Resveratrol glycoside mediates microglial endoplasmic reticulum stress to mitigate LPS-induced sepsis-associated cognitive dysfunction

Yin, Yilong; Lv, Guoguang; Zhang, Wang; Yuan, Jing; Yang, Yuekui; Wang, Yushui; Liu, Shuai; Wang, Shan; Yan, Binbin; Bai, Hai; Ye, Chaoqun

doi:10.1016/j.bbr.2023.114326

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…These findings indicate that NPCs undergo ER stress following exposure to deltamethrin, which potentially contributes to the reduction of hippocampal neurogenesis. These results are consistent with others showing ER stress-induced CHOP expression in different contexts [68,69]. Notably, a study involving mice with long-term obesity revealed ER stress and CHOP expression in DCX-expressing immature neurons, indicating a common mechanism of ER stress-related neurogenesis impairment [70].…”

Section: Discussionsupporting

confidence: 92%

The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice

Toltin,

Belkadi,

Gamba

et al. 2023

IJMS

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Environmental factors, including pesticide exposure, have been identified as substantial contributors to neurodegeneration and cognitive impairments. Previously, we demonstrated that repeated exposure to deltamethrin induces endoplasmic reticulum (ER) stress, reduces hippocampal neurogenesis, and impairs cognition in adult mice. Here, we investigated the potential relationship between ER stress and hippocampal neurogenesis following exposure to deltamethrin, utilizing both pharmacological and genetic approaches. To investigate whether ER stress is associated with inhibition of neurogenesis, mice were given two intraperitoneal injections of eIf2α inhibitor salubrinal (1 mg/kg) at 24 h and 30 min prior to the oral administration of deltamethrin (3 mg/kg). Salubrinal prevented hippocampal ER stress, as indicated by decreased levels of C/EBP-homologous protein (CHOP) and transcription factor 4 (ATF4) and attenuated deltamethrin-induced reductions in BrdU-, Ki-67-, and DCX-positive cells in the dentate gyrus (DG) of the hippocampus. To further explore the relationship between ER stress and adult neurogenesis, we used caspase-12 knockout (KO) mice. The caspase-12 KO mice exhibited significant protection against deltamethrin-induced reduction of BrdU-, Ki-67-, and DCX-positive cells in the hippocampus. In addition, deltamethrin exposure led to a notable upregulation of CHOP and caspase-12 expression in a significant portion of BrdU- and Ki-67-positive cells in WT mice. Conversely, both salubrinal-treated mice and caspase-12 KO mice exhibited a considerably lower number of CHOP-positive cells in the hippocampus. Together, these findings suggest that exposure to the insecticide deltamethrin triggers ER stress-mediated suppression of adult hippocampal neurogenesis, which may subsequently contribute to learning and memory deficits in mice.

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Section: Discussionsupporting

confidence: 92%

The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice

Toltin,

Belkadi,

Gamba

et al. 2023

IJMS

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“…Resveratrol can alleviate ERS in various ways to inhibit chondrocyte apoptosis. These common pathways include increasing the folding and modification of endoplasmic reticulum proteins, regulating endoplasmic reticulum-related signalling pathways, and inhibiting the occurrence of related inflammatory responses and oxidative stress responses [ 90 , 91 ]. Combining the previous studies with this meta-analysis, resveratrol is shown to have a positive effect on reducing cellular apoptosis including OA articular chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Effects of resveratrol on biochemical and structural outcomes in osteoarthritis: A systematic review and meta-analysis of preclinical studies

Zhao,

Zhu,

Wong

et al. 2024

Heliyon

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“…Yin et al. reported that resveratrol glycosides alleviated cognitive dysfunction in LPS‐induced SAE by inhibiting endoplasmic reticulum stress in microglia [85] . β‐Nincotinamide mononucleotide reduced the inflammatory response and oxidative stress in the hippocampus of septic mice via the nicotinamide adenine dinucleotide + /sirtuin 1 pathway, mitigating memory dysfunction and neuronal damage [86] .…”

Section: Sae Treatmentmentioning

confidence: 99%

Recent advances in the pathogenesis, diagnosis, and treatment of sepsis‐associated encephalopathy

Wang,

Bi,

Huang

et al. 2024

Brain-X

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Sepsis is a life‐threatening organ dysfunction syndrome caused by the host's dysregulated response to infection. The leading causes of death in critically ill patients are sepsis‐associated encephalopathy (SAE), respiratory dysfunction, circulatory dysfunction, and other multi‐organ dysfunctions. SAE is among the most common serious complications of sepsis and is associated with a poor prognosis and long‐term cognitive dysfunction. Its clinical manifestations vary, and there are still no unified diagnostic criteria. The incidence of SAE varies from 9% to 71% in critically ill patients due to therapeutic interventions such as sedation, mechanical ventilation, and muscle relaxants. Advances in medical technology have significantly increased the survival rate of patients with sepsis, but up to 21% now experience long‐term sequelae or cognitive impairment. The lack of specific early diagnostic and treatment methods leads to increased SAE‐associated mortality and complications in patients, which also impose heavy economic burdens. This article reviews the pathogenesis and diagnostic methods of SAE and progress in its treatment, aiming to reduce the mortality and hospitalization lengths of patients with SAE and improve their survival rate and quality of life through early detection, diagnosis, and effective treatment.

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Resveratrol glycoside mediates microglial endoplasmic reticulum stress to mitigate LPS-induced sepsis-associated cognitive dysfunction

Cited by 4 publications

References 41 publications

The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice

The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice

Effects of resveratrol on biochemical and structural outcomes in osteoarthritis: A systematic review and meta-analysis of preclinical studies

Recent advances in the pathogenesis, diagnosis, and treatment of sepsis‐associated encephalopathy

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