Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

Ali, Sajid; Madhana, Rajaram Mohanrao; Athira, K; Kasala, Eshvendar Reddy; Bodduluru, Lakshmi Narendra; Pitta, Sathish; Mahareddy, Jalandhar Reddy; Lahkar, Mangala

doi:10.1016/j.steroids.2015.05.010

Cited by 121 publications

(75 citation statements)

References 39 publications

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“…A treatment with corticosterone for 3 wk was used to induce a model of depression in mice, which highlights the potential for depression to be activated by the stress response (10)(11)(12)(13). Consistent with previous reports (10-13), our results show that corticosterone treatment increases the expression of depression-like behaviors.…”

Section: Discussionsupporting

confidence: 91%

“…However, chronic high concentrations of corticosterone induce attenuation of neurogenesis, abnormal function and morphology of neurons, and behavioral abnormalities (8,9). It has been reported that corticosterone administration increases the expression of depression-like behaviors (10)(11)(12)(13). Thus, we investigated whether collagen hydrolysate is effective in a stress-induced mouse model of depression where mice were administered corticosterone for 21 d.…”

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confidence: 99%

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Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice

Maekawa

Nogimura

Nagai

et al. 2019

J Nutr Sci Vitaminol

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Collagen is the most abundant protein in animals. Collagen hydrolysate has been found to have multiple functions in the skin, bones, joints, muscles, and blood vessels. Recently, it has been reported that the low molecular weight fraction of collagen hydrolysate exhibited anxiolytic activity, suggesting that collagen peptides affect brain functions. In the present study, we found that oral administration of ginger-degraded collagen hydrolysate (GDCH) significantly decreased depression-like behavior in a forced swim test, suggesting that GDCH exhibited antidepressant activity in mice. The antidepressant activity of GDCH was abolished by pre-treatment with an antagonist of the dopamine receptor, but not treatment with a serotonin receptor antagonist. GDCH significantly increased gene expression of glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in the hippocampus, molecules that affect the differentiation and survival of neurons, relative to that in the control condition. Meanwhile, there were no changes in the gene expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3, major factors related to depression-like behavior. We also found that GDCH exhibited antidepressant activity in corticosterone-administered mice in a model of stress. In addition, GDCH increased GDNF and CNTF expression in the stressed condition, suggesting that mechanisms of the antidepressant activity of GDCH were the same in unstressed and stressed conditions. These results imply that GDCH exhibits antidepressant activity in unstressed and stressed conditions in mice. The upregulation of neurotrophic genes in the hippocampus may contribute to the reduction of depression-like behavior via a dopamine signal pathway modulated by GDCH.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice

Maekawa

Nogimura

Nagai

et al. 2019

J Nutr Sci Vitaminol

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“…As reported recently, in order to reach a 1.8- to 2-fold increase of the blood corticosterone concentration in mice after 21 days, a dose of 40 mg/Kg/day would be required (Ali et al, 2015; Weng et al, 2016). In our experiment, the designed pellet delivery was close to 20 mg/Kg/day and the increase of the measured plasma corticosterone concentration was 1.5-fold compared to PL group.…”

Section: Discussionmentioning

confidence: 99%

Changes in C57BL6 Mouse Hippocampal Transcriptome Induced by Hypergravity Mimic Acute Corticosterone-Induced Stress

Pulga¹,

Porte²,

Morel³

2016

Front. Mol. Neurosci.

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Centrifugation is a widely used procedure to study the impact of altered gravity on Earth, as observed during spaceflights, allowing us to understand how a long-term physical constraint can condition the mammalian physiology. It is known that mice, placed in classical cages and maintained during 21 days in a centrifuge at 3G gravity level, undergo physiological adaptations due to hypergravity, and/or stress. Indeed, an increase of corticosterone levels has been previously measured in the plasma of 3G-exposed mice. Corticosterone is known to modify neuronal activity during memory processes. Although learning and memory performances cannot be assessed during the centrifugation, literature largely described a large panel of proteins (channels, second messengers, transcription factors, structural proteins) which expressions are modified during memory processing. Thus, we used the Illumina technology to compare the whole hippocampal transcriptome of three groups of C57Bl6/J mice, in order to gain insights into the effects of hypergravity on cerebral functions. Namely, a group of 21 days 3G-centrifuged mice was compared to (1) a group subjected to an acute corticosterone injection, (2) a group receiving a transdermal chronic administration of corticosterone during 21 days, and (3) aged mice because aging could be characterized by a decrease of hippocampus functions and memory impairment. Our results suggest that hypergravity stress induced by corticosterone administration and aging modulate the expression of genes in the hippocampus. However, the modulations of the transcriptome observed in these conditions are not identical. Hypergravity affects per-se the hippocampus transcriptome and probably modifies its activity. Hypergravity induced changes in hippocampal transcriptome were more similar to acute injection than chronic diffusion of corticosterone or aging.

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Section: Resveratrolmentioning

confidence: 99%

“…Preclinical studies have shown the antidepressant-like effect of resveratrol in various rodent models including the corticosterone-induced depression in mice (Ali et al 2015) and the Wistar-Kyoto rat model of depression (Hurley et al 2014). Moreover, in both cases, the antidepressant effect of resveratrol was associated with an increase in hippocampal BDNF (Hurley et al 2014; Ali et al 2015). Interestingly, resveratrol also prevented depression and the impaired cognition induced by chronic unpredictable mild stress in rats, and resulted in an increase in hippocampal BDNF (Ge et al 2013; Liu et al 2014b).…”

Section: Resveratrolmentioning

confidence: 99%

Duality of Antidepressants and Neuroprotectants

Tizabi

2015

Neurotox Res

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The co-morbidity of neuropsychiatric disorders, particularly major depressive disorder (MDD) with neurodegenerative diseases, in particular Parkinson’s disease (PD) is now well recognized. Indeed, it is suggested that depressive disorders, especially in late life, may be an indication of latent neurodegeneration. Thus, it is not unreasonable to expect that deterrents of MDD may also deter the onset and/or progression of the neurodegenerative diseases including PD. In this review, examples of neuroprotective efficacy of established as well as prospective antidepressants are provided. Conversely, mood-regulating effects of some neuroprotective drugs are also presented. Thus, in addition to currently used antidepressants, ketamine, nicotine, curcumin, and resveratrol are discussed for their dual efficacy. In addition, potential neurobiological substrates for their actions are presented. It is concluded that pharmacological developments of mood-regulating or neuroprotective drugs can have cross benefit in co-morbid conditions of neuropsychiatric and neurodegenerative disorders and that inflammatory and neurotrophic factors play important roles in both conditions.

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Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

Cited by 121 publications

References 39 publications

Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice

Ginger-Degraded Collagen Hydrolysate Exhibits Antidepressant Activity in Mice

Changes in C57BL6 Mouse Hippocampal Transcriptome Induced by Hypergravity Mimic Acute Corticosterone-Induced Stress

Duality of Antidepressants and Neuroprotectants

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