Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Corrêa, Mônica Grazieli; Absy, Samir; Tenenbaum, Howard; Ribeiro, Fernanda Vieira; Cirano, Fabiano Ribeiro; Casati, Márcio Zaffalon; Pimentel, Suzana Peres

doi:10.1111/jre.12622

Cited by 39 publications

(42 citation statements)

References 83 publications

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“…Indeed, the detailed effects of calcitriol on Th cell polarization remain largely unknown. In the future, other anti‐inflammatory and antioxidant modulators such as resveratrol may be used in combination with calcitriol to prevent periodontal tissue destruction for periodontitis prevention or treatment …”

Section: Discussionmentioning

confidence: 99%

“…In the future, other anti-inflammatory and antioxidant modulators such as resveratrol may be used in combination with calcitriol to prevent periodontal tissue destruction for periodontitis prevention or treatment. 67 Calcitriol has been shown to play a pivotal role in the decrease in periodontal inflammation during the progression of periodontitis, and hence, can ameliorate experimental periodontitis in diabetic mice. 68 After calcitriol treatment in a mouse model of diabetes mellitus, Tcell protein tyrosine phosphatase non-receptor type 2 (PTPN2), an intracellular tyrosine-specific phosphatase, was shown to inhibit inflammation in diabetes mellitus-associated periodontitis via dephosphorylation of protein substrates in the JAK1/STAT3 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

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Calcitriol suppresses lipopolysaccharide‐induced alveolar bone damage in rats by regulating T helper cell subset polarization

Wang

et al. 2019

J of Periodontal Research

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Background Although the immunomodulatory properties of calcitriol in bone metabolism have been documented for decades, its therapeutic role in the management of periodontitis remains largely unexplored. In this study, we hypothesized that calcitriol suppresses lipopolysaccharide (LPS)‐induced alveolar bone loss by regulating T helper (Th) cell subset polarization. Methods To test this hypothesis, we determined the effect of calcitriol intervention on the development of LPS‐induced periodontitis in rats in terms of bone loss (micro‐CT analysis), local inflammatory infiltration levels, the number of osteoclasts (hematoxylin and eosin staining) and the level of osteoclastogenesis (tartrate‐resistant acid phosphatase method). Furthermore, immunohistochemistry was used to assess the expression levels of the receptor activator of NF‐κB ligand (RANKL) and osteoprotegerin (OPG) as well as the cytokine levels of interferon‐γ (IFN‐γ), interleukin‐4 (IL‐4), IL‐17, and IL‐10 throughout the LPS‐injected region. Finally, the polarization potential of Th cells in peripheral blood was analyzed using flow cytometry. Results Calcitriol intervention decreased alveolar bone loss in response to LPS injection and inflammatory cell infiltration. Analysis of osteoclast number and RANKL and OPG expression showed that bone resorption activity was largely suppressed in response to calcitriol administration, along with decreased IL‐17 levels but increased IL‐4 and IL‐10 levels in periodontal tissues (the LPS‐injected region). Similarly, the percentages of Th2 and Treg cells in peripheral blood increased, but the percentages of Th1 and Th17 cells decreased in rats receiving calcitriol. Conclusion Our findings suggest that calcitriol can be used to inhibit bone loss in experimental periodontitis, likely via the regulation of local and systemic Th cell polarization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calcitriol suppresses lipopolysaccharide‐induced alveolar bone damage in rats by regulating T helper cell subset polarization

Wang

et al. 2019

J of Periodontal Research

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“…1,10 It is also known that cigarette-smoking delays wound healing by inducing a state of oxidative stress in tissues and enhancing the production of proinflammatory and toxic endproducts in oral and systemic tissues. 11,12 These explanations have been associated with compromised outcomes of surgical and nonsurgical oral therapeutic interventions in individuals smoking tobacco-products compared with never-smokers. 13,14 However, outcome of MD with and without adjunct PT in the treatment of PiM among cigarette-smokers and never-smokers remains unreported in literature.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of mechanical debridement with adjunctive probiotic therapy in the treatment of peri‐implant mucositis in cigarette‐smokers and never‐smokers

Alqahtani

Shafqat

et al. 2019

Clin Implant Dent Rel Res

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Background: Efficacy of mechanical debridement (MD) with adjunctive probiotic therapy (PT) in the treatment of peri-implant mucositis (PiM) in cigarette-smoking and never-smoking subjects remains uninvestigated.Purpose: The aim was to assess the efficacy of MD with adjunctive PT in the treatment of PiM in cigarette-smoking and never-smoking individuals.Materials and Methods: Patients with (group I) and without PiM (group II) were included. Demographic data was collected using a questionnaire. Treatment-wise, patients in groups I and II were subdivided into: (a) Patients that underwent MD with adjunct PT (using Lactobacillus reuteri); and (b) MD alone. In all groups, probing depth (PD), plaque index (PI), and bleeding on probing (BOP) were measured at baseline and compared after 3-and 6-months. Baseline peri-implant crestal bone levels were also measured. Sample-size estimation was performed, and statistical comparisons were done using one-way analysis of variance and Bonferroni post-hoc adjustment tests.P values under .05 were deemed significant.Results: Eighty individuals (group I: 40 cigarette-smokers and group II: 40 neversmokers) with PiM participated in this study. At all-time intervals, no significant difference in PD, PI, and BOP were observed in all patients in group I. At 3-months' follow-up, the differences in BOP (P < .05), and PI (P < .05) were significantly higher in group II that underwent MD + PT than MD alone. At 6-months' follow-up, there was no difference in the changes in BOP and PI among subjects that underwent MD with and without adjunct PT.Conclusion: On a short-term basis, MD with adjunct PT is more effectual in the treatment of PiM than MD alone in never-smokers. Cigarette-smoking compromises periimplant soft tissue healing following MD with or without adjunct PT. K E Y W O R D Sbleeding on probing, cigarette smoking, dental implant, inflammation, Lactobacillus reuteri, probiotics

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“…Furthermore, outcomes of oral surgical interventions are undermined in tobacco smoking users compared to nonsmokers . Tobacco smoking creates an oxidative state of stress in the gingival tissues; and chemicals such as carbon monoxide and nicotine increase the production of advanced‐glycation‐end products and it's deposition in oral tissues . Binding of AGEs along to their receptors worsens periodontal inflammation .…”

Section: Introductionmentioning

confidence: 99%

Soft tissue status and crestal bone loss around conventionally‐loaded dental implants placed in cigarette‐ and waterpipe (narghile) smokers: 8‐years' follow‐up results

AlAhmari

Javed

Ahmed³

et al. 2019

Clin Implant Dent Rel Res

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Background We hypothesized that crestal bone loss (CBL) and peri‐implant soft tissue inflammation are increased when conventionally‐loaded dental implants are placed in cigarette and waterpipe smokers compared to nonsmokers. Purpose The present 8‐years' follow‐up retrospective clinical study evaluated the stability of the conventionally‐loaded dental implants placed in cigarette‐ and waterpipe (narghile) smoking and nonsmoking population group. Materials and Methods Self‐reported cigarette‐smokers, waterpipe users along with never‐smokers have been included. Data pertaining to gender, age, duration and frequency of cigarette‐smoking, and usage of waterpipe were collected using a preformed questionnaire. Probing depth (PD), bleeding on probing (BOP), and peri‐implant plaque index (PI) were recorded measuring mesial and distal CBL on digital bitewing radiographs. Study power estimated with group comparisons performed using the Kruskal‐Wallis and Bonferroni post‐hoc adjustment tests. Statistically significant P‐values of less than 0.05 were considered. Results Forty‐one cigarette‐smokers, forty waterpipe‐users, and forty‐two never‐smokers with mean ages of 44.5 ± 4.3, 41.2 ± 4.7, 43.3 ± 2.8 years, respectively, were included. The mean duration of smoking habit and duration of each session of cigarette‐smoking was 5.5 ± 0.3 years and 7.7 ± 1.2 minutes, respectively. The mean period of waterpipe use and time of each session of was 10.6 ± 0.8 years and 20.2 ± 3.1 minutes, respectively. Among cigarette‐smokers, waterpipe‐users and never‐smokers, the implants had been in function for 8.5 ± 0.3, 8.6 ± 0.3, and 8.5 ± 0.5 years, respectively. PD, CBL, and peri‐implant PI were positively more among cigarette and waterpipe smoking users (P < 0.05) than with never‐smokers. Peri‐implant bleeding on probing was significant among never‐smokers (P < 0.05) compared to waterpipe‐users and cigarette‐smokers. There was no difference in Peri‐implant PI, PD, and CBL in cigarette‐smokers and waterpipe‐users. Conclusions Cigarette‐smokers and waterpipe users are vulnerable to peri‐implant soft tissue inflammation and CBL than never‐smokers. There is no variation in the severity of peri‐implant soft tissue inflammation and CBL in waterpipe and cigarette users.

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Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation

Cited by 39 publications

References 83 publications

Calcitriol suppresses lipopolysaccharide‐induced alveolar bone damage in rats by regulating T helper cell subset polarization

Calcitriol suppresses lipopolysaccharide‐induced alveolar bone damage in rats by regulating T helper cell subset polarization

Efficacy of mechanical debridement with adjunctive probiotic therapy in the treatment of peri‐implant mucositis in cigarette‐smokers and never‐smokers

Soft tissue status and crestal bone loss around conventionally‐loaded dental implants placed in cigarette‐ and waterpipe (narghile) smokers: 8‐years' follow‐up results

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