Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells

Zhang, Yun; Guo, Linlin; Law, Betty Yuen‐Kwan; Liang, Xiaofeng; Ma, Ning; Xu, Guofeng; Wang, Xiaoyun; Yuan, Xiefang; Tang, Hongmei; Chen, Qi; Wong, Vincent Kam‐Wai; Wang, Xing

doi:10.3892/ijmm.2020.4539

Cited by 13 publications

(7 citation statements)

References 46 publications

(50 reference statements)

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“…Previous reports suggest RSV contributes to the maintenance of genomic stability through direct and indirect associations with target proteins [ 39 ]. For example, RSV inhibits oxidative DNA damage by reducing ROS levels in bronchial epithelial cells [ 40 ]. In 293T cells, RSV directly binds to the active site of TyrRS and stimulates the activation of PARP1, which promotes BRCA1-mediated homologous recombination repair [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

et al. 2023

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Cutaneous radiation injury (CRI) interrupts the scheduled process of radiotherapy and even compromises the life quality of patients. However, the current clinical options for alleviating CRI are relatively limited. Resveratrol (RSV) has been shown to be a promising protective agent against CRI; yet the mechanisms of RSV enhancing radioresistance were not fully elucidated and limited its clinical application. In this study, we demonstrate RSV promotes cutaneous radioresistance mainly through SIRT7. During ionizing radiation (IR) treatment, RSV indirectly phosphorylates and activates SIRT7 through AMPK, which is critical for maintaining the genome stability of keratinocytes. Immunoprecipitation and mass spectrometry identified HMGB1 to be the key interacting partner of SIRT7 to mediate the radioprotective function of RSV. Mechanistic study elucidated that SIRT7 interacts with and deacetylates HMGB1 to redistribute it into nucleus and “switch on” its function for DNA damage repair. Our findings establish a novel AMPK/SIRT7/HMGB1 regulatory axis that mediates the radioprotective function of RSV to alleviate IR-induced cutaneous DNA injury, providing an efficiently-curative option for patients with CRI during radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

et al. 2023

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“…These data suggest that RES has a wide range of anticancer effects, but on the contrary, accumulating studies have also showed that RES has a profound anti-apoptosis effect. Zhang et al demonstrated that RES increases the expression of SIRT1 and boosts antioxidant capacity, thereby reducing mitochondrial-associated apoptosis signaling pathways and preventing ROS-induced myoblast damage [ 63 ]. The controversial role of RES in the proliferation and apoptosis of endothelial cells may depend on the dose of RES.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis

Zhao

et al. 2022

Nutrients

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Atherosclerosis is a chronic inflammatory vascular disease in which endothelial cells play an important role in maintaining vascular homeostasis. Endotheliitis caused by endothelial dysfunction (ED) is the key cause for the development of cardiovascular and cerebrovascular diseases as well as other vascular system diseases. Resveratrol (RES), a multi-functional polyphenol present in edible plants and fruits, prevents cardiovascular disease by regulating a variety of athero-relevant signaling pathways. By transcriptome profiling of RES-treated human umbilical vein endothelial cells (HUVECs) and in-depth bioinformatic analysis, we observed that differentially expressed genes (DEGs) were enriched in KEGG pathways of fluid shear stress and atherosclerosis, suggesting that the RES may serve as a good template for a shear stress mimetic drug that hold promise in combating atherosclerosis. A heat map and multiple datasets superimposed screening revealed that RES significantly down-regulated phosphatase and actin modulator 1 (PHACTR1), a pivotal coronary artery disease risk gene associated with endothelial inflammation and polyvascular diseases. We further demonstrate that RES down-regulated the gene and protein expression of PHACTR1 and inhibited TNF-α-induced adhesion of THP-1 monocytes to activated endothelial cells via suppressing the expression of PHACTR1. Taken together, our study reveals that PHACTR1 represents a new molecular target for RES to maintain endothelial cell homeostasis and prevent atherosclerotic cardiovascular disease.

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“…Resveratrol also reduces caspase-3, an indicator of apoptosis [109]. In basic experiments using a mouse model of HDM-induced asthma, resveratrol reduced cell apoptosis and suppressed the expression of the γH2AX gene, which is associated with DNA damage [110]. Activation of SIRT1 suppresses epithelial damage, which may inhibit apoptosis and control viral-induced asthma exacerbations.…”

Section: The Relationship Between Sirt1 and Ilc2 In Virus-induced Astmentioning

confidence: 99%

Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach

Fukuda

Akimoto

Homma

et al. 2020

JCM

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The prevalence of asthma has increased worldwide. Asthma exacerbations triggered by upper respiratory tract viral infections remain a major clinical problem and account for hospital admissions and time lost from work. Virus-induced asthma exacerbations cause airway inflammation, resulting in worsening asthma and deterioration in the patients’ quality of life, which may require systemic corticosteroid therapy. Despite recent advances in understanding the cellular and molecular mechanisms underlying asthma exacerbations, current therapeutic modalities are inadequate for complete prevention and treatment of these episodes. The pathological role of cellular senescence, especially that involving the silent information regulator 2 homolog sirtuin (SIRT) protein family, has recently been demonstrated in stable and exacerbated chronic respiratory disease states. This review discusses the role of SIRT1 in the pathogenesis of bronchial asthma. It also discusses the role of SIRT1 in inflammatory cells that play an important role in virus-induced asthma exacerbations. Recent studies have hypothesized that SIRT1 is one of major contributors to cellular senescence. SIRT1 levels decrease in Th2 and non-Th2-related airway inflammation, indicating the role of SIRT1 in several endotypes and phenotypes of asthma. Moreover, several models have demonstrated relationships between viral infection and SIRT1. Therefore, targeting SIRT1 is a novel strategy that may be effective for treating virus-induced asthma exacerbations in the future.

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Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells

Cited by 13 publications

References 46 publications

Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis

Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach

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