Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2

Li, Zhen; Pang, Lei; Fang, Fang; Zhang, Gongliang; Zhang, Jin; Xie, Min; Wang, Liecheng

doi:10.1016/j.brainres.2012.02.019

Cited by 90 publications

(79 citation statements)

References 47 publications

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“…As two upstream apoptosis factors, the balance between anti-apoptotic Bcl-2 and pro-apoptotic Bax is crucial in the regulation of apoptotic cell death. In our study, ischemia significantly decreased Bcl-2 expression and increased Bax expression in the MCAO rat group, which was consistent with a previous study [8]. Moreover, maternal hypoxia downregulated Bcl-2 and upregulated Bax expression in the rat offspring exposed to MCAO.…”

Section: Caspase-3 Cytochrome C Bax and Bcl-2 Expressionsupporting

confidence: 93%

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring

Wang¹,

Huang²,

Cai³

et al. 2017

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A b s t r a c t Introduction: Maternal hypoxia induces an adverse uterine environment and may induce long-term effects in offspring.This study investigated whether maternal hypoxia increases hippocampal cell vulnerability and exacerbates neurological impairments in adult rat offspring following ischemia. Material and methods: Pregnant Sprague-Dawley rats were randomly assigned to no maternal hypoxia or maternal hypoxia treatment groups. Adult male rat offspring were subjected to middle cerebral artery occlusion (MCAO). There were four groups: maternal + sham (MH + Sham), sham (Sham), maternal hypoxia + MCAO (MH + MCAO), and MCAO only (MCAO). Neurological deficits were evaluated. Hippocampal cell damage was observed by hematoxylin and eosin (HE) staining. Cell apoptosis in the hippocampus was detected by TdT-mediated dUTP-biotin nick-end labeling (TUNEL

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Section: Caspase-3 Cytochrome C Bax and Bcl-2 Expressionsupporting

confidence: 93%

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring

Wang¹,

Huang²,

Cai³

et al. 2017

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“…The antiapoptotic protein Bcl-2 is capable of preventing cytochrome c release, which is an activator of apoptosis, and promotes cell survival, while the pro-apoptotic protein (Bax) promotes cell death (19). Resveratrol has been reported to up-regulate Bcl-2 expression in a rat model of focal cerebral ischemia (15). So in the present study, we detected the expression of Bax and Bcl-2 using Western blot, and the results suggest that resveratrol increases Bcl-2 expression and decreases Bax expression, indicating that the protective effect against cerebral ischemia is related to inhibiting apoptosis.…”

Section: A B C Dmentioning

confidence: 99%

The neuroprotective effects of resveratrol preconditioning in transient global cerebral ischemia-reperfusion in mice

Liu

Sun²,

Li³

2015

Turkish Neurosurgery

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“…Among other benefits for the health, the resveratrol has anti-tumoral, anti-diabetic and anti-obesity properties (Li et al, 2012;Jeong et al, 2012). Generally, the stilbenesare recognized as biological active compounds with anti-fungal action against many pathogens (Jeandet et al, 2002).…”

Section: Stilbenes-resveratrolmentioning

confidence: 99%

“…The anti-microbial activity of resveratrol against micro-organisms that cause skin diseases, such as the bacterias Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa and the funghi Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum, was evidenced (Jeandet et al, 2002). Recently, other important biological actions of resveratrol were reported, such as the capacity to improve tolerance to glucose in diabetic patients, alleviate the symptoms of menopause and protect against osteoporosis, cancer and Alzheimer's disease (Li et al, 2012).…”

Section: Stilbenes-resveratrolmentioning

confidence: 99%

Phytochemical importance and utilization potential of grape residue from wine production

Cirqueira¹,

Costa²,

Barbosa³

et al. 2017

Afr. J. Biotechnol.

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Grapes are placed at a distinct position, both in the economy and at nutritional and phytochemical levels. The number of studies performed aimed at identifying the various bioactive compounds of grapes, how their cellular structures are linked, efficient methods of extraction and its effect on human health are rather relevant. The use of grapes for wine production is a worldwide activity, therefore a great quantity of residues are generated. These, in turn, are commonly used in soil fertilization and animal feed. Research in the food, pharmaceutical, medical and agricultural industries have revealed a great potential of using grape residue to recuperate phenolic compounds, flavonoids and especially the resveratrol. These have been found by these researches to offer benefits associated to its consumption, such as improvements in glucose tolerance in diabetic patients, decrease in the occurrence of cardiovascular diseases, diminishing the symptoms of menopause, protection against osteoporosis, cancer and Alzheimer's disease. The present work aimed at gathering information about the characterization of the phytochemical content of grapes and its residues, as well as gathering data about the extraction process of such compounds and their application in the food industry.

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Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2

Cited by 90 publications

References 47 publications

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring

Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring

The neuroprotective effects of resveratrol preconditioning in transient global cerebral ischemia-reperfusion in mice

Phytochemical importance and utilization potential of grape residue from wine production

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