Results of the observational (non-interventional) research 'Analysis of therapeutic efficiency of the polyvalent Piobacteriophag (Secstaphag) in the treatment of acute sinusitis'

Кryukov, A. I.; Гуров, А. В.; Изотова, Г. Н.; Lapenko, E G

doi:10.17116/otorino20198405155

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Thirty-three percent of this population had a positive response, whereas 27.8% of patients with a low K rate had a positive response, suggesting that the level of phage neutralization does not affect the outcome of phage therapy. A few years later, a randomized controlled trial was conducted in Russia, comparing the efficacy of phage therapy to antibiotics in the treatment of acute rhinosinusitis [25]. Fifty patients with acute maxillary sinusitis were admitted to the day care hospital and underwent puncture and rinsing of the maxillary sinus.…”

Section: Efficacy Of Phage Therapy In Recalcitrant Crsmentioning

confidence: 99%

“…A sheep model demonstrated that local application of bacteriophages to the frontal sinuses is safe and does not damage the respiratory epithelium after 14 days of treatment [8,9,19]. Observational human clinical trials have demonstrated that, both oral and intranasal, phage therapy is generally well-tolerated and is not associated with serious adverse events, changes in blood values or changes in vital signs [10,[21][22][23][24][25].…”

Section: Interpretation Of the Available (Pre)clinical Datamentioning

confidence: 99%

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The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

et al. 2021

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Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

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Section: Efficacy Of Phage Therapy In Recalcitrant Crsmentioning

confidence: 99%

Section: Interpretation Of the Available (Pre)clinical Datamentioning

confidence: 99%

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

et al. 2021

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Phage therapy of purulent-inflammatory pathology of the outer and middle ear

Гуров¹,

Lapenko²,

Kryukov³

2022

Vestn. otorinolaringol.

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Prospects for the application of bacteriophages in the treatment of sinusitis caused by antibiotic-resistant bacterial strains

Kryukov,

Gurov,

Cherkasov

et al. 2023

Medicinskij sovet

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Purulent diseases in otorhinolaryngology are of great interest due to their widespread prevalence and the objective difficulties of treatment. One of the most frequently encountered nosological forms is purulent sinusitis. A key element in the complex treatment of bacterial sinusitis is systemic antibiotic therapy aimed at the eradication of pathobionts from the focus of infection. However, the increasing worldwide drug resistance of etiologically significant microorganisms complicates antibacterial chemotherapy of purulent sinusitis and raises questions about its future feasibility. The threat of a change from a resistance era to a post-antibiotic era is very significant, given the acute shortage of new antibiotics and the relatively rapid adaptation of bacterial microorganisms to them. The global community is therefore faced with the challenge of finding other drugs with antimicrobial activity. In recent decades, genetically modified virulent bacteriophages and phagolytes isolated on their basis are becoming increasingly attractive in the fight against purulent infections of various localizations caused by drug-resistant bacteria. This literature review focuses on the potential of phage therapy for acute bacterial sinusitis in an era of globally increasing bacterial strain resistance. The article details the causative agents of community-acquired and hospital-acquired acute sinusitis, the main mechanisms of bacterial antibiotic resistance, the effect of virulent phages on bacteria, and studies on the efficacy of phage therapy in the treatment of acute sinusitis. The facts outlined herein clearly indicate the efficacy of phage therapy, as well as therapeutic perspectives on using bacteriophages in the complex treatment of purulent sinusitis caused by antibiotic-resistant microbiota.

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Results of the observational (non-interventional) research 'Analysis of therapeutic efficiency of the polyvalent Piobacteriophag (Secstaphag) in the treatment of acute sinusitis'

Cited by 3 publications

References 7 publications

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Phage therapy of purulent-inflammatory pathology of the outer and middle ear

Prospects for the application of bacteriophages in the treatment of sinusitis caused by antibiotic-resistant bacterial strains

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