical trials involving resveratrol administration.

show abstract

Resveratrol‐induced remodelling of myocellular lipid stores: A study in metabolically compromised humans

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 57 publications

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review

Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

Resveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health

Contact Info

Product

Resources

About