Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

“…Moreover, in rat pancreatic islets, resveratrol attenuated glucose-induced hyperpolarization of the inner mitochondrial membrane [19]. In the isolated adipocytes, resveratrol was recently found to reduce the release of glucosederived CO 2 and to inhibit glucose conversion to lipids [25]. In this study, resveratrol disturbed oxidative metabolism of glucose, as evidenced by increased formation of lactate.…”

Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

“…The effects of resveratrol on lipolysis have been studied in vitro, ex vivo, and in vitro [40,41]. One study demonstrated that resveratrol (100 μM) failed to promote lipolysis in epididymal adipocytes of rat [40].…”

“…The effects of resveratrol on lipolysis have been studied in vitro, ex vivo, and in vitro [40,41]. One study demonstrated that resveratrol (100 μM) failed to promote lipolysis in epididymal adipocytes of rat [40]. Another study suggested that treatment of resveratrol (100 μM) for 12, 24, or 48 hr significantly promoted lipolysis in 3T3-L1 adipocytes and also exerted synergistic action with epinephrine [41].…”

Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

“…Although little is known about the role of piceatannol in lipid metabolism, resveratrol has been shown to inhibit total fatty acid and triglyceride synthesis in adipocytes (51,52). Current evidence also suggests a role for resveratrol in stimulating lipolysis and fatty acid oxidation in adipocytes (53)(54)(55). Thus, it will be of interest to determine the role of piceatannol in lipid synthesis and hydrolysis in adipose tissue.…”