Results of use of metformin and replacement of starch with saturated fat In diets of patients with type 2 diabetes

Effects of a Low-Carbohydrate Diet: In Response

“…Reduced appetite, nausea, and fatigue might be expected in patients with ketosis. 4 Our patients with polycystic ovary syndrome or reactive hypoglycemia and most of those with cardiovascular disease, 5 as well as patients reported previously with type 2 diabetes mellitus, 6 did not have ketosis. Therefore, as might be expected, these patients did not report having these symptoms.…”

Effect of a High Saturated Fat and No-Starch Diet on Serum Lipid Subfractions in Patients With Documented Atherosclerotic Cardiovascular Disease

“…26 The presence or absence of ketosis and its potential role in weight loss is of interest. Patients with type 2 diabetes, 5 PCOS, and RH (Table 3) treated in clinical practice had negative fasting urinary ketones, but only patients in this study had measurable levels of fasting serum BOHB. All 5 men who had elevated levels of BOHB also had detectable ketonuria, suggesting that urinary monitoring may be suffi-cient to avoid unintended ketosis; why these men became ketotic is unclear.…”

“…A diet of high saturated fat and avoidance of starch (HSF-SA) appeared to result in weight loss without adverse effects on serum lipid levels in a group of patients with type 2 diabetes. 5 These observations were difficult to interpret because of the use of multiple hypoglycemic and lipidlowering drugs, which were changed on the basis of clinical judgment. 4 In our study, patients with polycystic ovary syndrome (PCOS) and reactive hypoglycemia (RH) also appeared to have sustained weight loss without significant changes in serum lipid levels despite taking no lipid-lowering medications.…”

Effects of Dairy Protein and Fat on the Metabolic Syndrome and Type 2 Diabetes

“…However, Kuipers et al suggest that reduction of carbohydrates with a high glycemic index may be more efficient in the prevention of CVD induced by low-grade inflammation [79]. Furthermore, substitution of starch with SFA is found to improve glycemic control in T2D subjects [80]. Besides the interaction with other macronutrients, SFA may also modulate the susceptibility to impaired insulin sensitivity, and may cause MetS in genetically disposed individuals [81].…”