Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R

Cui, Yuanyuan; Li, Yuting; Ning, Jiayi; Mi, Yajing; Wang, Xiaolong; Qiu, Zhongying; Li, Le; Gou, Xin

doi:10.3892/mmr.2020.11157

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…In addition, thermal hyperalgesia and mechanical allodynia are known as the most common forms of DNP. In 2020, Cui et al investigated the effects of RSV on diabetic mechanical allodynia (DMA)-related behaviors in rats ( 133 ). The results confirmed that the RSV had a dose-dependent analgesic effect on DMA model rats.…”

Section: Resveratrol Effects On Diabetic Complicationsmentioning

confidence: 99%

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Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review

Koushki,

Farahani,

Yekta

et al. 2024

Food & Nutrition Research

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Background: Diabetes mellitus (DM) is a category of metabolic conditions affecting about 5% of people worldwide. High mortality associated with DM is mostly due to its severe clinical complications, including diabetic nephropathy, retinopathy, neuropathy, and cardiomyopathy. Resveratrol (RSV) is a natural, biologically active polyphenol known to have various health-promoting effects in animal models and humans. Objective: In this review, we have reviewed the preventive and therapeutic role of RSV on diabetes complications with emphasis on its molecular mechanisms of action. Methods: To prepare this review, all the basic and clinical available literatures regarding this topic were gathered through electronic databases, including PubMed, Web of Science, Scopus, and Google Scholar. Therefore, we summarized previous studies that have evaluated the effects of RSV on diabetic complications and their mechanisms. Only English language studies published up to January 2023 were included in this review. Results: RSV improves glucose homeostasis, decreases insulin resistance, induces autophagy, regulates lipid metabolism, protects pancreatic β-cells, ameliorates metabolic disorders, and increases the GLUT4 expression. These effects induced by RSV are strongly associated with ability of this polyphenol agent to elevation expression/activity of AMP-activated protein kinase and Sirtuin 1 in various organs of diabetic subjects, which leads to prevention and therapy of diabetic complications. In addition, antioxidant and anti-inflammatory properties of RSV were reported to be involved in its action in diabetic complications, such as retinopathy and nephropathy. Conclusion: RSV is a promising compound for improving diabetic complications. However, the exact antidiabetic mechanisms of RSV need to be further investigated

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Section: Resveratrol Effects On Diabetic Complicationsmentioning

confidence: 99%

“…The results confirmed that the RSV had a dose-dependent analgesic effect on DMA model rats. In addition, downregulation of P2X3R expression in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) might be the potential mechanism of RSV analgesic effects on DMA-related behaviors ( 133 ).…”

Section: Resveratrol Effects On Diabetic Complicationsmentioning

confidence: 99%

Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review

Koushki,

Farahani,

Yekta

et al. 2024

Food & Nutrition Research

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“…In Polygonum cuspidatum, resveratrol (RES) relieves pain in peripheral and central inflammatory diseases by decreasing arachidonic acid metabolism [80]. In addition, RES suppressed neuropathic pain transmission in DRG satellite glial cells and relieved mechanical hyperalgesia in rats treated with gp120 by inhibiting P2X3R and P2X7R [81][82][83][84]. Astragalin therapy has been reported to be able to reduce neuropathic pain by blocking P2X4-mediated signaling in rat DRG [85].…”

Section: Active Ingredients Of Tcms For Painful Diseases Management Via P2x3r and P2x7rmentioning

confidence: 99%

Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment

Dong

Guo

et al. 2021

Purinergic Signalling

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Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play important roles in many diseases. Activation of P2 receptors (P2R) channels and subsequent membrane depolarization can induce accumulation of extracellular ATP, and furtherly cause kinds of diseases, such as pain-and immune-related diseases, cardiac dysfunction, and tumorigenesis. Active ingredients of traditional Chinese herbals which exhibit superior pharmacological activities on diversified P2R channels have been considered as an alternative strategy of disease treatment. Experimental evidence of potential ingredients in Chinese herbs targeting P2R and their pharmacological activities were outlined in the study.

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Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury

Üstündağ,

Kara,

Doğanay

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Sepsis is a life-threatening condition characterized by a systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain a challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle–enhanced resveratrol (AgNP-RV) as treatments for sepsis-induced lung injury using a rat model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). The study focused on evaluating changes in oxidative status (TAS, TOS, and OSI) and the expression of inflammatory and apoptotic markers (IL-1β, TNF-α, P2X7R, TLR4, Caspase-3, and Bcl-2) in lung tissue. Both RV and AgNP-RV demonstrated potential in mitigating oxidative stress, inflammation, and apoptosis, with AgNP-RV exhibiting greater efficacy than RV alone (p < 0.05). These findings were corroborated by histopathological analyses, which revealed reduced tissue damage in the RV- and AgNP-RV-treated groups. Our study highlights the therapeutic potential of RV and, particularly, AgNP-RV in combating sepsis-induced oxidative stress, inflammation, and apoptosis. It also underscores the promise of nanoparticle technology in enhancing therapeutic outcomes. However, further investigations are warranted to fully understand the mechanisms of action, especially concerning the role of the P2X7 receptor in the observed effects. Nonetheless, our research suggests that RV and AgNP-RV hold promise as novel strategies for sepsis management.

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Resveratrol alleviates diabetic mechanical allodynia in rats by downregulating P2X3R

Cited by 5 publications

References 37 publications

Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review

Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review

Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment

Molecular mechanisms of resveratrol and its silver nanoparticle conjugate in addressing sepsis-induced lung injury

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