ReSure Sealant for Pars Plana Vitrectomy Wound Closure

Ho, Vincent Y.; Shah, Gaurav K.; Liu, Enchun M.

doi:10.3928/23258160-20151027-09

Cited by 9 publications

(7 citation statements)

References 3 publications

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“…In this study, the biocompatibility of hydrogel samples was compared with that of control samples by assessing cytotoxicity, irritation, sensitization, pyrogen toxicity, and systemic toxicity, which are the most important factors in in vitro tests for wounds care 14 . According to the results of these analyses, the PEG-based hydrogel showed good biocompatibility and safety 15 . The animal study confirmed the effectiveness and convenience of using PEG-based hydrogels for wound closure and bleeding control and their enhanced performance over a commercial product.…”

Section: Discussionmentioning

confidence: 97%

A PEG-Based Hydrogel for Effective Wound Care Management

Chen

Liao

et al. 2018

Cell Transplant

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It is extremely challenging to achieve strong adhesion in soft tissues while minimizing toxicity, tissue damage, and other side effects caused by wound sealing materials. In this study, flexible synthetic hydrogel sealants were prepared based on polyethylene glycol (PEG) materials. PEG is a synthetic material that is nontoxic and inert and, thus, suitable for use in medical products. We evaluated the in vitro biocompatibility tests of the dressings to assess cytotoxicity and irritation, sensitization, pyrogen toxicity, and systemic toxicity following the International Organization for Standardization 10993 standards and the in vivo effects of the hydrogel samples using Coloskin liquid bandages as control samples for potential in wound closure.

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Section: Discussionmentioning

confidence: 97%

A PEG-Based Hydrogel for Effective Wound Care Management

Chen

Liao

et al. 2018

Cell Transplant

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“…Open globe injuries, which involve full‐thickness injuries to the cornea, sclera, or both, account for 10% of eye injuries occurring in the United States every year . There are currently limited U.S. Food and Drug Administration approved medical adhesives for closure of ocular penetrations . The feasibility of TAPTRA as an ocular adhesive to reversibly seal ocular injuries was further investigated in detail.…”

Section: Resultsmentioning

confidence: 99%

Reversible Bioadhesives Using Tannic Acid Primed Thermally‐Responsive Polymers

Whalen

Humayun

et al. 2019

Adv Funct Materials

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A two-layer approach is reported for the formation of a thermally triggered reversible adhesive, involving a thermally-responsive polymer matrix coated on tannic acid-pretreated substrates/tissues. Interfacial adhesion originates from strong molecular interactions of tannic acid with both the polymer matrix and the substrate/tissue. The reversibility is due to a temperaturetriggered phase transition of the polymer matrix, leading to cohesive failure. Depending on different gelation mechanisms, the polymer forms a highly cohesive gel or soft solid upon either warming or cooling, leading to a strong adhesion to the tissues at physiological temperatures. Detachment of the adhesive is triggered by a temperature-induced compromise of cohesive strength of the polymer matrix, by the opposite gel-to-sol transition. This facile, low-cost, and modular design offers a reversible adhesive platform which is useful for biomedical and industrial applications.

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“…A literature review reveals only one paper exploring ReSure’s applications beyond simple cataract surgery —a case report—documenting its use in closure of trocar ports in the setting of a pars plana vitrectomy. 6 Cataract and glaucoma are leading causes of visual impairment and are age-related processes which often co-occur. Both entities frequently require surgical intervention, and in many cases the requisite operations are performed simultaneously as a combined procedure.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel Sealant for Closure of Clear Corneal Incisions in Combined Glaucoma Procedures

Guduru¹,

Herndon²

2022

OPTH

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Purpose The purpose of this study is to determine whether ReSure hydrogel sealant is superior to standard suture for closure of clear corneal incisions in the setting of combined glaucoma procedures. Setting Glaucoma Department, Duke University Eye Center. Design This is a retrospective case series. Subjects studied were patients in a 6-year period undergoing combined phacoemulsification and glaucoma surgery. All cases were performed by the same surgeon. Wound closure methods correlated with discrete timeframes, as ReSure replaced suture midway through the study period, thereby establishing sutured closure as an analogous control group. Methods All cases included a phacoemulsification procedure requiring a 2.4 mm clear corneal incision. Upon completion of the phacoemulsification portion of the case, the wound was closed with either ReSure hydrogel or standard 10–0 suture closure. The researchers assessed the rate of Seidel-positive corneal wound leak on postoperative day one. Results In all cases employing ReSure, no wound leak was observed at postoperative day one. Within the suture group, 3 cases showed Seidel positivity of the corneal incision. This equates to a statistically significant difference in wound leak frequency of 2.04% (P = 0.012); confidence interval, 0.21 to 5.82. Conclusion ReSure was able to maintain closure 100% of the time over hundreds of combined cases. Suture, though the standard of practice, did not perform to this level, presenting with 3 cases of spontaneous wound leak. We conclude that ReSure is highly effective and superior to suture in closure of clear corneal incisions in combined glaucoma procedures.

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ReSure Sealant for Pars Plana Vitrectomy Wound Closure

Abstract: ReSure Sealant may be a safe, quick method to close sclerotomy wounds in select cases. [

Cited by 9 publications

References 3 publications

A PEG-Based Hydrogel for Effective Wound Care Management

A PEG-Based Hydrogel for Effective Wound Care Management

Reversible Bioadhesives Using Tannic Acid Primed Thermally‐Responsive Polymers

Hydrogel Sealant for Closure of Clear Corneal Incisions in Combined Glaucoma Procedures

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