Resveratrol attenuates lipopolysaccharide-induced hepatitis in d-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1

Farghali, Hassan; Černý, Dalibor; Kameníková, L; Martínek, J; Hořínek, Aleš; Kmoníčková, Eva; Zı́dek, Zdeňek

doi:10.1016/j.niox.2009.09.004

Cited by 62 publications

(38 citation statements)

References 53 publications

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“…Resveratrol injection in the presence of LPS caused a selective up-regulation of PGC-1a, in association with the preservation of hepatic mitochondrial biogenesis. These results are in agreement with previous studies which have shown that resveratrol can protect against LPS-induced hepatitis in part through upregulation of HO-1 and downregulation of iNOS (13).…”

Section: Discussionsupporting

confidence: 94%

Resveratrol Induces Hepatic Mitochondrial Biogenesis Through the Sequential Activation of Nitric Oxide and Carbon Monoxide Production

Kim

Joe²,

Zheng³

et al. 2014

Antioxidants & Redox Signaling

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Aims: Nitric oxide (NO) can induce mitochondrial biogenesis in cultured cells, through increased guanosine 3¢,5¢-monophosphate (cGMP), and activation of peroxisome proliferator-activated receptor gamma coactivator1a (PGC-1a). We sought to determine the role of NO, heme oxygenase-1 (HO-1), and its reaction product (carbon monoxide [CO]) in the induction of mitochondrial biogenesis by the natural antioxidant resveratrol. Results: Snitroso-N-acetylpenicillamine (SNAP), an NO donor, induced mitochondrial biogenesis in HepG2 hepatoma cells, and in vivo, through stimulation of PGC-1a. NO-induced mitochondrial biogenesis required cGMP, and was mimicked by the cGMP analogue (8-bromoguanosine 3¢,5¢-cyclic monophosphate [8-Br-cGMP]). Activation of mitochondrial biogenesis by SNAP required HO-1, as it could be reversed by genetic interference of HO-1; and by treatment with the HO inhibitor tin-protoporphyrin-IX (SnPP) in vitro and in vivo. Cobalt protoporphyrin (CoPP)-IX, an HO-1 inducing agent, stimulated mitochondrial biogenesis in HepG2 cells, which could be reversed by the CO scavenger hemoglobin. Application of CO, using the CO-releasing molecule-3 (CORM-3), stimulated mitochondrial biogenesis in HepG2 cells, in a cGMP-dependent manner. Both CoPP and CORM-3-induced mitochondrial biogenesis required NF-E2-related factor-2 (Nrf2) activation and phosphorylation of Akt. The natural antioxidant resveratrol induced mitochondrial biogenesis in HepG2 cells, in a manner dependent on NO biosynthesis, cGMP synthesis, Nrf2-dependent HO-1 activation, and endogenous CO production. Furthermore, resveratrol preserved mitochondrial biogenesis during lipopolysaccharides-induced hepatic inflammation in vivo. Innovation and Conclusions: The complex interplay between endogenous NO and CO production may underlie the mechanism by which natural antioxidants induce mitochondrial biogenesis.

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Section: Discussionsupporting

confidence: 94%

Resveratrol Induces Hepatic Mitochondrial Biogenesis Through the Sequential Activation of Nitric Oxide and Carbon Monoxide Production

Kim

Joe²,

Zheng³

et al. 2014

Antioxidants & Redox Signaling

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“…This removal of cellular debris is vital for the regeneration of lost tissue. Typical examples are CCl 4 -induced hepatic injury, concanavalin-A [27], lipopolysaccharide [8] or acetaminophen hepatotoxicity, which trigger the inflammatory response, with neutrophils appearing within an hour after early liver injury and the recruitment of monocytes and macrophages after 24-48 h [6,16]. In our in-vivo experiments, the crude extract and its fractions, as well as the isolated steroidal alkaloids, showed excellent protective results by suppressing the damage to the hepatocytes without causing any side effects on other tissues.…”

Section: Discussionmentioning

confidence: 99%

Immunosuppressive and hepatoprotective potential of Sarcococca saligna and its biomarker components

Ali

Musharraf

Iqbal

et al. 2015

International Immunopharmacology

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“…Silymarin and resveratrol are two of many examples of natural substances that have shown a strong hepatoprotective potential due to their antioxidant, anti-inflammatory, and liver regenerative capabilities (Farghali et al, 2000a(Farghali et al, , 2009Glauert et al, 2010;Haddad et al, 2011;Pradhan & Girish, 2006).…”

Section: Scientific Rationale For the Traditional Use Of Some Plants mentioning

confidence: 99%

“…Studies on resveratrol pretreatment effects on the synergy between D-galactosamine (D-GalN) and LPS-induced liver failure in rats, and its effects on chemical prooxidants in immobilized perfused hepatocytes was investigated in our laboratory Farghali et al, 2009). Parameters studied included liver function; plasma nitrite as a measure of nitric oxide (NO); non-enzymatic and enzymatic antioxidants in plasma and liver homogenate; and morphological examinations were performed using light and electron microscopy.…”

Section: In Vitro and In Vivo Experimental Hepatotoxic Models In Livementioning

confidence: 99%

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

Farghali

Canová

Zakhari³

2014

Pharmaceutical Biology

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Context: We focused on certain plant active constituents considered to be the most promising/ studied for liver disease and that were critically investigated from the basic science point of view and, to some extent, the clinical one. Due to insufficient pharmacological data, most of the herbal formulations containing these molecules cannot be recommended for the treatment of liver disease. Objective: To present the most promising compounds tested experimentally and/or clinically and describe in brief popular models in experimental testing of potential hepatoprotective compounds. Methods: A literature search using Web of Science (WOS), PubMed, and Google search was performed.Results: Focusing on a few herbal hepatoprotective active constituents is useful to health professionals working in the field of therapeutics to develop evidence-based hepatoprotective agents by conducting research on pure chemical structures or on molecular modifications using computational chemistry. This review demonstrates that multi-pathways in the liver pathobiology can be interrupted at one or more levels by natural hepatoprotective studied, such as interference with the oxidative stress at multiple levels to reduce reactive oxygen/ nitrogen species, resulting in ameliorating hepatotoxicity. Conclusion: Hepatoprotective constituents of herbal medications are poorly absorbed after oral administration; methods that can improve their bioavailability are being developed. It is recommended that controlled prospective double-blind multicenter studies on isolated active plant constituents, or on related newly designed molecules after structural modifications, should be performed. This effort will lead to expanding the existing, limited drugs for the vast majority of liver diseases.

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Resveratrol attenuates lipopolysaccharide-induced hepatitis in d-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1

Cited by 62 publications

References 53 publications

Resveratrol Induces Hepatic Mitochondrial Biogenesis Through the Sequential Activation of Nitric Oxide and Carbon Monoxide Production

Resveratrol Induces Hepatic Mitochondrial Biogenesis Through the Sequential Activation of Nitric Oxide and Carbon Monoxide Production

Immunosuppressive and hepatoprotective potential of Sarcococca saligna and its biomarker components

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

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