Resveratrol, a Component of Wine and Grapes, in the Prevention of Kidney Disease

Bertelli, A.; Migliori, Massimiliano; Panichi, Vincenzo; Origlia, Nicola; Filippi, C.; Das, Dipak K.; Giovannini, Luca

doi:10.1111/j.1749-6632.2002.tb02919.x

Cited by 51 publications

(41 citation statements)

References 26 publications

(24 reference statements)

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“…In previous studies, it has been established that black grape and tomato have high antioxidant contents (Alcolea et al, 2002;Bertelli et al, 2002;Weisburger, 2002) and can make a contribution to the antioxidant power in vivo (Ozturk et al, 1999;Visioli et al, 2003). However, results of the present study demonstrate that dried black grape can provide significant protection against cisplatininduced peroxidation reactions; tomato juice does also, but to a lesser extent.…”

Section: Discussioncontrasting

confidence: 76%

“…In previous studies, it has been established that dried black grape may strengthen the antioxidant potential of the body and thus reduce some oxidant stress-induced health problems (Ozturk et al, 1999;Bertelli et al, 2002). Similarly, it has been established in the previous studies that tomato also has antioxidant power due to its rich lycopene content (Stahl and Sies, 1996), and that its use may be helpful for the amelioration of some oxidant stress-related diseases (Agarwall and Rao, 2000).…”

Section: Introductionmentioning

confidence: 88%

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Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods

Çetin¹,

Devrım

Kilicoglu³

et al. 2005

J. Appl. Toxicol.

108

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This study aims to elucidate the molecular mechanism(s) of cisplatin nephrotoxicity and the possible protective effects of antioxidant food supplementation on this toxicity. Twenty eight rats were used throughout the study. Cisplatin was administered intraperitoneally (i.p.) in a single dose (10 mg kg(-1)). Antioxidant food supplementation was started 3 days before cisplatin treatment. In each group (control, cisplatin, cisplatin plus dried black grape and cisplatin plus tomato juice), there were seven animals. Rats were killed 72 h after treatment. The kidneys were removed and prepared for biochemical and histopathological investigations. Oxidant (sensitivity to oxidation, xanthine oxidase enzyme and malondialdehyde level) and antioxidant (superoxide dismutase, glutathione peroxidase and catalase enzymes, and antioxidant potential value) parameters were measured in kidney tissues of the groups. Histopathological examination was also performed. Significant decreases were measured in the renal activities of catalase and glutathione peroxidase enzymes. There was, however, a significant increase in the activity of xanthine oxidase enzyme in the cisplatin-treated animals compared with the control group. The kidney tissue malondialdehyde levels were found to be increased, but sensitivity to oxidation and antioxidant potential values to be decreased in the cisplatin group. In the food supplemented groups, it has been observed that black grape eliminated oxidant stress by increasing antioxidant potential, but tomato did not. Histopathological examination results also revealed significant damage in the kidney tissues from the cisplatin-treated rats. In the black grape group, significant improvements were observed compared with the cisplatin group. In the tomato group, there were also some improvements but to a lesser degree compared with the black grape group. The results suggest that cisplatin treatment causes significant oxidant load to the kidneys through both xanthine oxidase activation and impaired antioxidant defense system, which resulted in accelerated oxidation reactions in the kidney tissue. It is proposed that supplementation of some foods such as black grape which has resveratrol as an antioxidant can provide significant protection against cisplatin nephrotoxicity.

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 88%

Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods

Çetin¹,

Devrım

Kilicoglu³

et al. 2005

J. Appl. Toxicol.

108

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“…Several studies have examined the effects of resveratrol on peripheral organ systems and have reported that resveratrol can provide protection to the heart (8, 53) and kidney (7,43,52) and may inhibit carcinogenesis (24,34). In addition, others have reported that resveratrol may play a beneficial role in impaired vascular function of large peripheral blood vessels during type 1 (41,44) and type 2 (57) diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol has been reported to have a variety of pharmacological effects, including anti-inflammatory, anticarcinogenic, antioxidant, and antiplatelet properties (5,6,20,24,45,55,58). Several investigators have shown that resveratrol has both acute and chronic influences on organ systems (7,8,45,53) and endothelial function of large peripheral blood vessels during T1D (41, 44). The mechanisms that account for the effects of resveratrol on vascular function are varied but appear to involve an increase in the expression of eNOS, an increase in the expression of antioxidant pathways and pathways that might regulate antioxidant responses in cells (including SIRT1 and Nrf2), and/or a decrease in the expression of endothelin (13,22,41,44,47,53,58).…”

mentioning

confidence: 99%

Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats

Arrick

Sun

Patel

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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Arrick DM, Sun H, Patel KP, Mayhan WG. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Am J Physiol Heart Circ Physiol 301: H696-H703, 2011. First published June 10, 2011; doi:10.1152/ajpheart.00312.2011.-Decreased dilation of cerebral arterioles via an increase in oxidative stress may be a contributing factor in the pathogenesis of diabetes-induced complications leading to cognitive dysfunction and/or stroke. Our goal was to determine whether resveratrol, a polyphenolic compound present in red wine, has a protective effect on cerebral arterioles during type 1 diabetes (T1D). We measured the responses of cerebral arterioles in untreated and resveratrol-treated (10 mg·kg Ϫ1 ·day Ϫ1 ) nondiabetic and diabetic rats to endothelial (eNOS) and neuronal (nNOS) nitric oxide synthase (NOS)-dependent agonists and to a NOS-independent agonist. In addition, we harvested brain tissue from nondiabetic and diabetic rats to measure levels of superoxide under basal conditions. Furthermore, we used Western blot analysis to determine the protein expression of eNOS, nNOS, SOD-1, and SOD-2 in cerebral arterioles and/or brain tissue from untreated and resveratrol-treated nondiabetic and diabetic rats. We found that T1D impaired eNOS-and nNOSdependent reactivity of cerebral arterioles but did not alter NOSindependent vasodilation. While resveratrol did not alter responses in nondiabetic rats, resveratrol prevented T1D-induced impairment in eNOS-and nNOS-dependent vasodilation. In addition, superoxide levels were higher in brain tissue from diabetic rats and resveratrol reversed this increase. Furthermore, eNOS and nNOS protein were increased in diabetic rats and resveratrol produced a further increased eNOS and nNOS proteins. SOD-1 and SOD-2 proteins were not altered by T1D, but resveratrol treatment produced a decrease in SOD-2 protein. Our findings suggest that resveratrol restores vascular function and oxidative stress in T1D. We suggest that our findings may implicate an important therapeutic potential for resveratrol in treating T1D-induced cerebrovascular dysfunction.brain; N-methyl-D-aspartic acid; adenosine 5=-diphosphate; nitroglycerin; oxidative stress; superoxide CEREBRAL VASCULAR DISEASE leading to cognitive dysfunction and/or stroke is a complication of type 1 and type 2 diabetes. The risk of stroke is significantly higher in patients with diabetes than in persons without, and the mortality following a stroke is significantly higher in patients with diabetes compared with those without (4,25,37). Endothelial dysfunction appears to play an important role in the pathogenesis of vascular abnormalities during many disease states, including type 1 and type 2 diabetes (12,21,26,39,42). Many studies have shown that type 1 diabetes (T1D) affects endothelial cell function of large peripheral vessels by influencing the generation of nitric oxide via nitric oxide synthase (NOS) and/or via the formation of reactive oxygen species (11,23,36,38,40). In addition, we have sho...

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“…In previous work, red wine polyphenol resveratrol caused an attenuation of oxidative damage and decreased vulnerability of the kidney to ischaemiareperfusion damage [7,8]. Nevertheless, it is not well established whether this protection is mechanistically linked to the reported effects of the various wine components since these effects have not been separately studied.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine

Rodrigo¹,

Bosco²,

Herrera³

et al. 2004

Nephrology Dialysis Transplantation

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Background. Myoglobinuric acute renal failure causes increased oxidative stress. Since ethanol upregulates renal antioxidant enzymes and wine polyphenols behave as antioxidants, we tested the hypothesis that red wine components would ameliorate the renal damage caused by rhabdomyolysis. Methods. Adult rats received water (control), alcoholfree red wine, ethanol 12.5% (v/v) or red wine for 10 weeks. Rhabdomyolysis was induced by glycerol injection (50%, 10 ml/kg, i.m.), and urine and blood samples were collected 6 h later to measure renal function parameters, creatine kinase (CK) activity, free F 2 -isoprostanes and total antioxidant capacity. Kidneys were then harvested for morphological studies and determinations of lipid peroxidation, protein carbonylation, (Na þ K)-ATPase and antioxidant enzyme activities. Results. In the control group, myoglobinuria was associated with a 68% decrease in creatinine clearance and increases in plasma creatinine and blood urea nitrogen of 3.2 and 1.8 times above baseline, respectively. Controls also showed increases in plasma free F 2 -isoprostanes levels and CK activity, together with enhanced renal expression of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase, as well as increased production of malondialdehyde and carbonyls. Rhabdomolysis reduced renal (Na þ K)-ATPase activity and this reduction was associated with a 5-fold increase in fractional sodium excretion as well as morphological damage to the kidney. These changes were significantly attenuated by pretreatment with chronic red wine exposure prior to glycerol injection. A less marked degree of functional and biochemical protection was also observed in response to the administration of alcohol-free red wine and ethanol.Conclusions. The present data suggest that red wine protects against functional, biochemical and morphological damage caused by rhabdomyolysis in the rat, and this protection may be due to the synergistic effects of ethanol and non-alcoholic red wine components.

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Resveratrol, a Component of Wine and Grapes, in the Prevention of Kidney Disease

Cited by 51 publications

References 26 publications

Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods

Cisplatin impairs antioxidant system and causes oxidation in rat kidney tissues: possible protective roles of natural antioxidant foods

Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats

Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine

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