Resveratrol improves in vitro maturation of oocytes in aged mice and humans

Liu, Meiju; Sun, Aigang; Zhao, Shigang; Liu, Hui; Ma, Shanshan; Mei, Li; Huai, Ying-Xue; Zhao, Han; Liu, Hongbin

doi:10.1016/j.fertnstert.2018.01.020

Cited by 86 publications

(73 citation statements)

References 30 publications

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“…Resveratrol has a therapeutic direct effect on oocytes in in vitro culture. Treating the culture media with resveratrol improves oocyte maturation and the developmental competence of embryos to blastocysts in both animals and humans . Moreover, during IVF treatments, minimization of the time‐dependent deterioration after ovulation (postovulatory oocyte aging) is a key for successful pregnancies.…”

Section: Impact On Ovary For Pregnancymentioning

confidence: 99%

“…Treating the culture media with resveratrol improves oocyte maturation and the developmental competence of embryos to blastocysts in both animals and humans. [40][41][42][43][44] Moreover, during IVF treatments, minimization of the time-dependent deterioration after ovulation (postovulatory oocyte aging) is a key for successful pregnancies. Resveratrol treatment can protect against postovulatory oocyte aging in vivo in middle-aged mice.…”

Section: In Vitro Maturation (Ivm) and Ivfmentioning

confidence: 99%

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Preconception resveratrol intake against infertility: Friend or foe?

Ochiai

Kuroda

2019

Reprod Medicine & Biology

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Background Resveratrol is an antiaging, antioxidant, anti‐inflammatory, and insulin‐sensitizing natural polyphenolic compound. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian function, polycystic ovary syndrome (PCOS), or endometriosis. However, only one clinical trial in women undergoing in vitro fertilization (IVF) cycles using resveratrol has ever been reported. This review focuses on the potential therapeutic effects of resveratrol on pregnancy and on its advantages and disadvantages in pregnancy outcomes during infertility treatment. Methods We performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium. Results Resveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2‐RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual‐related genes. Conclusions Resveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti‐deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.

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Section: Impact On Ovary For Pregnancymentioning

confidence: 99%

Section: In Vitro Maturation (Ivm) and Ivfmentioning

confidence: 99%

Preconception resveratrol intake against infertility: Friend or foe?

Ochiai

Kuroda

2019

Reprod Medicine & Biology

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“…2017, Liu et al, 2003. IVM is a standard procedure (Fesahat et al, 2017) which will be optimized for our conditions, by varying the culture drop size, the hours with cumulus cell attachment and cumulus cell co-culture, and the contents of the IVM media (Liu et al, 2018, Hirao et al, 2004. The conditions which result in maximum maturation rate in the control group will be used for in vitro maturation of GVs undergoing nuclear transfer.…”

Section: IImentioning

confidence: 99%

Clinical trial for the treatment of infertility due to poor oocyte quality

Zhang¹,

Zukin²,

Alexandrova³

et al. 2019

http://isrctn.com/

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“…In mammals, several in vitro and in vivo studies performed in male used a supplementation of natural antioxidants from plant origin as a means of counteracting the oxidative stress to improve fertility [8]. Even though fewer studies are available in the female, secondary metabolites from plants such as polyphenols have been reported to improve the number and quality of oocytes mice and humans [9,10].…”

Section: Introductionmentioning

confidence: 99%

A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens

et al. 2020

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In broiler hens, the genetic selection increased susceptibility to metabolic disorders and reproductive dysfunctions. In human ovarian cells, grape seed extracts (GSE) improved steroid production. Here, we investigated the effects of a GSE dietary supplementation on egg production and quality, fertility parameters, Reactive Oxygen Species (ROS) and steroid content in yolk egg associated to plasma adipokines in broiler hens. For this, we designed two in vivo experiments, the first one included three groups of hens: A (control), B and C (supplemented with GSE at 0.5% and 1% of the total diet composition, respectively, since week 4), and the second one used two groups of hens: A (control) and D (supplemented with GSE at 1% of the total diet composition since hatching). We assessed the egg production from 23 th to 40 th weeks and quality at 33 th week. After artificial inseminations, the fertility parameters were calculated. In egg yolk, Reactive Oxygen Species (ROS) level and steroid production were evaluated by Ros-Glo H202 and ELISA assay, respectively. Expression of steroidogenic enzymes and adipokines and their receptors was determined by RT-qPCR in ovarian cells and plasma adipokines (RARRES2, ADIPOQ and NAMPT) were evaluated by specific ELISA assays. The fertility parameters and egg production were unaffected by GSE supplementation whatever the experiment (exp.). However, the rate of double-yolk eggs decreased for all GSE supplemented groups (exp. 1 P <0.01, exp.2, P<0.02). In exp.1, C group eggs were bigger and larger (P<0.0001) and the shell elasticity was higher for both B and C (P<0.0003) as compared to control. In the egg yolk, GSE supplementation in both exp. reduced ROS content and steroidogenesis consistent with a decrease in P450 aromatase and StAR mRNA expression and basal in vitro progesterone secretion in granulosa cells (P<0.001). Interestingly, in both exp. RARRES2 plasma levels were positively

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Resveratrol improves in vitro maturation of oocytes in aged mice and humans

Cited by 86 publications

References 30 publications

Preconception resveratrol intake against infertility: Friend or foe?

Preconception resveratrol intake against infertility: Friend or foe?

Clinical trial for the treatment of infertility due to poor oocyte quality

A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens

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