Resveratrol Improves Diabetic Retinopathy via Regulating MicroRNA-29b/Specificity Protein 1/Apoptosis Pathway by Enhancing Autophagy
kaihong Zeng,
Zheng-Wei Wan,
Ping Sun
et al.
Abstract:Therapeutic targeting of retinal Müller cells (RMCs) has garnered tremendous attention for early prevention and treatment of diabetic retinopathy (DR). The microRNA-29b (miR-29b)/specificity protein 1 (SP1) pathway is critical for RMCs survival in hyperglycemic environments, and miR-29b downregulation and SP1 upregulation contribute to RMCs apoptosis during early DR stages. Resveratrol (RSV), a natural plant polyphenol, can inhibit RMCs apoptosis by regulating miR-29b/SP1 expression, playing an important role … Show more
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