Resveratrol as a therapeutic choice for traumatic brain injury: An insight into its molecular mechanism of action

Nath, Joyobrato; Roy, Rubina; Sathyamoorthy, Yogesh Kanna; Paul, Satinath; Goswami, Shweta; Chakravarty, Himabrata; Paul, Rajib; Borah, Anupom

doi:10.1016/j.dscb.2022.100038

Cited by 7 publications

(2 citation statements)

References 57 publications

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“…Specifically, curcumin may elicit these neuroprotective outcomes through upregulation of neurotrophic pathways and regulating the TLR-4, nuclear factor kappa B (NF-κB) pathways after TBI ( Zhu et al, 2014 ; Khayatan et al, 2022 ). Resveratrol is part of the polyphenol group of compounds, and a phytoalexin that is found in grapes, peanuts, and more ( Nath et al, 2022 ). Resveratrol administration after TBI has been found to reduce cognitive deficits, production of pro-inflammatory cytokines, and lesion size ( Singleton et al, 2010 ; Cong et al, 2021 ).…”

Section: Manipulating Microglia In Tbimentioning

confidence: 99%

Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

Boland,

Kokiko-Cochran

2024

Front. Cell. Neurosci.

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Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI is often associated with poor outcome. As a result, increased attention has been placed on the role of immune cells in post-injury recovery. Microglia are highly dynamic after TBI and play a key role in the post-injury neuroinflammatory response. Therefore, microglia represent a malleable post-injury target that could substantially influence long-term outcome after TBI. This review highlights the cell specific role of microglia in TBI pathophysiology. Microglia have been manipulated via genetic deletion, drug inhibition, and pharmacological depletion in various pre-clinical TBI models. Notably, colony stimulating factor 1 (CSF1) and its receptor (CSF1R) have gained much traction in recent years as a pharmacological target on microglia. CSF1R is a transmembrane tyrosine kinase receptor that is essential for microglia proliferation, differentiation, and survival. Small molecule inhibitors targeting CSF1R result in a swift and effective depletion of microglia in rodents. Moreover, discontinuation of the inhibitors is sufficient for microglia repopulation. Attention is placed on summarizing studies that incorporate CSF1R inhibition of microglia. Indeed, microglia depletion affects multiple aspects of TBI pathophysiology, including neuroinflammation, oxidative stress, and functional recovery with measurable influence on astrocytes, peripheral immune cells, and neurons. Taken together, the data highlight an important role for microglia in sustaining neuroinflammation and increasing risk of oxidative stress, which lends to neuronal damage and behavioral deficits chronically after TBI. Ultimately, the insights gained from CSF1R depletion of microglia are critical for understanding the temporospatial role that microglia develop in mediating TBI pathophysiology and recovery.

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Section: Manipulating Microglia In Tbimentioning

confidence: 99%

Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

Boland,

Kokiko-Cochran

2024

Front. Cell. Neurosci.

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“…Resveratrol attenuates kidney damage in malignant hypertension rats, and it can increase glomerular filtration while decreases proteinuria [ 398 ]. It inhibits the release of proinflammatory cytokines and leads to the release of anti-inflammatory cytokines, and it scavenges free radicals and upregulates antioxidant enzymes [ 399 ]. Chowdhury et al [ 400 ] indicated that resveratrol treatment indicated beneficial impacts on preventing oxidative stress and fibrosis in the kidneys of high-fat (HF) diet-fed rats, probably by modulating the gene expression of oxidative stress and inflammation-related parameters and enzymes.…”

Section: The Health Benefits Of Stilbenes (Resveratrol Piceatannol Pt...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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