Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons

Madhyastha, Sampath; Sahu, Sudhanshu Sekhar; Rao, Gayathri M

doi:10.1515/jbcpp-2013-0011

Cited by 18 publications

(14 citation statements)

References 17 publications

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“…Herein, we report a suppression of chaperoning/stress response proteins in the adult hippocampus at age 6 months from identically exposed animals that was coupled to an increase in one form of superoxide dismutase and an impact on the NRF2 mediated oxidative stress response pathway. Similar findings of sustained oxidative stress were noted in offspring experiencing restraint stress during pregnancy [82], [83, 84], prenatal hypoxia [85, 86], heavy metal exposure [87, 88], and malnutrition [89–91]. Though a trend toward impaired GSH/GSSG ratio and antioxidant enzyme activities within the hippocampus of adult offspring with prior CSE was evident, the cerebral cortex of offspring with prior CSE did exhibit a loss of total glutathione.…”

Section: Discussionsupporting

confidence: 71%

Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring

Neal

Jagadapillai

Chen

et al. 2016

Reproductive Toxicology

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Exposure to cigarette smoke during development is linked to neurodevelopmental delays and cognitive impairment including impulsivity, attention deficit disorder, and lower IQ. Utilizing a murine experimental model of "active" inhalation exposure to cigarette smoke spanning the entirety of gestation and through human third trimester equivalent hippocampal development [gestation day 1 (GD1) through postnatal day 21 (PD21)], we examined hippocampus proteome and metabolome alterations present at a time during which developmental cigarette smoke exposure (CSE)-induced behavioral and cognitive impairments are evident in adult animals from this model system. At six month of age, carbohydrate metabolism and lipid content in the hippocampus of adult offspring remained impacted by prior exposure to cigarette smoke during the critical period of hippocampal ontogenesis indicating limited glycolysis. These findings indicate developmental CSE-induced systemic glucose availability may limit both organism growth and developmental trajectory, including the capacity for learning and memory.

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Section: Discussionsupporting

confidence: 71%

Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring

Neal

Jagadapillai

Chen

et al. 2016

Reproductive Toxicology

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“…It has previously been shown that oxidative damage produced by prenatal restrain stress resulted in neuronal loss in rat offspring [22C]. Exposure to early as well as late gestational stress brought about brain oxidative damage where decline in SOD, GSH and GSSG-Rd activities [23,39], increase in lipid peroxidation and decrease in total antioxidant capacity were observed [22]. An increase in the content of reactive oxygen species in the hippocampus of prenatally stressed rat offspring was reported by Li et al [20].…”

Section: Discussionmentioning

confidence: 99%

Status of the brain antioxidant system at different growing periods after prenatal stress and N -acetyl cysteine administration

Bernhardt¹,

Madhyastha²,

Bairy³

et al. 2017

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“…20 Coping styles have been conceptualized in terms of specific stressful situations people experience and the different mechanisms they use to adapt and buffer its effects. 21 These can involve problem, emotion or avoidance-based strategies to reduce stressful situations. 22 Problem-or task-focused coping involves facing the challenges and seeking solutions to the stressful situation.…”

Section: Introductionmentioning

confidence: 99%

The relationship between levels of resilience and coping styles in chiropractic students and perceived levels of stress and well-being

Innes¹

2017

Journal of Chiropractic Education

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Objective The aim of this study was to explore the relationship between chiropractic students' coping styles and levels of resilience with their physical injuries, perceived levels of stress, and well-being. Methods A questionnaire was distributed to the entire student body of the chiropractic program at Murdoch University, and gathered demographic variables and responses to the Connor-Davidson Resilience Scale, Perceived Levels of Stress Scale, Everyday Feelings Questionnaire, and Coping Inventory for Stressful Situations. Linear regression analysis was used to calculate for significant relationships. Results Of 244 students, 194 (81%) completed the surveys. Being female and not having recovered from an injury within 12 months was significantly associated with lower levels of well-being and higher levels of stress. Being female, possessing an increased use of an emotional-based coping style, and having lower levels of well-being were associated with higher levels of stress (R2 = 0.65, F(6,164) = 50.47, p < .001). Lower levels of well-being were associated with being female, higher perceived levels of stress, lower levels of resilience, and an increased use emotional coping styles (R2 = 0.64, F[6,164] = 49.5, p < .001). Conclusion It is possible to identify chiropractic students at the university who are at risk of experiencing low levels of well-being and high levels of stress. These students may benefit from interventions aimed at enhancing their coping style choices and increasing their resilience levels. Future studies are recommended to see if these findings are consistent across chiropractic programs nationally and internationally.

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Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons

Abstract: These results show the neuroprotective abilities of resveratrol against prenatal-stress-induced oxidative damage in neonatal rat brain.

Cited by 18 publications

References 17 publications

Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring

Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring

Status of the brain antioxidant system at different growing periods after prenatal stress and N -acetyl cysteine administration

The relationship between levels of resilience and coping styles in chiropractic students and perceived levels of stress and well-being

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