Resveratrol ameliorates diabetes‐related metabolic changes via activation of AMP‐activated protein kinase and its downstream targets in <i>db/db</i> mice

Do, Gyeong-Min; Jung, Un Ju; Park, Hae-Jin; Kwon, Eun‐Young; Jeon, Seon-Min; McGregor, Robin A.; Choi, Myung‐Sook

doi:10.1002/mnfr.201200067

Cited by 133 publications

(96 citation statements)

References 51 publications

(65 reference statements)

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“…Recent studies have demonstrated that resveratrol (trans-3,5,49-trihydroxy stilbene), which is found in red grapes and blue berries, lowers blood sugar, improves lipid profile 14 and prevents developmental delays in embryos of diabetic rats. 15 Several clinical trials have been conducted to study the metabolic effects of resveratrol in diabetics.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Yao¹,

Wan²,

Qiu³

et al. 2013

Asian J Androl

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The high incidence of erectile dysfunction (ED) in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin (65 mg kg 21 )-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), p53 and forkhead transcription factor O 3a (FOXO3a), superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was downregulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SIRT1 and restored erectile function. In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Yao¹,

Wan²,

Qiu³

et al. 2013

Asian J Androl

View full text Add to dashboard Cite

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“…1) Recently, resveratrol has been proposed as a potential anti-metabolic syndrome compound because of its role in activating sirtuin and AMP-activated protein kinase (AMPK). [2][3][4][5] Indeed, several studies have shown that resveratrol protects mice against diet-induced obesity. [6][7][8] Resveratrol has also been shown to have a favorable effect on glucose metabolism in humans.…”

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confidence: 99%

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Uchida-Maruki

Inagaki

Ito

et al. 2015

Biological & Pharmaceutical Bulletin

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We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3′,4′-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4′-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorates diet-induced obesity and insulin resistance. However, it is not known whether piceatannol also affects diet-induced obesity. We explored the effect of piceatannol on high fat diet-fed mice. The results showed that piceatannol did not affect high fat diet-induced body weight gain or visceral fat gain in mice. However, piceatannol did reduce fasting blood glucose levels. Furthermore, to explore the potential of passion fruit seed extract containing piceatannol as a functional food, passion fruit seed extract was administered in a genetic diabetic mouse model (db/db mice). Single administration of passion fruit seed extract, as well as piceatannol reduced the blood glucose levels of these db/db mice. These results suggest that piceatannol and passion fruit seed extract may have potential application in the prevention of diabetes.Key words piceatannol; passion fruit seed; antidiabetic activity; high fat diet; db/dbThe incidence of metabolic syndrome is increasing worldwide due to aging and changes in lifestyle. In particular, this increase is largely attributed to the rise in the prevalence of obesity, and this common metabolic disorder is associated with increased risk of cardiovascular diseases and type II diabetes, and the latter substantially decreases quality of life and increases health care costs. It is difficult to strictly control blood glucose levels over the long term, even though many anti-diabetic medications are clinically available. Therefore, the development of functional foods that can prevent or improve type II diabetes is an urgent matter.Resveratrol is a natural component of several plants, including grapes, berries, and peanuts. Resveratrol displays widespread functions and has several health-promoting effects owing to its anti-cancer, anti-inflammation, and antioxidant activity.1) Recently, resveratrol has been proposed as a potential anti-metabolic syndrome compound because of its role in activating sirtuin and AMP-activated protein kinase (AMPK).2-5) Indeed, several studies have shown that resveratrol protects mice against diet-induced obesity.6-8) Resveratrol has also been shown to have a favorable effect on glucose metabolism in humans.9,10) However, it should be noted that no weight loss has been reported after resveratrol treatment in any human study. 11)Piceatannol is a hydroxylated analog of resveratrol and is also found in various plants, including grapes and rhubarb. Although piceatannol shows activities similar to resveratrol, its levels in plants are significantly lower than those of resveratrol, 12) and it has therefore received far less research attention. We previously found that passion...

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“…Moreover, Gonzales & Orlando 13 found that resveratrol acts on the NF-κB of adipocytes by inhibiting IKK, which prevents the translocation of NF-κB to the nucleus and consequently, reduces the transcription of inflammatory genes 13 . Other studies found that resveratrol reduces IKK phosphorylation in rats' liver 32 and expression of NF-κB and the cytokines IL-1β and IL-6 in fibroblasts 33 . In addition to its effect on the insulin pathway, SIRT1 can deacetylate and consequently, inhibit NF-κB, thereby reducing the transcription of proinflammatory genes 34 .…”

Section: Discussionmentioning

confidence: 91%

Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obeserats

et al. 2014

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A B S T R A C T ObjectiveTo evaluate the effects of resveratrol on insulin signaling and inflammation pathway in the myocardium of high-fat diet-induced obese rats. MethodsThirty Wistar rats were divided into a control group (n=10, standard diet), obese group (n=10, high-fat diet), and obese supplemented with resveratrol group (n=10, 20 mg/kg/day) for eight weeks. An insulin tolerance test was performed at the end of the study period "0" (without insulin), 5, 10, 15, 20, 25, and 30 minutes after an intraperitoneal injection of insulin (2 U/kg). Body and epididymal adipose tissue were weighed. Fragments of the myocardium were extracted for Western blot analyses of insulin pathway and proinflammatory molecules. ResultsResveratrol increased the rate of glucose disappearance, phosphorylation of the insulin receptor, insulin receptor substrate 1, and protein kinase B; and reduced expression of tumor necrosis factor alpha and of the molecules

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Resveratrol ameliorates diabetes‐related metabolic changes via activation of AMP‐activated protein kinase and its downstream targets in db/db mice

Abstract: RV potentiates improving glycemic control, glucose uptake, and dyslipidemia, as well as protecting against pancreatic β-cell failure in a spontaneous type 2 diabetes model. Dietary RV has potential as an antidiabetic agent via activation of AMPK and its downstream targets.

Cited by 133 publications

References 51 publications

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obeserats

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