Resveratrol and Sir2 Reverse Sleep and Memory Defects Induced by Amyloid Precursor Protein

Hao, Yuping; Shao, Lingzhan; Hou, Jianan; Zhang, Yan; Ma, Yinfa; Liu, Jinhao; Xu, Chuan; Chen, Fujun; Cao, Li-Hui; Ping, Yong

doi:10.1007/s12264-023-01056-3

Cited by 4 publications

(1 citation statement)

References 53 publications

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“…Resveratrol (RSV), a polyphenolic nutraceutical mainly found in grapes ( Vitis vinifera L.) ( Figure 3 ), demonstrates health-promoting properties, including antioxidative [ 61 ], immunomodulatory [ 62 ], and anti-aging effects [ 63 ]. Since its association with the “French paradox” in 1992, resveratrol has received increasing research interest owing to its diverse pharmacological activities and multi-organ protective effects (e.g., acute lung injury [ 64 ], cerebral ischemia/reperfusion injury [ 65 ], myocardial cell apoptosis [ 66 ], and hepatic injury [ 67 ]).…”

Section: Resveratrol and Its Natural Derivatives—grape-derived Ace2 I...mentioning

confidence: 99%

Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Wang,

Song,

et al. 2023

Nutrients

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The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia and the industry with the aim of developing therapies and vaccines that target SARS-CoV-2. Several novel therapies have been approved and deployed in the last three years. However, their clinical application has revealed limitations due to the rapid emergence of viral variants. Therefore, the development of next-generation SARS-CoV-2 therapeutic agents with a high potency and safety profile remains a high priority for global health. Increasing awareness of the “back to nature” approach for improving human health has prompted renewed interest in natural products, especially dietary polyphenols, as an additional therapeutic strategy to treat SARS-CoV-2 patients, owing to its good safety profile, exceptional nutritional value, health-promoting benefits (including potential antiviral properties), affordability, and availability. Herein, we describe the biological properties and pleiotropic molecular mechanisms of dietary polyphenols curcumin, resveratrol, and gossypol as inhibitors against SARS-CoV-2 and its variants as observed in in vitro and in vivo studies. Based on the advantages and disadvantages of dietary polyphenols and to obtain maximal benefits, several strategies such as nanotechnology (e.g., curcumin-incorporated nanofibrous membranes with antibacterial-antiviral ability), lead optimization (e.g., a methylated analog of curcumin), combination therapies (e.g., a specific combination of plant extracts and micronutrients), and broad-spectrum activities (e.g., gossypol broadly inhibits coronaviruses) have also been emphasized as positive factors in the facilitation of anti-SARS-CoV-2 drug development to support effective long-term pandemic management and control.

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Section: Resveratrol and Its Natural Derivatives—grape-derived Ace2 I...mentioning

confidence: 99%

Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Wang,

Song,

et al. 2023

Nutrients

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Potential mechanisms of action of resveratrol in prevention and therapy for mental disorders

Menegas,

Keller,

Possamai-Della

et al. 2023

The Journal of Nutritional Biochemistry

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Grape extract and resveratrol mitigate sleep fragmentation, Aβ accumulation, and abnormal neuronal excitability in aDrosophilamodel of Alzheimer’s disease

Yu,

Xu,

Ping

2024

Preprint

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Consumption of red wine and grape extracts may offer a range of health benefits, largely attributable to the grapes’ rich content of vitamins, fiber, and antioxidant compounds, such as polyphenols. To determine if resveratrol (RES) present in grape extracts is responsible for these benefits, we conducted a study on the effects of red grape skin extract (GSKE), seed extract (GSEE), and RES on sleep patterns, amyloid-beta (Aβ) deposition, neuronal excitability, and lifespan in aDrosophilamodel expressing Aβ42. Aβ42 flies experienced significant sleep fragmentation at night, yet their overall sleep duration was unaffected. Dietary GSKE significantly enhanced sleep duration and mitigated sleep fragmentation in these flies, whereas GSEE only increased the duration of sleep bouts during the day. RES demonstrated a similar effect, albeit to a lesser extent compared to GSKE. All three dietary interventions led to a reduction in Aβ42 levels and an extension of the lifespan in Aβ42 flies, with GSEE showing the least pronounced effects. Furthermore, GSEE and RES were able to reverse the hyperexcitability of mushroom body neurons (MBNs) caused by Aβ42 expression. These results suggest that GSKE and RES are potent promoters of sleep and have the potential to ameliorate sleep disturbances. Additionally, the study highlights that other bioactive component in GSKE, beyond RES, may contribute to its diverse pharmacological activities, which could differ from those of GSEE or RES alone. This underscores the multifaceted nature of grape extracts and their potential therapeutic applications in addressing sleep disorders and neurodegenerative conditions associated with Aβ deposition.

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Resveratrol and Sir2 Reverse Sleep and Memory Defects Induced by Amyloid Precursor Protein

Cited by 4 publications

References 53 publications

Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Stand Up to Stand Out: Natural Dietary Polyphenols Curcumin, Resveratrol, and Gossypol as Potential Therapeutic Candidates against Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Potential mechanisms of action of resveratrol in prevention and therapy for mental disorders

Grape extract and resveratrol mitigate sleep fragmentation, Aβ accumulation, and abnormal neuronal excitability in aDrosophilamodel of Alzheimer’s disease

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