2018
DOI: 10.1186/s41927-018-0036-5
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Resveratrol displays anti-inflammatory properties in an ex vivo model of immune mediated inflammatory arthritis

Abstract: Background Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune cells and connective tissues, but only few studies have investigated effects on immune mediated inflammatory arthritis. None of which have studied this effect when combining resveratrol with methotrexate or adalimumab, two major drugs in the treatment of immune mediated inflammatory… Show more

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Cited by 21 publications
(10 citation statements)
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“…It has been shown that RES possesses numerous therapeutic effects, such as antioxidant [68][69][70][71], anti-inflammatory [72][73][74][75], cardioprotective [76][77][78][79], or analgesic effects [80][81][82], and has an impact on diabetes and obesity [83][84][85]. RES has been further studied for its increasing relevance in various neurological disorders, such as Alzheimer's [86][87][88], Parkinson's [89,90], and other neurodegenerative diseases [91,92], as well as brain tumors [93][94][95].…”
Section: Biological Effects Of Resveratrolmentioning
confidence: 99%
“…It has been shown that RES possesses numerous therapeutic effects, such as antioxidant [68][69][70][71], anti-inflammatory [72][73][74][75], cardioprotective [76][77][78][79], or analgesic effects [80][81][82], and has an impact on diabetes and obesity [83][84][85]. RES has been further studied for its increasing relevance in various neurological disorders, such as Alzheimer's [86][87][88], Parkinson's [89,90], and other neurodegenerative diseases [91,92], as well as brain tumors [93][94][95].…”
Section: Biological Effects Of Resveratrolmentioning
confidence: 99%
“…Previous studies have indicated the beneficial effects of sirtuins as the best small molecule that activate sirtuins, which extended lifespan in a yeast model [104][105][106][107][108][109]. Although only the longevity extension effect of resveratrol has been reported in C. elegans and D. melanogaster, many subsequent studies reported that resveratrol intake promotes health and plays a preventive role in age-related diseases, such as cancer [110][111][112][113], atherosclerosis [114,115], arthritis [116,117], cataract [118][119][120], cardiovascular disease [121], hypertension [122,123], type 2 diabetes [124][125][126][127], osteoporosis [128][129][130], and Alzheimer disease [131][132][133]. In clinical studies, resveratrol intake improved the memory capacity of elderly individuals and reduced blood lipid levels in obese and type 2 diabetic patients [134,135].…”
Section: Resveratrolmentioning
confidence: 99%
“…In this systematic review, we focused on the aberrant expression of miRs, DNA methylation and histone modifications on RA. However, it is important to note that phytopharmaceuticals natural products such as curcumin [90] and resveratrol [91,92], nutrition and environmental conditions can influence chronic diseases such as RA.…”
Section: Discussionmentioning
confidence: 99%