Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators

Li, Chang; Xu, Xiaofei; Tao, Zhihao; Wang, Xiu Jun; Pan, Yuanjiang

doi:10.1016/j.foodchem.2014.09.165

Cited by 42 publications

(29 citation statements)

References 38 publications

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“…We identified four stilbenes ( Figure 1) in the culture medium of V. labrusca cells by LC-MS analysis: Trans-resveratrol ([M−H] + 229, fragmented ion 135) and its dimers, pallidol ([M−H] + 455, fragmented ion 361), δ-viniferin ([M−H] + 455, fragment ions 437, 361) and the dimer ε-viniferin that was identified by comparison with pure standard. Pallidol is a bio-active compound and was recently demonstrated to regulate angiogenesis [38] and cancer-related signaling pathways [39]. These results are supported by a previous reported phytochemical study on V. labrusca cell suspension [4].…”

Section: Optimization Of Meja Elicitation In Flask Experimentssupporting

confidence: 74%

Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Lambert

Lemaire

Auger

et al. 2019

Plants

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Resveratrol and its oligomers are biologically active compounds. This work brings new insights for the bioproduction of trans-resveratrol with three dimers, pallidol, trans-ε-viniferin, and trans-δ-viniferin, in cell suspension of Vitis labrusca. Conditions of elicitation by methyl jasmonate were optimized for the production of stilbenes using statistical design of experiment. Bio-production of stilbenes was scaled-up to 5 L and in these conditions, trans-resveratrol concentrations reached 237 mg/L, and for pallidol 114 mg/L. The comparison of different elicitation modes (different elicitors, combination with cyclodextrins or adsorbent resin) allowed to reach particularly high concentrations of target molecules: Resveratrol 6.14 g/L, pallidol 0.90 g/L, δ-viniferin 0.54 g/L, and ε-viniferin 0.50 g/L. Scale-up to 20 L-stirring-bioreactor gave similar growth rates to those observed in shake flask culture, with a high production of resveratrol (4.23 g/L) and δ-viniferin (0.76 g/L). This work provides new strategies for the production of stilbenes in plant cell suspension for biological and commercial evaluation.

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Section: Optimization Of Meja Elicitation In Flask Experimentssupporting

confidence: 74%

Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Lambert

Lemaire

Auger

et al. 2019

Plants

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“…DPPH radical scavenging activities were evaluated as we have described previously by the use of a microplate [28,29]. In brief, the reaction mixture containing 180 µL DPPH (150 µM freshly made methanol solution) and 20 µL sample/blank solution in methanol was taken in a 96-well microplate and incubated at 37 • C for 30 min.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

Green and Efficient Ultrasonic-Assisted Extraction of Bioactive Components from Salvia miltiorrhiza by Natural Deep Eutectic Solvents

He¹,

Yang²,

Huang³

et al. 2019

Molecules

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Natural deep eutectic solvents (NaDESs) are recently developed green solvent alternatives to conventional fossil solvents. The present work systematically screened 22 different NaDESs for the ultrasonic-assisted extraction of bioactive components from Salvia miltiorrhiza (SM), a widely used traditional Chinese medical plant. The suitable solvent and extraction condition were optimized in a two-round screening. In comparison with fossil solvents, NaDESs, especially L-proline-lactic acid (L-Pro-Lac) showed significant advantages in the extraction of salvianolic acid B (SAB), tanshinone IIA (TIIA) and cryptotanshinone (CYT). The optimized yields of the three targeting compounds were 42.05, 1.485 and 0.839 mg/g, respectively. The present method was also applied to the pretreatment of SM samples from different geographic origins. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities of NaDES extracts were determined in the study to prove the feasibility of NaDES in bioactive component extraction. The application of NaDESs in the extraction of both hydrophilic and hydrophobic small molecules from SM is proved to be a green and efficient method for pretreatment of herbal materials.

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“…Recently, a study by Li and colleagues provided further evidence supporting the role of RES in Nrf2/ARE activation. In this study, exposure of the dimerized form, but not any other form, of RES (30 mM) directly increased Nrf2 transcriptional activities in vitro (Li et al, 2015a). Taken together, these results suggest that RES activates Nrf/ARE in a structurally specific mechanism, possibly binding directly to Nrf2 or Keap-1; however, the exact mechanism is not yet defined.…”

Section: Effects Of Pterostilbene and Resveratrol During Cellular Strmentioning

confidence: 48%

Effects of pterostilbene and resveratrol on brain and behavior

Poulose

Thangthaeng

Miller

et al. 2015

Neurochemistry International

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Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators

Cited by 42 publications

References 38 publications

Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

Green and Efficient Ultrasonic-Assisted Extraction of Bioactive Components from Salvia miltiorrhiza by Natural Deep Eutectic Solvents

Effects of pterostilbene and resveratrol on brain and behavior

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