Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Ding, Shibin; Jiang, Jinjin; Zhang, Guofu; Bu, Yongjun; Zhang, Guanghui; Zhao, Xin

doi:10.1371/journal.pone.0183541

Cited by 144 publications

(116 citation statements)

References 51 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Based on CR experimen cytokine, chemokine, and metabolic pathways are significantly regulated by CR the aging process. It is expected that a better understanding of senoinflam mechanisms will provide a basis for the discovery of molecular targets that modulate age-related chronic inflammatory conditions and enable the develop effective interventions to delay aging and prevent the occurrence of aging-assoc ├ Human, Mouse, Rat [252][253][254] Autophagy ↑ and mice without SIRT3 genes have decreased HB concentration during fasting [1 are also related to low levels of insulin [213,214], suppressed IGF signaling [215], i [209] and activation of AMPK [215,216] and antioxidant genes [209]. K neuroprotective and lifespan extension effects similar to CR in C. elegans [21 transcription of antioxidant genes, including manganese superoxide dismu FOXO3, both of which exert antioxidant effects [209].…”

Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

View full text Add to dashboard Cite

Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Surprisingly, metformin failed to extend lifespan in Drosophila although it activates AMPK and reduces lipid accumulation [141]. Resveratrol, a natural polyphenol antioxidant, has been found to extend lifespan in C. elegans, Drosophila, zebrafish, mice and rats [91,[142][143][144]. The longevity benefits of resveratrol are dependent on sirtuins, FOXOs and AMPK [124,142,145].…”

Section: Discussionmentioning

confidence: 99%

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Jiang

Yan

Feng

et al. 2019

Cells

View full text Add to dashboard Cite

Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal. However, the molecular mechanisms by which DR confers benefits on longevity were not yet fully elucidated. The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and proliferation. The activity of FOXOs is also mediated by AMP-activated protein kinase (AMPK), sirtuins and the mammalian target of rapamycin (mTOR). Therefore, the FOXO-related pathways form a complex network critical for coordinating a response to environmental fluctuations in order to maintain cellular homeostasis and to support physiological aging. In this review, we will focus on the role of FOXOs in different DR interventions. As different DR regimens or calorie (energy) restriction mimetics (CRMs) can elicit both distinct and overlapped DR-related signaling pathways, the benefits of DR may be maximized by combining diverse forms of interventions. In addition, a better understanding of the precise role of FOXOs in different mechanistic aspects of DR response would provide clear cellular and molecular insights on DR-induced increase of lifespan and health-span.

show abstract

“…Caloric restriction is a strategy to decrease the energy supply by reducing the caloric intake from the diet without causing malnutrition (Ding et al, 2017;Li, Zhang, Liu, Chen, & Chen, 2017). This strategy has been used in several organisms from yeast to mammals, increasing lifespan, and maintaining health by delaying agingrelated diseases such as diabetes, cardiovascular diseases, cancer, and dementia (Ma, Wang, Dong, & Zhao, 2018;Willcox & Willcox, 2014).…”

Section: Re S Ver Atrol Supplementation Mimi C S the Effec Ts Of C mentioning

confidence: 99%

Resveratrol cytotoxicity is energy‐dependent

2019

View full text Add to dashboard Cite

Resveratrol is a phytochemical that may promote health. However, it has also been reported to be a toxic compound. The molecular mechanism by which resveratrol acts remains unclear. The inhibition of the oxidative phosphorylation (OXPHOS) pathway appears to be the molecular mechanism of resveratrol. Taking this into account, we propose that the cytotoxic properties of resveratrol depend on the energy (e.g., carbohydrates, lipids, and proteins) availability in the cells. In this regard, in a condition with low energy accessibility, resveratrol could enhance ATP starvation to lethal levels. In contrast, when cells are supplemented with high quantities of energy and resveratrol, the inhibition of OXPHOS might produce a low‐energy environment, mimicking the beneficial effects of caloric restriction. This review suggests that investigating a possible complex relationship between caloric intake and the differential effects of resveratrol on OXPHOS may be justified. Practical applications A low‐calorie diet accompanied by significant levels of resveratrol might modify cellular bioenergetics, which could impact cellular viability and enhance the anti‐cancer properties of resveratrol.

show abstract

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Cited by 144 publications

References 51 publications

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Resveratrol cytotoxicity is energy‐dependent

Contact Info

Product

Resources

About