Resveratrol as a supplemental treatment for periodontitis

Khazaei, Saber; Khazaei, Mozafar; Kazemi, Seyed Mahmood; Yaghini, Jaber

doi:10.4103/1735-3327.104891

Cited by 3 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings can be justified by the results reported by Millhouse et al, who found that resveratrol had an antimicrobial effect on planktonic bacteria and bacterial biofilms and inhibited the accumulation and activation of neutrophils [ 30 ]. Also, Khazaei et al reported resveratrol’s inhibitory effect on the expression of cell adhesion molecules; it inhibited the endothelial dysfunction caused by P. gingivalis lipopolysaccharide and blocked the expression of ICAM-1 and VCAM-1 molecules by inhibiting NF-kappa B [ 31 ]. These findings can lead to bacterial plaque rupture around the gingiva.…”

Section: Discussionmentioning

confidence: 99%

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail

2023

View full text Add to dashboard Cite

Background Periodontitis is one of the most common chronic inflammatory diseases in the world, which affects oral health. Resveratrol is a polyphenol with therapeutic effects on the inflammation caused by periodontal pathogens. This study aimed to evaluate the impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis. Methods In this randomized, double-blind study, 40 chronic periodontitis patients underwent non-surgical therapy and were randomly assigned to two intervention and control groups, receiving either resveratrol supplements or a placebo for four weeks. Salivary levels of interleukin-8 (IL-8), interleukin-1β (IL-1β), and clinical parameters, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured before and after the intervention. Results The results showed that in both the case and control groups, after four weeks of using resveratrol, only plaque index (PI) was significantly different compared to the control group (P = 0.0001). However, there were no significant differences in the mean pocket depth (PD), clinical attachment loss (CAL), bleeding index (BI), and salivary levels of IL-8 and IL-1β between the two groups after the intervention. Conclusion Resveratrol complement was helpful as an anti-inflammatory food supplement, along with other non-surgical periodontal treatments in chronic periodontitis patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail

2023

View full text Add to dashboard Cite

show abstract

“…Interest in resveratrol increased after an epidemiological study conducted in the 1970s and 1980s, known as the "French paradox". 14,15,16 Resveratrol (active substance) has the ability to prolong life, shows powerful antioxidant, antiinflammatory, cardioprotective, neuroprotective,…”

Section: Methodsmentioning

confidence: 99%

“…antitumor and antidiabetic effects. 16,17,18,19 Wine extract contains organic acids, polyphenols and minerals such as magnesium, zinc, potassium and manganese. Polyphenols contained in red wine have antioxidant and anti-inflammatory effects, prevent platelet aggregation and improve lipid metabolism.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Immunological Parameters in Patients Treated Using Direct and Indirect Restorations of the Hard Tissues of the Anterior Teeth in Combination with an Antioxidant

Kumhyr

Levko

Ozhogan

2020

IJFMT

View full text Add to dashboard Cite

The problem of aesthetic restoration of the hard tissue defects in the anterior teeth and the choice of materials for quality restorations, which can include direct composite or indirect ceramic restoration, in particular ceramic veneers, is currently extremely important in clinical dental orthopedics. Currently used composite and ceramic materials are known to have different effects on the conditions of the marginal periodontium and the local immunity in the oral cavity. Therefore, we propose a new approach to treatment, which is the use of indirect ceramic restorations in combination with an antioxidant. The purpose of this article is to increase the effectiveness of treatment in patients with defects in anterior teeth using indirect ceramic restorations with antioxidants. To study the intensity of immune reactivity in patients with existing defects of the coronal part of the anterior teeth, we analyzed the levels of lysozyme and sIgA in the oral fluid. The results of the studies confirm the advantages of indirect ceramic restorations over direct composite ones in the treatment of hard tissue defects in the anterior teeth, taking into account the levels of immunological reactivity and using an antioxidant drug Resverasin.

show abstract

“…Modern research papers have shown that the biological and pharmacological activities of resveratrol are related to its potent antioxidant properties, as well as anti-inflammatory activity and effects on lipid metabolism. In fact, the antioxidant and anti-inflammatory activity (inhibition of NF-kappa B in LPS, TNF-α), associated with antimicrobial activity (against, e.g., Streptococcus mutans , known as cariogenic oral bacteria), can play a crucial role in the treatment of periodontitis [ 5 , 6 , 7 ]. Moreover, resveratrol has also been demonstrated to inhibit platelet aggregation [ 8 ] and to have an antiestrogenic activity [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment

Paczkowska-Walendowska

Dvořák

Rosiak

et al. 2021

Pharmaceutics

View full text Add to dashboard Cite

The health benefits of resveratrol have been proven to inhibit the development of numerous diseases. A frequent limitation in its use is a low bioavailability stemming from a poor solubility and fast enterohepatic metabolism. Thus, the aim of the research was to investigate the possibility to formulate mucoadhesive cyclodextrin- and xanthan gum-based buccal tablets in order to increase the solubility of resveratrol and to eliminate bypass enterohepatic metabolism. Systems of resveratrol with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) prepared by the dry mixing method (ratio 1:1) were selected for the of tablets where xanthan gum was used as a mucoadhesive agent. They were identified on the basis of PXRD, FT-IR analysis. Tablets F1 (with α-CD), F2 (with β-CD) and F3 (with γ-CD) were characterized by the highest compactibility as well as by favorable mucoadhesive properties. Resveratrol release from these tablets was delayed and controlled by diffusion. The tablets prepared in the course of this study appear to constitute promising resveratrol delivery systems and are recommended to increase the effectiveness of the treatment in many diseases, particularly periodontitis.

show abstract

Resveratrol as a supplemental treatment for periodontitis

Cited by 3 publications

References 29 publications

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail

Changes in Immunological Parameters in Patients Treated Using Direct and Indirect Restorations of the Hard Tissues of the Anterior Teeth in Combination with an Antioxidant

Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment

Contact Info

Product

Resources

About