Resveratrol attenuates inflammation and stricture formation in experimental caustic esophageal burns

Abstract

The purpose of medical treatment in the caustic esophageal burns (CEB) is to decrease inflammatory reaction and to prevent stricture formation. Resveratrol has anti-inflammatory and antifibrotic properties. The aim of this study is to investigate potential therapeutic effects of resveratrol in experimental CEB. We divided 42 male Wistar albino rats into five groups: a control group, caustic groups 4 and 28 (esophageal burns were created), and resveratrol groups 4 and 28 (esophageal burns were created and resveratrol was administered). We used 25% NaOH to form CEB following the method of Gehanno and Guedon as modified by Liu and Richardson. Animals were killed on the 4th and 28th days for biochemical and histopathological examinations. We found that the mean malondialdehyde and nitric oxide assays of the caustic groups were significantly higher than that of the resveratrol groups (P < 0.05). On the other hand, glutathione assay of the resveratrol groups was significantly higher than that of the caustic groups (P < 0.05). Histologically, edema, inflammation and necrosis were found to be significantly lower in the resveratrol 4 group compared with the caustic 4 group (P < 0.05). Submucosal and muscular collagen accumulation were found significantly lower in the resveratrol 28 group compared with the caustic 28 group (P < 0.05). We conclude that resveratrol decreased both the inflammatory reaction and the stricture formation in experimental CEB.

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

RETRACTED: Resveratrol rescued the TNF-α-induced impairments of osteogenesis of bone-marrow derived mesenchymal stem cells and inhibited the TNF-α-activated NF-кB signaling pathway

“…Its reliable and extensive antiinflammatory activity has attracted increasing clinical attention [11][12][13][14][15][16][17]. Previous studies demonstrated that its anti-inflammatory effect could be exploited for the treatment of esophageal burns [18], acute small intestinal inflammation [19], colitis [20,21], and many other inflammatory diseases [11,[22][23][24][25].…”

Protective Effects of Dexpanthenol and Y-27632 on Stricture Formation in a Rat Model of Caustic Esophageal Injury

“…There is no universally accepted medical treatment to avoid esophageal stricture formation [1,3,4]. Research has focused on the healing of the burned esophagus and reduction in collagen formation [9,10]. In animal experiments, a variety of different medications, such as erythropoietin, caffeic acid phenethyl ester, mitomycin C, ketotifen, and resveratrol have been used in attempt to prevent esophageal stricture formation after caustic ingestion [6][7][8][9][10].…”

“…Research has focused on the healing of the burned esophagus and reduction in collagen formation [9,10]. In animal experiments, a variety of different medications, such as erythropoietin, caffeic acid phenethyl ester, mitomycin C, ketotifen, and resveratrol have been used in attempt to prevent esophageal stricture formation after caustic ingestion [6][7][8][9][10]. We investigated the role of dexpanthenol and Y-27632, two different agents with different modes of action.…”

“…Corticosteroids, antibiotics, proton pump inhibitors, and H 2 receptor blockers are widely used in an effort to prevent stricture formation [1,4,5]. Ongoing experimental research continues to attempt to identify novel treatment strategies [6][7][8][9][10].…”