Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies

Ibrahim, Khairy A.; Abdelgaid, Hala A.; Eleyan, Mohammed; Mohamed, Rania Ali El Hadi; Gamil, Noha M.

doi:10.1016/j.lfs.2021.120265

Cited by 10 publications

(6 citation statements)

References 78 publications

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“…In 2009, Elif Tatlidede et al demonstrated that RSV treatment notably raised cardiac GSH contents and suppressed oxidant responses in DOX-processed rats; Simultaneously, it ameliorated DOX-induced deterioration of cardiac function and myocardial injury [192]. In the following decade, many researchers verified in various models of myocardial injury that RSV can exert an antioxidant effect and protect the myocardium by increasing the level of GSH and upregulating the activity of GSH-dependent antioxidant enzymes [193][194][195][196][197]. Moreover, they revealed that the mechanism by which RSV enhances the GSH system involves the AMPK signaling pathway, the Nrf2 signaling pathway, the Sirt1 pathway, noncoding RNA (miR-149) and the KAT5 gene [193][194][195][196][197].…”

Section: Glutathione System Activatormentioning

confidence: 99%

“…In the following decade, many researchers verified in various models of myocardial injury that RSV can exert an antioxidant effect and protect the myocardium by increasing the level of GSH and upregulating the activity of GSH-dependent antioxidant enzymes [193][194][195][196][197]. Moreover, they revealed that the mechanism by which RSV enhances the GSH system involves the AMPK signaling pathway, the Nrf2 signaling pathway, the Sirt1 pathway, noncoding RNA (miR-149) and the KAT5 gene [193][194][195][196][197]. In addition, RSV can suppress the occurrence of ferroptosis in the myocardium by increasing SLC7A11/GSH and GPX4 [193,195].…”

Section: Glutathione System Activatormentioning

confidence: 99%

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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Tan

Yin

et al. 2023

Cell Death Dis

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The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury. Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury. Moreover, in facing various pathological challenges, the mammalian heart, which possesses high levels of mitochondria and weak antioxidant capacity, is susceptible to oxidant production and oxidative damage. Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy. In this review, we first systematically describe the physiological functions and anabolism of the GSH system, as well as its effects on cardiac injury. Then, we discuss the relationship between the GSH system and ferroptosis in myocardial injury. Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches.

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Section: Glutathione System Activatormentioning

confidence: 99%

Section: Glutathione System Activatormentioning

confidence: 99%

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Tan

Yin

et al. 2023

Cell Death Dis

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“…In vitro studies demonstrated that this (poly)phenol can directly scavenge a variety of oxidants, including hydroxyl radical, superoxide, and hydrogen peroxide ( Xia et al, 2017 ). Resveratrol treatment showed to improve the levels of glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and acetylcholinesterase (AchE) ( Ibrahim et al, 2022 ) as well as a 14-fold increase of SOD function that, by reducing superoxide, restores mitochondrial function ( Diaz-Gerevini et al, 2016 ) ( Figure 2 ). Due to the hydrophobic properties of resveratrol, it is likely that its activity is mediated by binding to hydrophobic pockets in proteins.…”

Section: Potential Pharmacological Effects Of Resveratrol and Mechani...mentioning

confidence: 99%

“…Similar results demonstrated that resveratrol can inhibit ROS-induced cell death by stimulating AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) alpha pathway ( Li et al, 2017a ; Huang et al, 2021 ). Recent studies have demonstrated that resveratrol can exert its cardioprotective role through the modulation of the SIRT1/c-Jun N-terminal kinase (c-JNK)/p53 pathway ( Ibrahim et al, 2022 ) or through the indirect activation of SIRT1 modulating different pathways such as the inhibition of phosphodiesterase (PDE) and subsequent elevation of cellular nicotinamide adenine dinucleotide (NAD + ) ( Park et al, 2012 ), by enhancing the binding of SIRT1 to lamin A ( Liu et al, 2012 ) or by the upregulation of SIRT1 expression ( Csiszar et al, 2009 ; Xia et al, 2013 ). Resveratrol can directly interact with SIRT1 ( Howitz et al, 2003 ; Hubbard et al, 2013 ) as well as increase its activity by rising the intracellular NAD + concentration, which is dependent on phosphodiesterase (PDE) inhibition, leading to the phosphorylation of AMPK ( Park et al, 2012 ), or enhancing the binding of SIRT1 to lamin A ( Liu et al, 2012 ; Park et al, 2012 ; Alexander et al, 2015 ).…”

Section: Potential Pharmacological Effects Of Resveratrol and Mechani...mentioning

confidence: 99%

Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota

Godos,

Romano,

Gozzo

et al. 2024

Front. Pharmacol.

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Cardiovascular diseases are among the leading causes of mortality worldwide, with dietary factors being the main risk contributors. Diets rich in bioactive compounds, such as (poly)phenols, have been shown to potentially exert positive effects on vascular health. Among them, resveratrol has gained particular attention due to its potential antioxidant and anti-inflammatory action. Nevertheless, the results in humans are conflicting possibly due to interindividual different responses. The gut microbiota, a complex microbial community that inhabits the gastrointestinal tract, has been called out as potentially responsible for modulating the biological activities of phenolic metabolites in humans. The present review aims to summarize the main findings from clinical trials on the effects of resveratrol interventions on endothelial and vascular outcomes and review potential mechanisms interesting the role of gut microbiota on the metabolism of this molecule and its cardioprotective metabolites. The findings from randomized controlled trials show contrasting results on the effects of resveratrol supplementation and vascular biomarkers without dose-dependent effect. In particular, studies in which resveratrol was integrated using food sources, i.e., red wine, reported significant effects although the resveratrol content was, on average, much lower compared to tablet supplementation, while other studies with often extreme resveratrol supplementation resulted in null findings. The results from experimental studies suggest that resveratrol exerts cardioprotective effects through the modulation of various antioxidant, anti-inflammatory, and anti-hypertensive pathways, and microbiota composition. Recent studies on resveratrol-derived metabolites, such as piceatannol, have demonstrated its effects on biomarkers of vascular health. Moreover, resveratrol itself has been shown to improve the gut microbiota composition toward an anti-inflammatory profile. Considering the contrasting findings from clinical studies, future research exploring the bidirectional link between resveratrol metabolism and gut microbiota as well as the mediating effect of gut microbiota in resveratrol effect on cardiovascular health is warranted.

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“…The usage of antioxidants to protect from oxidative injury induced by pesticides has recently developed as an important way to hinder the construction of ROS [11]. Garlic, Allium sativum, is conventionally used for both culinary and medicinal purposes [12].…”

Section: Introductionmentioning

confidence: 99%

Garlic and allopurinol alleviate the apoptotic pathway in rats’ brain following exposure to fipronil insecticide

Bakr

Desouky

Ibrahim

2022

Environ Anal Health Toxicol

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Fipronil can cause oxidative tissue damage and apoptosis. Our goal is to evaluate the antiapoptotic impact of garlic or allopurinol against fipronil neurotoxicity. Thirty-six mature male albino rats were separated into control, garlic aqueous extract (500 mg/kg), allopurinol (150 mg/L in their drinking water), fipronil (13.277 mg/kg), garlic+fipronil, and allopurinol+fipronil. Our results revealed that fipronil induced a significant increase in brain malondialdehyde, protein carbonyl levels as well as enzymatic antioxidant activities (superoxide dismutase, catalase, glutathione peroxidase, and xanthine oxidase), but glutathione-S-transferase recorded a significant decrease as compared to the control. In addition, fipronil significantly up-regulated the brain pro-apoptotic (Bax) and caspase -3 mRNA gene expression and induced DNA fragmentation but caused down-regulation in anti-apoptotic (Bcl-2) mRNA genes expression. Interestingly, co-administration with garlic or allopurinol improved the lipid peroxidation, antioxidant disturbance, and apoptosis induced by fipronil in the brain tissues. In conclusion, garlic or allopurinol reduced fipronil-induced apoptosis and reduced oxidative tissue damage, most likely through enhancing the tissue antioxidant defense system.

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Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies

Cited by 10 publications

References 78 publications

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota

Garlic and allopurinol alleviate the apoptotic pathway in rats’ brain following exposure to fipronil insecticide

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