Resveratrol ameliorates ortho- polychlorinated biphenyls’ induced toxicity in ovary cells

Miletić, Marina; Kmetič, Ivana; Kovač, Veronika; Šimić, Branimir; Petković, Tea; Štrac, Dubravka Švob; Pleadin, Jelka; Murati, Teuta

doi:10.1007/s11356-023-27812-6

Cited by 1 publication

(2 citation statements)

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“…The results showed that RSV differentially affects cell proliferation and viability in PCB-treated ovarian cells. At low concentrations (<10 µM), cell proliferation and metabolic activity were enhanced, and RSV exerted a protective effect against PCB 153-induced toxicity, whereas these events were reversed at higher concentrations [28]. Compared to RSV, the novel RF showed promising results in terms of improved biological activity and cell protection against PCB 153 toxicity at all concentrations tested (up to 100 µM).…”

Section: Discussionmentioning

confidence: 99%

“…NR and MTT assays showed the ameliorative effect of RF (in PCB 153-treated cells) at doses ≥ 20 µM, while KB was observed at doses ≥ 35 µM (Figure 2A-C). Recently, our group published a study [28] investigating the effect of RSV on toxicity induced by PCBs in CHO-K1 cells. The results showed that RSV differentially affects cell proliferation and viability in PCB-treated ovarian cells.…”

Section: Discussionmentioning

confidence: 99%

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Novel Ferrocene-Containing Triacyl Derivative of Resveratrol Protects Ovarian Cells from Toxicity Caused by Ortho-Substituted Polychlorinated Biphenyls

Kmetič,

Murati,

Kovač

et al. 2024

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Polychlorinated biphenyls (PCBs) can induce neurotoxicity, immunotoxicity, reproductive toxicity, genotoxicity, and carcinogenicity (IARC group 1 Carcinogens). Scientific data suggest that resveratrol possesses the ability to attenuate ortho-PCB-induced toxicity. Recently, a novel ferrocene-containing triacyl derivative of resveratrol (RF) was synthesized and in this study, its potential to protect CHO-K1 cells from selected PCB congeners (75 µM) was evaluated. Cell viability/proliferation was observed by Trypan Blue (TB), Neutral Red (NR), Kenacid Blue (KB), and MTT bioassays, ROS formation by fluorescent probes, and the extent of apoptosis by flow cytometry. All applied bioassays confirmed that RF (2.5–100 μM) remarkably improves viability in PCB 153-treated cells with an increase in cell survival almost up to control levels. This effect was not determined after PCB 77 exposure, although ROS formation was decreased at RF ≥ 50 µM. Apoptosis was significant (p < 0.05) for both congeners. In PCB 77-treated cells, RF did not suppress the induction of cell death. The intended protective effect of RF was evident when cells were treated with PCB 153, and this correlates with results obtained for cell viability. Compared to resveratrol, the novel RF showed promising results in terms of improved biological activity and cell protection against PCB 153 toxicity at all concentrations tested.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%