Resveratrol: A Focus on Several Neurodegenerative Diseases

Abstract

Molecules of the plant world are proving their effectiveness in countering, slowing down, and regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene structure has been proven to be a universal panacea, especially for a wide range of neurodegenerative diseases. This paper evaluates (in vivo and in vitro) the various molecular targets of this peculiar polyphenol and its ability to effectively counter several neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's diseases and amyotrophic lateral sclerosis. What emerges is that, in the deep heterogeneity of the pathologies evaluated, resveratrol through a convergence on the protein targets is able to give therapeutic responses in neuronal cells deeply diversified not only in morphological structure but especially in their function performed in the anatomical district to which they belong.

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

“…In addition to thousands of research papers related to resveratrol, approximately 300 review articles have been published. Amongst other actions, resveratrol has been reported to exhibit anti-inflammatory and antifibrotic effects (Conte et al, 2015), antitumor activities (Han et al, 2015;Signorelli and Ghidoni, 2005), protection in renal disease (Albertoni and Schor, 2015) and neurodegeneration (Tellone et al, 2015), activity against obesity (de Ligt et al, 2015), diabetes (Szkudelski and Szkudelska, 2015), stroke (Nabavi et al, 2014), hepatic steatosis (Aguirre et al, 2014) and cardiovascular diseases (Tang et al, 2014).…”

Expanding the Repertoire of Dielectric Fractional Models: A Comprehensive Development and Functional Applications to Predict Metabolic Alterations in Experimentally-Inaccessible Cells or Tissues

“…In these cases, the dielectric properties of the blood change, and in particular, the partial polarization vectors associated with each anomalous phenomenon (disease) can change. It may be useful to study the dielectric properties of blood related to neurodegenerative diseases and the protective effects of some natural compounds [14][15][16][17][18]. Obviously, the investigation of these pathologies is very difficult if it is carried out by considering partial polarization directly, since a direct measure of them is very difficult.…”

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

“…PGC-1α deficiency has been implicated in the onset and progression of age-related neurodegenerative disorders (Tellone et al, 2015). Ectopic expression of PGC-1α Drosophila homologue delays aging and prolongs lifespan (Rera et al, 2011).…”