Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice

Soliman, Rabie; Ismail, Ola A; Badr, Mohamed; Nasr, Sami Mohamed

doi:10.1016/j.exppara.2017.02.008

Cited by 28 publications

(29 citation statements)

References 59 publications

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“…Zhao et al studied different concentrations of RSV in a rat model of Alzheimer's disease and showed that administration of 40 and 80 mg/kg/d of RSV for 12 weeks suppressed the expression of RAGE . The results of two studies on mice indicated that oral administration of 20 mg/kg/d of RSV for 2 weeks downregulated the expression of RAGE . However, two human studies showed inconsistent results for the effects of RSV on glycation reactions and expression of RAGE .…”

Section: Resultsmentioning

confidence: 99%

“…37 The results of two studies on mice indicated that oral administration of 20 mg/kg/d of RSV for 2 weeks downregulated the expression of RAGE. 34,39 However, two human studies showed inconsistent results for the effects of RSV on glycation reactions and expression of RAGE. 41 30 days decreased the gene expression but not the serum concentration of RAGE.…”

Section: Effects Of Rsv On the Expression Of Age Receptorsmentioning

confidence: 99%

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The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

et al. 2019

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Accumulation of advanced glycation end products (AGEs) promotes the generation of free radicals, which leads to chronic oxidative stress predisposing to chronic oxidative stress, inflammation, and related diseases. This systematic review aimed to determine the effect of resveratrol (RSV) on AGE‐induced toxicity and its deleterious consequences. A comprehensive search was performed through literature were published until December 2018 using relevant keywords. The databases that were used for the search were PubMed, Scopus, Embase, ProQuest, and Google Scholar. A total of 29 eligible studies were found and included in the review for the analysis. Except one, all studies showed suppressing effects for RSV on the production of AGEs or receptor for advanced glycation end products (RAGE) and its detrimental consequences including oxidative stress, inflammatory response, cellular immune reactions, insulin response, and atherosclerosis. RSV exerts its effects through influencing RAGE, nuclear factor kappa B (NF‐κB), peroxisome proliferator‐activated receptor (PPAR) γ, and transforming growth factor (TGF)‐β activities. This review suggests that RSV has got potential to decrease AGEs toxicity and inhibit the AGE‐induced complications. More clinical trials are suggested to evaluate the beneficial effect of RSV on AGEs in chronic metabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Effects Of Rsv On the Expression Of Age Receptorsmentioning

confidence: 99%

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

et al. 2019

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“…Again, our results corroborate recent evidence about the use of polyphenolic compounds as potential therapeutic tools against protozoa and viruses, albeit scarce information is available on farm animals. Some dietary polyphenols (e.g., quercetin, resveratrol, rutin) show a certain efficacy against leishmaniosis [90], and giardiasis [91]; furthermore, resveratrol itself has been suggested as a potential restorative agent against toxoplasmosis brain disorders [92] and Schistosoma mansoni infections [93]. As far as the effects on viruses, human and animal evidence suggest polyphenolic compounds (e.g., resveratrol, tea polyphenols) possess potential preventive and therapeutic effects, and might be used as adjuvant therapy for the management of viral infection, e.g., influenza, herpes simplex, pseudorabies, hepatitis C, porcine reproductive and respiratory syndrome, and even Ebola [88,[94][95][96][97].…”

Section: Discussionmentioning

confidence: 99%

Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows

Pauletto

Elgendy

Ianni

et al. 2020

Animals

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The increasing demand for more animal products put pressure on improving livestock production efficiency and sustainability. In this context, advanced animal nutrition studies appear indispensable. Here, the effect of grape pomace (GP), the polyphenol-rich agricultural by-product, was evaluated on Holstein-Friesian cows’ whole-blood transcriptome, milk production and composition. Two experimental groups were set up. The first one received a basal diet and served as a control, while the second one received a 7.5% GP-supplemented diet for a total of 60 days. Milk production and composition were not different between the group; however, the transcriptome analysis revealed a total of 40 genes significantly affected by GP supplementation. Among the most interesting down-regulated genes, we found the DnaJ heat-shock protein family member A1 (DNAJA1), the mitochondrial fission factor (MFF), and the impact RWD domain protein (IMPACT) genes. The gene set enrichment analysis evidenced the positive enrichment of ‘interferon alpha (IFN-α) and IFN-γ response’, ‘IL6-JAK-STAT3 signaling’ and ‘complement’ genes. Moreover, the functional analysis denoted positive enrichment of the ‘response to protozoan’ and ‘negative regulation of viral genome replication’ biological processes. Our data provide an overall view of the blood transcriptomic signature after a 60-day GP supplementation in dairy cows which mainly reflects a GP-induced immunomodulatory effect.

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“…Also, it might be attributed to the antioxidant properties of AG in many tissues like renal tissue [16], RBCs in sickle cell anemia (SCA) disease [19] and hepatic tissue as mentioned by Ahmed et al, [45] who stated that AG significantly decreased the level of hepatic enzymes, lipid peroxidation, antioxidant enzymes as well as the expression of oxidative stress genes. Activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), which may contribute to the alleviation of Schistosoma mansoni infection consequences similar to what has been reported in many other antioxidants like gold nanoparticles Ceratonia siliqua pod extract [46], limonin [47]. Another theoretically potential mechanism of AG action relies on the fact that its administration enhances butyric acid production in the bowel and hence rising its serum concentration [13].…”

Section: Discussionmentioning

confidence: 77%

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Selem

Rashed

Younis

et al. 2018

Preprint

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Abstract. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018; 26Schistosomiasis is one of the most socioeconomically exhausting parasitic 27 infection in tropical and subtropical areas. Praziquantel (PZQ), the only common 28 schistosocidal drug in use, is not efficient enough for treatment of immature infection. 29Arabic gum (AG) is a complex polysaccharide acts as anti-oxidant which modulates the Author summary 46Schistosomiasis is a major public health threat in many parts of the world, it 47 affects more than 240 million people in more than 70 countries and almost 800 million 48 people are at risk of acquiring this disease. Serious consequences and disabilities might . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018;

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Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice

Cited by 28 publications

References 59 publications

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

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