Resurgence of measles in Singapore: Profile of hospital cases

Goh, Denise; Chew, Fook Tim; Khor, Shuzin; Lee, B. W.

doi:10.1046/j.1440-1754.1999.355407.x

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…In such populations, susceptible groups include older individuals and young infants, because infants born to vaccinated mothers lose maternal antibodies at an early age [7,8]. Therefore, a bimodal age distribution, with peaks in the very young (below 18 months) and those aged 16-20 years, is observed [9]. As a consequence, changes in the epidemiology of SSPE can be expected.…”

Section: Introductionmentioning

confidence: 99%

Changing Epidemiological Features of Subacute Sclerosing Panencephalitis

et al. 2001

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Section: Introductionmentioning

confidence: 99%

Changing Epidemiological Features of Subacute Sclerosing Panencephalitis

et al. 2001

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“…When first introduced in the 1970s, the uptake rate of measles vaccination was low, as most people perceived that developing natural infection was an essential part of growing up. ( 13 ) Coverage gradually increased in the 1980s, especially after vaccination became compulsory in 1985, and it has been maintained at more than 90% since 1998 ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 97%

Singapore's efforts to achieve measles elimination in 2018

See

Cui

et al. 2021

WPSAR

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The World Health Organization verified that Singapore had eliminated endemic transmission of measles in October 2018. This report summarizes the evidence presented to the Regional Verification Commission for Measles and Rubella Elimination, comprising information about immunization schedules; laboratory testing protocols and the surveillance system; and data on immunization coverage and the epidemiology of cases. Between 2015 and 2017, a total of 246 laboratory confirmed cases of measles were reported. The source or country of infection was unknown for most cases (195; 79.3%). There were 22 clusters, ranging from two to five cases. The most common genotypes detected were D8 and D9. Transmission of B3 was interrupted in 2017, and H1 cases were sporadic and imported. Phylogenetic analyses of the D8 isolates showed the existence of 13 lineages or clusters. Although a few lineages were circulating concurrently, no lineage propagated continuously for a prolonged period, and transmission of each lineage eventually stopped. Although cases and clusters were reported yearly, molecular data showed that none of the lineages resulted in prolonged transmission. There were fewer measles cases in 2017 compared with 2016. The higher number of clusters was likely due to the overall increase in cases because cluster sizes remained small. The occurrence of small clusters is not unexpected since measles is highly infectious. The majority of imported cases did not result in secondary transmission. With the global increase in the number of measles cases, Singapore needs to stay vigilant and continue to promptly test suspected cases; vaccination is the key to preventing infection.

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“…An important observation was the significant rise in the Ab titre of the 15-year-old age group following the administration of an additional booster dose of the vaccine, compared to the 10-year-old age group (P < 0.00001) (Table 2). The necessity for an additional immunization is also emphasized in a report from Singapore [26] and in other countries [27,28]. Therefore, an additional dose of measles vaccine is recommended for Iranian children around high-school age.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of measles antibody in children of different ages in Shiraz, Islamic Republic of Iran

Karimi¹,

Arjomandi²,

Alborzi³

et al. 2004

East Mediterr Health J.

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An outbreak of measles due to secondary vaccine failure prompted this investigation into the prevalence of measles antibody in children. We studied 608 children in 7 different age groups:6, 9, 14 and 18 months and 6, 10 and 15 years. Children in the 2 youngest groups received no vaccination; the rest were vaccinated at 9 months and 15 months. The 15-year-old age group received an additional vaccination. Transplacental measles antibody [Ab] decreased from 10.0% at 6 months to 0% at 9 months. Measles Ab was positive in 52.9% [14 months], 89.4% [18 months], 60.8% 96 years], 45.0% [10 years] and 96.8% [15 years]. To increase Ab levels, a booster vaccination is recommended, administered either with the second DPT booster or at pre-high school age

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Resurgence of measles in Singapore: Profile of hospital cases

Cited by 4 publications

References 12 publications

Changing Epidemiological Features of Subacute Sclerosing Panencephalitis

Changing Epidemiological Features of Subacute Sclerosing Panencephalitis

Singapore's efforts to achieve measles elimination in 2018

Prevalence of measles antibody in children of different ages in Shiraz, Islamic Republic of Iran

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