Resveratrol improves the cytotoxic effect of CD8 +T cells in the tumor microenvironment by regulating HMMR/Ferroptosis in lung squamous cell carcinoma

Gao, Shan; Kang, Min-Hee; Jizhao, WANG; Zhao, Rui; Zhang, Guangjian; Zheng, Jin; Li, Meihe

doi:10.1016/j.jpba.2023.115346

Cited by 20 publications

(10 citation statements)

References 46 publications

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“…Research has demonstrated that resveratrol possesses antitumor, antioxidant, anti-inflammatory, and anti-apoptotic effects. This anti-apoptotic effect can be partially explained by its great potential to inhibit ferroptosis [ 111 , 175 , 180 , 307 , 319 ].…”

Section: Discussionmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease. Polyphenols, plant secondary metabolites known for many bioactivities, are being extensively researched in the context of their influence on ferroptosis which resulted in a great number of publications showing the need for a systematic review. In this review, an extensive literature search was performed. Databases (Scopus, Web of Science, PubMed, ScienceDirect, Springer) were searched in the time span from 2017 to November 2023, using the keyword “ferroptosis” alone and in combination with “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, and “chalcone”; after the selection of studies, we had 311 papers and 143 phenolic compounds. In total, 53 compounds showed the ability to induce ferroptosis, and 110 compounds were able to inhibit ferroptosis, and out of those compounds, 20 showed both abilities depending on the model system. The most researched compounds are shikonin, curcumin, quercetin, resveratrol, and baicalin. The most common modes of action are in the modulation of the Nrf2/GPX4 and Nrf2/HO-1 axis and the modulation of iron metabolism.

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Section: Discussionmentioning

confidence: 99%

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Živanović,

Lesjak,

Simin

et al. 2024

Antioxidants

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“…The vitamin D–active metabolite PRI-2191 was shown to cause a significant upregulation of PD-L1 expression in HCC 827 and NCI-H358 cells, and only when PRI-2191 was used with RESV was PD-L1 expression significantly increased ( 82 ). RESV can upregulate the cytotoxic effect of CD8+ T cells and improve the tumor immunosuppressive microenvironment, and the combination of RESV with other immunotherapy drugs may be a more effective treatment ( 83 ). RESV is considered to be a module of the inhibitory function of medullary-derived suppressor cells (MDSC), a novel booster of tumor immunotherapy.…”

Section: Effect Of Dietary Intervention On the Efficacy Of Immunother...mentioning

confidence: 99%

Gut microbiota and dietary intervention: affecting immunotherapy efficacy in non–small cell lung cancer

Xin,

Liu,

Zang

et al. 2024

Front. Immunol.

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Non–small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancers. In recent years, treatment with immune checkpoint inhibitors (ICIs) has gradually improved the survival rate of patients with NSCLC, especially those in the advanced stages. ICIs can block the tolerance pathways that are overexpressed by tumor cells and maintain the protective activity of immune system components against cancer cells. Emerging clinical evidence suggests that gut microbiota may modulate responses to ICIs treatment, possibly holding a key role in tumor immune surveillance and the efficacy of ICIs. Studies have also shown that diet can influence the abundance of gut microbiota in humans, therefore, dietary interventions and the adjustment of the gut microbiota is a novel and promising treatment strategy for adjunctive cancer therapy. This review comprehensively summarizes the effects of gut microbiota, antibiotics (ATBs), and dietary intervention on the efficacy of immunotherapy in NSCLC, with the aim of informing the development of novel strategies in NSCLC immunotherapy.

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“…In lung squamous cell carcinoma, it has been shown that SLC7A11 and CD168 are coexpressed frequently. Resveratrol through inhibiting the interaction between these two molecules could induce ferroptosis (Shan et al, 2023). In addition, NFS1, a crucial player in the synthesis of iron-sulfur clusters, plays a vital role in ensuring the survival of cancer cells in oxygen-rich conditions like lung tumors, acting as a safeguard against the occurrence of ferroptosis (Alvarez et al, 2017).…”

Section: Resveratrolmentioning

confidence: 99%

“…Cisplatin resistance also occurs in oral squamous cell carcinoma and indicating its potential as an immunotherapeutic agent. Thus, resveratrol could be a valuable addition to immunotherapy strategies for lung squamous cell carcinoma, offering new avenues for enhancing antitumor immune responses (Shan et al, 2023). Researchers may explore how natural products can specifically target and enhance the efficacy of different immunotherapeutic modalities, including cancer vaccines, immune checkpoint inhibitors, and adoptive immune-cell therapy.…”

Section: Carnosic Acidmentioning

confidence: 99%

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

Zhang,

Xie

2024

Phytotherapy Research

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In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form of regulated cell death characterized by iron‐dependent lipid peroxidation. This review delves into the roles of key natural phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis and their underlying mechanisms. Emphasizing the significance of amino acid, lipid, and iron metabolism, the study elucidates the diverse pathways through which these phenols regulate ferroptosis. Notably, curcumin, a well‐known polyphenol, exhibits multifaceted interactions with cellular components involved in ferroptosis regulation, providing a distinctive therapeutic avenue. Stilbenes, another phenolic class, demonstrate promising potential in influencing lipid metabolism and iron‐dependent processes, contributing to ferroptotic cell death. Understanding the intricate interplay between these natural phenols and ferroptosis not only illuminates complex cellular regulatory networks but also unveils potential avenues for novel cancer therapies. Exploring these compounds as inducers of ferroptosis presents a promising strategy for targeted cancer treatment, capitalizing on the delicate balance between cellular metabolism and regulated cell death mechanisms. This article synthesizes current knowledge, aiming to stimulate further research into the therapeutic potential of natural phenols in the context of ferroptosis‐mediated cancer therapy.

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Resveratrol improves the cytotoxic effect of CD8 +T cells in the tumor microenvironment by regulating HMMR/Ferroptosis in lung squamous cell carcinoma

Cited by 20 publications

References 46 publications

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

Gut microbiota and dietary intervention: affecting immunotherapy efficacy in non–small cell lung cancer

Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy

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