Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling

Banerjee, Bhaswati; Nandi, Pinki; Chakraborty, Supriya; Raha, Sanghamitra; Sen, Parimal C.; Jana, Kuladip

doi:10.1016/j.jnutbio.2016.04.003

Cited by 60 publications

(49 citation statements)

References 56 publications

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“…Indeed, the HP1γ (a marker for cellular senescence) was significantly downregulated in stress-challenged and resveratrol-recovered cells. These findings are supported by earlier studies that have reported anti-stress effects of resveratrol in different stress models and assays [36,[40][41][42]. Furthermore, we found that the cells treated in PREP mode showed better recovery, suggesting that the resveratrol may be useful for prophylactic therapy and improving the quality of life.…”

Section: Discussionsupporting

confidence: 91%

Anti-Stress, Glial- and Neuro-Differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays

et al. 2020

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Environmental stress, exhaustive industrialization and the use of chemicals in our daily lives contribute to increasing incidence of cancer and other pathologies. Although the cancer treatment has revolutionized in last 2-3 decades, shortcomings such as (i) extremely high cost of treatment, (ii) poor availability of drugs, (iii) severe side effects and (iv) emergence of drug resistance have prioritized the need of developing alternate natural, economic and welfare (NEW) therapeutics reagents. Identification and characterization of such anti-stress NEW drugs that not only limit the growth of cancer cells but also reprogram them to perform their specific functions are highly desired. We recruited rat glioma-and human neuroblastoma-based assays to explore such activities of resveratrol, a naturally occurring stilbenoid. We demonstrate that nontoxic doses of resveratrol protect cells against a variety of stresses that are largely involved in age-related brain pathologies. These included oxidative, DNA damage, metal toxicity, heat, hypoxia, and protein aggregation stresses. Furthermore, it caused differentiation of cells to functional astrocytes and neurons as characterized by the upregulation of their specific protein markers. These findings endorse multiple bioactivities of resveratrol and encourage them to be tested for their benefits in animal models and humans.

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Section: Discussionsupporting

confidence: 91%

Anti-Stress, Glial- and Neuro-Differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays

et al. 2020

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“…The mitogen‐activated protein kinases (MAPKs), a family of serine/threonine kinases, mainly include ERK1/2, p38, and JNK, with each MAPK signaling pathway consisting of at least three components . Activation of the MAPK signaling pathways plays a role in steroidogenesis, and multiple exogenous factors can affect the MAPK cascade reactions, affecting the expression of StAR, 3 β ‐HSD and 17 β ‐HSD, to ultimately perturb the levels of testosterone . Importantly, Ni can decrease the expression of StAR, CYP11A1, 3 β ‐HSD, and CYP17A1 via activation of ERK1/2 and p38 MAPK pathways, leading to the suppression of testosterone production in Leydig cells …”

Section: Introductionmentioning

confidence: 99%

Nano‐selenium attenuates nickel‐induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague‐Dawley rats

Gan

Zhang

Qiannan

et al. 2019

Environmental Toxicology

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The aim of this study was to investigate the protective effects of Nano-Se against Ni-induced testosterone synthesis disorder in rats and determine the underlying protective mechanism. Sprague-Dawley rats were co-treated with Ni (5.0 mg/kg, i.p.) and Nano-Se (0.5, 1.0, and 2.0 mg/kg, oral gavage) for 14 days after which various endpoints were evaluated. The Ni-induced abnormal pathological changes and elevated 8-OHdG levels in the testes were attenuated by Nano-Se administration.Importantly, decreased serum testosterone levels in the Ni-treated rats were significantly restored by Nano-Se treatment, particularly at 1.0 and 2.0 mg/kg. Furthermore, the mRNA and protein levels of testosterone synthetase were increased by Nano-Se compared to the Ni group, whereas phosphorylated protein expression levels of mitogen-activated protein kinase (MAPK) pathways were suppressed by Nano-Se administration in the Ni-treated rats. Overall, the results suggest that Nano-Se may ameliorate the Ni-induced testosterone synthesis disturbance via the inhibition of ERK1/2, p38, and JNK MAPK pathways.

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“…The apoptosis of hippocampal neuron cells impairs cognition and increases anxiety in patients with depressive disorder (37,38). It has been demonstrated that resveratrol treatment can inhibit testicular dysfunction and apoptosis via involvement of the p38 mitogen-activated protein kinase/activating transcription factor 2/inducible nitric oxide synthase signaling pathway (39). Resveratrol has also been reported to improve hippocampal atrophy in mice with chronic fatigue by enhancing neurogenesis and inhibiting the apoptosis of granular cells (40).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellularï¿½signal-regulated kinase/cAMP signal transduction pathway

Wang

et al. 2018

Mol Med Report

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Depressive disorder is a mental health disorder caused by the dysfunction of nerve regeneration, neuroendocrine and neurobiochemistry, which frequently results in cognitive impairments and disorder. Evidence has shown that resveratrol offers benefits for the treatment of depressive disorder. In the present study, the therapeutic effects of resveratrol were investigated and the potential mechanisms mediated by resveratrol were analyzed in hippocampal neuron cells. The anti‑oxidative stress and anti‑inflammatory properties of resveratrol were also examined in vitro and in vivo. The results revealed that resveratrol administration inhibited the inflammation in hippocampal neuron cells induced by ouabain. Oxidative stress in the hippocampal neuron cells was ameliorated by resveratrol treatment in vitro and in vivo. In addition, the apoptosis of hippocampal neuron cells was inhibited by the upregulation of anti‑apoptotic genes, including P53, B‑cell lymphoma‑2 (Bcl‑2) and Bcl‑2‑associated death promoter, and the downregulation of the cleaved caspase‑3 and caspase‑9. The analysis of the mechanism revealed that that resveratrol treatment suppressed the apoptosis of hippocampal neuron cells through the NETRIN1‑mediated extracellular signal‑regulated kinase/cAMP signal transduction pathway. The results of the in vivo assay showed that resveratrol treatment led to improvements in cognitive competence, learning memory ability and anxiety in a mouse model of depressive disorder induced by ouabain. In conclusion, these results indicated that resveratrol treatment had protective effects against oxidative stress and neuroinflammatory pathogenesis through the NETRIN1‑mediated extracellular signal‑regulated kinase/cAMP signal transduction pathway, suggesting that resveratrol treatment may be a potential antidepressant agent for the treatment of depressive disorder.

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Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling

Cited by 60 publications

References 56 publications

Anti-Stress, Glial- and Neuro-Differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays

Anti-Stress, Glial- and Neuro-Differentiation Potential of Resveratrol: Characterization by Cellular, Biochemical and Imaging Assays

Nano‐selenium attenuates nickel‐induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague‐Dawley rats

Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellularï¿½signal-regulated kinase/cAMP signal transduction pathway

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