Resveratrol’ biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Sharifi‐Rad, Javad; Quispe, Cristina; Durazzo, Alessandra; Lucarini, Massimo; Souto, Eliana B.; Santini, Antonello; Imran, Muhammad; Moussa, Ashaimaa Y.; Mostafa, Nada M.; El‐Shazly, Mohamed; Batiha, Gaber El‐Saber; Qusti, Safaa; Alshammari, Eida M.; Şener, Bilge; Schoebitz, Mauricio; Martorell, Miquel; Alshehri, Mohammed M.; Dey, Abhijit; Cruz‐Martins, Natália

doi:10.1016/j.hermed.2022.100550

Cited by 57 publications

(31 citation statements)

References 158 publications

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“…Resveratrol is a controversial natural chemical with anti-tumour properties that is being investigated as a possible treatment possibility [ 92 ]. Resveratrol can preferentially trigger autophagy and apoptosis in the T-cell acute lymphoblastic leukaemia cells via suppression of mTOR/AKT/4E-BP1/p70S6K and initiation of p38-MAPK pathways [ 93 ].…”

Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

“…Although natural products show excellent results in vitro, the development of cytostatic drugs in them is a complex process, except for a few. The therapeutic advantage of these natural products is their minimal toxicity and reduced side effects [ 92 , 128 , 129 ]. But natural bioactive compounds can interact with many proteins, which is why it is very important to elucidate the mechanisms of action of natural products, especially those that are used in our diet [ 130 ].…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

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Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are altered in a variety of diseases, including cancer. Extant studies on the homeostatic and pathologic behavior of MAPK signaling have been conducted; however, much remains to be explored in preclinical and clinical research in terms of regulation and action models. MAPK has implications for cancer therapy response, more specifically in response to experimental MAPK suppression, compensatory mechanisms are activated. The current study investigates MAPK as a very complex cell signaling pathway that plays roles in cancer treatment response, cellular normal conduit maintenance, and compensatory pathway activation. Most MAPK inhibitors, unfortunately, cause resistance by activating compensatory feedback loops in tumor cells and tumor microenvironment components. As a result, innovative combinatorial treatments for cancer management must be applied to limit the likelihood of alternate pathway initiation as a possibility for generating novel therapeutics based on incorporation in translational research. We summarize current knowledge about the implications of ERK (MAPK) in cancer, as well as bioactive products from plants, microbial organisms or marine organisms, as well as the correlation with their chemical structures, which modulate this pathway for the treatment of different types of cancer.

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Section: Ras-erk and Natural Bioactive Compounds In Chemotherapy And ...mentioning

confidence: 99%

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali

Akter

Ramproshad³

et al. 2022

Cancer Cell Int

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“…The oxidative stress caused by the reactive oxygen stress leads to various ailments such as neurological disorders, cardiovascular diseases, and cancer [ 58 – 60 ]. Health benefits of diosgenin administration are most commonly determined as a neuroprotective agent in terms of cognitive effects [ 61 – 63 ], neuroinflammation [ 51 , 64 – 67 ], multiple sclerosis [ 68 , 69 ], spinal cord injury [ 70 , 71 ], stroke and thrombosis [ 72 ], and neuropathic pain [ 43 , 73 – 75 ].…”

Section: Pharmacological Properties Of Diosgenin: Underlying Molecula...mentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.

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“…Oxidative stress is triggered by an imbalance between the amount of reactive oxygen species/free radicals, which cause harmful effects, and the body’s natural antioxidant defense mechanisms [ 125 , 126 ]. In recent decades, research has focused on finding natural antioxidant substances that can neutralize the negative potential of free radicals [ 127 , 128 , 129 ]. Previous studies have demonstrated the antioxidant and radical scavenging activity of the fruit (flesh), kernel, oil, pomace, bark, and leaf extracts in vitro [ 73 , 102 , 130 ].…”

Section: Other Pharmacological Propertiesmentioning

confidence: 99%

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

Kitić

Miladinović

Randjelović

et al. 2022

Plants

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Prunus armeniaca L. (Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The plant is thought to originate from the northern, north-western, and north-eastern provinces of China, although some data show that it may also come from Korea or Japan. The apricot fruit is used medicinally to treat a variety of ailments, including use as an antipyretic, antiseptic, anti-inflammatory, emetic, and ophthalmic remedy. The Chinese and Korean pharmacopeias describe the apricot seed as an herbal medicinal product. Various parts of the apricot plant are used worldwide for their anticancer properties, either as a primary remedy in traditional medicine or as a complementary or alternative medicine. The purpose of this review was to provide comprehensive and up-to-date information on ethnobotanical data, bioactive phytochemicals, anticancer potential, pharmacological applications, and toxicology of the genus Prunus armeniaca, thus providing new perspectives on future research directions. Included data were obtained from online databases such as PubMed/Medline, Google Scholar, Science direct, and Wiley Online Library. Multiple anticancer mechanisms have been identified in in vitro and in vivo studies, the most important mechanisms being apoptosis, antiproliferation, and cytotoxicity. The anticancer properties are probably mediated by the contained bioactive compounds, which can activate various anticancer mechanisms and signaling pathways such as tumor suppressor proteins that reduce the proliferation of tumor cells. Other pharmacological properties resulting from the analysis of experimental studies include neuroprotective, cardioprotective, antioxidant, immunostimulatory, antihyperlipidemic, antibacterial, and antifungal effects. In addition, data were provided on the toxicity of amygdalin, a compound found in apricot kernel seeds, which limits the long-term use of complementary/alternative products derived from P. armeniaca. This updated review showed that bioactive compounds derived from P. armeniaca are promising compounds for future research due to their important pharmacological properties, especially anticancer. A detailed analysis of the chemical structure of these compounds and their cytotoxicity should be carried out in future research. In addition, translational pharmacological studies are required for the correct determination of pharmacologically active doses in humans.

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Resveratrol’ biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Cited by 57 publications

References 158 publications

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

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