Resveratrol alleviates enterotoxigenic<i>Escherichia coli</i>K88-induced damage by regulating SIRT-1 signaling in intestinal porcine epithelial cells

Luo, Xin; Wu, Shizhe; Hai, Jian; Si, Xuemeng; Song, Zhuan; Zhai, Zhian; Bai, Jun; Li, Jun; Yang, Ying; Wu, Zhenlong

doi:10.1039/d1fo03854k

Cited by 11 publications

(6 citation statements)

References 78 publications

(99 reference statements)

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“…Moreover, Sirt 1 and Parkin have been proven to play vital roles in mitophagy, which is involved in the immune response caused by pathogenic bacteria. 41 In the current study, the expression levels of the Sirt 1 and Parkin genes in the jejunal mucosa of broilers in the B. licheniformis treatment group were enhanced significantly compared with those in the CP-challenged group, indicating that B. licheniformis may mitigate the intestinal immune response by regulating the mitophagy response mediated by Sirt 1 signalling. However, the specific mechanism requires further research.…”

Section: Discussionsupporting

confidence: 48%

“…Furthermore, treatment with 500 mg kg −1 B. licheniformis significantly down‐regulated the expression of TLR4 , NF‐κB , NLRP3 , Caspase 1 , TNF‐α , IL‐1β and IL‐18 in the jejunal mucosa of CP ‐challenged broilers, suggesting that B. licheniformis may improve the intestinal immune response by regulating the activation of the TLR4/NF‐κB signalling pathway and NLRP3 inflammasome. Moreover, Sirt 1 and Parkin have been proven to play vital roles in mitophagy, which is involved in the immune response caused by pathogenic bacteria 41 . In the current study, the expression levels of the Sirt 1 and Parkin genes in the jejunal mucosa of broilers in the B. licheniformis treatment group were enhanced significantly compared with those in the CP ‐challenged group, indicating that B. licheniformis may mitigate the intestinal immune response by regulating the mitophagy response mediated by Sirt 1 signalling.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The protective effects of Bacillus licheniformis against inflammatory responses and intestinal barrier damage in broilers with necrotic enteritis induced by Clostridium perfringens

Zhang

Qin²,

Yang

et al. 2023

J Sci Food Agric

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BackgroundBacillus licheniformis is a gram‐positive bacterium that has strong environmental adaptability and can improve the growth performance, immunity, and antioxidant function of broilers. The current study aimed to elucidate the protective capability of B. licheniformis against inflammatory responses and intestinal barrier damage in broilers with necrotic enteritis (NE) induced by Clostridium perfringens (CP).ResultsThe results showed that B. licheniformis enhanced the final body weight in broilers compared with that of broilers in the CP group after the stress of infection (P < 0.05). Bacillus licheniformis reversed the decreased levels of serum and jejunum mucosa immunoglobulins and anti‐inflammatory cytokines, reduced the values of villus height and the ratio of villus height to crypt depth, and mitigated the increased levels of serum d‐lactic acid and diamine oxidase in CP‐challenged broilers (P < 0.05). Moreover, B. licheniformis modulated the expression levels of genes involved in the TLR4/NF‐κB signalling pathway, the NLRP3 inflammasome activation pathway, and the sirt 1/Parkin signalling pathway in CP‐challenged broilers. Compared with the CP challenge group, the B. licheniformis‐treated group exhibited reduced abundance values of Shuttleworthia and Alistipes and enhanced abundance values of Parabacteroides in the caecal contents (P < 0.05).ConclusionBacillus licheniformis improved the final body weight and alleviated the inflammatory response and intestinal barrier function damage in birds with NE induced by CP by maintaining intestinal physiological function, enhancing immunity, regulating inflammatory cytokine secretion, modulating the mitophagy response, and increasing the abundance of beneficial intestinal flora. © 2023 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

The protective effects of Bacillus licheniformis against inflammatory responses and intestinal barrier damage in broilers with necrotic enteritis induced by Clostridium perfringens

Zhang

Qin²,

Yang

et al. 2023

J Sci Food Agric

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“…Ahmed et al [ 14 ] showed that dietary resveratrol improved the IgG content in weaned piglets challenged with Salmonella typhimurium and E. coli . In vitro resveratrol alleviated E. coli K88 infection-induced damage, including decreased cell viability, reduced tight junctions, mitochondrial dysfunction, and autophagy in the porcine intestinal epithelial cell by activating SIRT1 signaling [ 132 ]. For viruses, resveratrol treatment relieved the inflammation response by inhibiting the TNF-α production and inhibited rotavirus infection by enhancing the IFN-γ content and CD4 + /CD8 + ratio, decreasing the diarrhea index [ 103 ].…”

Section: Application Of Resveratrol In Swine Productionmentioning

confidence: 99%

Biological function of resveratrol and its application in animal production: a review

Meng

Wang

et al. 2023

J Animal Sci Biotechnol

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With the prohibition of antibiotics in feed, plant functional substances have been widely studied as feed additives. Resveratrol, a natural stilbene, and a non-flavonoid polyphenol found in plants, possesses antioxidant, anti-inflammatory, and metabolic regulatory features. Resveratrol generated intense scientific and public interest, primarily due to its widely reported ability to prevent cancer, delay aging and alleviate related metabolic diseases. Recently, resveratrol has been studied and applied as a feed additive in animal production. This review focuses on the outline of the absorption and metabolism and biological functions of resveratrol and summarizes the application of dietary resveratrol in animal production up to the present, including pigs, poultry, and ruminants. In pigs, dietary resveratrol improved intestinal health, mitochondrial function, meat quality, and more. In poultry, studies have shown that dietary resveratrol improves growth performance and meat and egg quality and alleviates heat stress induced adverse effects. There are few studies on dietary resveratrol in ruminants; however previous studies have indicated that dietary resveratrol increases nutrient digestibility and reduces methane emissions in sheep. It is hoped that this review could provide a specific theoretical basis and research ideas for the research and application of resveratrol.

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“…Interestingly, AQP3 silencing inhibited cell viability and autophagy in gastric cancer cells while AQP3 overexpression activated autophagy via Krüpper like factor 5 as confirmed by chromatin immunoprecipitation and dual luciferase reporter assays ( Dai et al, 2023 ). Moreover, increasing data has indicated that ETEC infection caused significant autophagy in porcine intestinal epithelial cells ( Tang et al, 2014 ; Xia et al, 2019 ; Luo et al, 2022 ). In addition to ETEC, a recent study showed that PEDV induced autophagy in Vero CCL81 cells ( Ren et al, 2022 ).…”

Section: Role and Regulation Of Aqp3 In Intestinal Oxidative Stress A...mentioning

confidence: 99%

Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review

Zhu,

Nie,

et al. 2023

Front. Physiol.

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Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we systematically summarized the current understanding of the expression of AQP3 in the intestine of different species, and focused on the potential roles of AQP3 in water transport, different types of diarrhea and constipation, intestinal inflammation, intestinal barrier function, oxidative stress, and autophagy. These updated findings have supported that AQP3 may function as an important target in maintaining gut health of human and animals.

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Resveratrol alleviates enterotoxigenicEscherichia coliK88-induced damage by regulating SIRT-1 signaling in intestinal porcine epithelial cells

Abstract: This study found that resveratrol pretreatment attenuated the porcine intestinal epithelial cell damage caused by enterotoxigenic Escherichia coli (ETEC) K88 in vitro and the protective effects of resveratrol were associated...

Cited by 11 publications

References 78 publications

The protective effects of Bacillus licheniformis against inflammatory responses and intestinal barrier damage in broilers with necrotic enteritis induced by Clostridium perfringens

The protective effects of Bacillus licheniformis against inflammatory responses and intestinal barrier damage in broilers with necrotic enteritis induced by Clostridium perfringens

Biological function of resveratrol and its application in animal production: a review

Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review

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