Results of three analytical approaches on long-term efficacy of etanercept for psoriasis in daily practice

Satisfaction of treatment with biologics is high in psoriasis: results from the Bio-CAPTURE network

“…In order to detect possible bias due to missing values or selection, two analyses were performed: (i) an intention-totreat (ITT) with last observation carried forward (ITT with LOCF) analysis, which represented the most conservative approach; and (ii) an as-treated analysis, which represented the most positive approach. 18 In the ITT with LOCF analysis, missing values for month 3, were imputed by baseline values; missing values for month 6 were imputed with month 3 values. To investigate the influence of prior experiences with biological treatments on TSQM, patients were classified as 'biologics-experienced' (prior treatment with biologics) or 'biologics-inexperienced' (no prior treatment with biologics).…”

“…For this reason, we performed analyses with and without imputation of missing data. 18 A specific difficulty of the TSQM is that there is an established threshold for meaningful changes. 7,12 Shikiar and Rentz argue that patients' expectations influence satisfaction with a drug.…”

Methotrexate in pediatric plaque-type psoriasis: Long-term daily clinical practice results from the Child-CAPTURE registry

“…Effectiveness analysis using PASI and BSA were performed in two ways: (1) according to an as-treated principle and (2) intention-to-treat analysis using last observation carried forward (LOCF) until 48 weeks in patients who discontinued MTX treatment (18). End of the treatment episode was defined as a discontinuation of MTX therapy during 12 weeks or more.…”

Polymorphisms inCD84,IL12BandTNFAIP3are associated with response to biologics in patients with psoriasis

“…We performed different analyses (LOCF, as treated) to test the robustness of our findings, and the results of both analyses were similar. 34 PASI scores at treatment start (baseline) can be influenced by earlier treatments. If a patient starts with a low PASI, the maximum ΔPASI is consequently small.…”

“…This leads to a more positive reflection of response; patients who remain in the 'as treated' analysis are usually responders. 34 We calculated for each agent and its given number of treatment episodes what SNP effects we were able to detect at alpha 0Á05 and with 80% power. We chose to reflect the SNP effect in terms of explained variance, a more intuitive measure, which is dependent on the combination of allele frequency and beta.…”