Results of treatment in irradiated testicular seminoma patients

Kellokumpu‐Lehtinen, Pirkko; Halme, A.

doi:10.1016/0167-8140(90)90017-q

Cited by 18 publications

(3 citation statements)

References 17 publications

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“…Testicular cancer is very chemosensitive (5) and seminomas are also extremely radiosensitive (6). Testicular cancer is very chemosensitive (5) and seminomas are also extremely radiosensitive (6).…”

mentioning

confidence: 99%

Management of Testicular Cancer: 16 years' Experience from Southwest Finland

Sundström

Salminen

Nurmi

et al. 2001

Scandinavian Journal of Urology and Nephrology

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confidence: 99%

Management of Testicular Cancer: 16 years' Experience from Southwest Finland

Sundström

Salminen

Nurmi

et al. 2001

Scandinavian Journal of Urology and Nephrology

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“…Adjuvant radiation therapy after inguinal orchiectomy has resulted in excellent local control. After five years, recurrence, free survival and cause-specific survival are consistently reported at 95% and 98-99%, respectively [17, 18]. Doses reductions from 30 Gy to 20 Gy were achieved without compromising outcomes [19].…”

Section: Discussionmentioning

confidence: 99%

Adjuvant Radiotherapy for Synchronous Bilateral Testicular Seminoma: A Case Report and a Review of the Pertinent Literature

Jones

Ester

Leavitt

et al. 2013

Case Reports in Urology

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Few cases of synchronous bilateral stage I seminomas have been reported in the world literature. We present a case of bilateral synchronous testicular seminoma, the current literature on the management of stage I seminoma, and the implications for radiotherapy. A forty-year-old man presented with synchronous bilateral classical seminomas, both stage IA. After undergoing bilateral inguinal orchiectomy, he received adjuvant external beam radiotherapy, with a standard paraaortic field. After 18 months of followup, he remains well, without evidence of recurrence. Bilateral germ cell tumors (BGCTs) are reported consistently at a low rate. Bilateral radical inguinal orchiectomy is standard of care, yet some groups have proposed an organ preservation approach. Of the reported cases of bilateral stage I synchronous GCT, with concordant seminoma histology, most of them were treated with bilateral orchiectomy and adjuvant radiotherapy. Although morbidity associated with radiotherapy directed at the abdomen is not negligible, adjuvant paraaortic radiotherapy remains safe and well-tolerated treatment regime. Bilateral synchronous stage I seminoma of the testes is rare. Organ preservation remains investigational. Chemotherapy is probably a reasonable option. We propose that patients with bilateral stage I synchronous GCT, with concordant seminoma histology, should be managed with bilateral orchiectomy, followed by paraaortic radiotherapy.

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“…The primary testicular lymphatic drainage is to the para-aortic nodes and the subsidiary lymphatics pass to the iliac and inguinal chains. In stage I diseases approximately 10-20% of patients have subclinical retroperitoneal lymph node metastases (5)(6)(7)(8)(9). There is no way of predicting the presence of micrometastases in these nodes, and because testicular seminomas spread in a sufficiently predictable manner, it is possible to encompass conveniently all known and suspected disease in an acceptable radiotherapeu- tic treatment volume.…”

Section: Discussionmentioning

confidence: 99%

Post‐orchiectomy management in stage I testicular seminoma: Elective irradiation or surveillance?

Singhal

Dixit

Vyas

et al. 1993

Australasian Radiology

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Fifty-six patients with stage I testicular seminoma were treated at this institute between January 1982 and December 1988. Post-orchiectomy elective radiotherapy to ipsilateral iliac-inguinal and para-aortic lymph nodes was delivered in 54 cases. An overall 3 year survival rate of 96% was observed in this series. Four patients (7%) relapsed (one junctional recurrence in iliac node region, two mediastinal/hilar nodes and one skeletal metastasis). Salvage chemotherapy proved successful in two out of three cases with nodal relapse. No dose limiting acute or late radiation related complications were noticed. No definite correlation was found between the patients who relapsed and various known adverse prognostic factors. We recommend elective irradiation of the draining lymph nodes in stage I seminoma, particularly at centres where surveillance is not feasible.

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Results of treatment in irradiated testicular seminoma patients

Cited by 18 publications

References 17 publications

Management of Testicular Cancer: 16 years' Experience from Southwest Finland

Management of Testicular Cancer: 16 years' Experience from Southwest Finland

Adjuvant Radiotherapy for Synchronous Bilateral Testicular Seminoma: A Case Report and a Review of the Pertinent Literature

Post‐orchiectomy management in stage I testicular seminoma: Elective irradiation or surveillance?

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