Results of surgical treatment of early gastric cancer in 113 patients

Gentsch, H. H.; Groitl, H.; Giedl, J

doi:10.1007/bf01657850

Cited by 36 publications

(14 citation statements)

References 10 publications

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“…Degree of differentiation has been found to either have no prognostic influence12 33 34 37 69 or, where a difference is detected, the differentiated/intestinal types have shown worse prognosis 1011 24 27 36 50 56 61 62 64 67 68Although this is a consistent finding, it contradicts the observation that less differentiated tumours are associated with deeper invasion and lymph node invasion. Old age seems to confer worse prognosis,11 36 50 even after multivariate analysis 67.…”

Section: Survival and Prognosismentioning

confidence: 90%

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Early gastric cancer in Europe

Everett

Axon

1997

Gut

276

157

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Despite mass population screening and an incidence of EGC in Japan that is at least double that of the West, there seem to be no genuine differences in the clinicopathological features of the disease between the two regions. The macroscopic appearance, size, depth of invasion, frequency of lymph node invasion, and histology of EGC are all remarkably similar in Japan, Europe and America, as are sex and age distributions.Patients with EGC are a number of years younger than those with advanced cancer. This is not surprising: Tsukuma et alfollowed 56 cases of EGC that were not surgically treated and estimated that the median “duration of EGC” before becoming advanced was 37 months.87 This suggests that EGC undergoes a period of slow growth before becoming advanced. Further differences between early and advanced cancers include a higher frequency of synchronous cancers and a longer symptom duration in EGC.Unfavourable prognostic factors in EGC include lymph node invasion, and invasion through the muscularis mucosae, though it is not clear whether these are independent. Repeated attempts have been made to identify other prognostic factors, but no clear pattern has emerged, with the possible exceptions of patient age, tumour size, and the presence of ulceration.The postsurgical outcome of EGC in the West is marginally less favourable than in Japan. In view of the similar clinical and pathological features in the two regions it seems likely, therefore, that this is because of the more aggressive surgical techniques traditionally used in Japan. Conversely, however, EMR has recently emerged as an important technique in Japan. Despite the advantages of low operative mortality and normal function of the postoperative stomach, there are also a number of potential disadvantages. It would seem sensible, therefore, to await the results of long term follow up studies before widespread adoption of EMR in Europe. Nevertheless, this technique should be considered for frail patients unfit for more radical surgery.

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Section: Survival and Prognosismentioning

confidence: 90%

“…Old age seems to confer worse prognosis,11 36 50 even after multivariate analysis 67. Larger tumour size has been associated with either no difference5 34 or with worse survival rates,37 65 and excavated/depressed tumours have been associated with a better prognosis 2433 39 56 67 …”

Section: Survival and Prognosismentioning

confidence: 99%

Early gastric cancer in Europe

Everett

Axon

1997

Gut

276

157

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“…Early gastric carcinoma is defined as gastric cancer in which cancer cell infiltration is restricted to the lamina propria mucosa or submucosal layers. 32 Although the prognosis for early gastric carcinoma is excellent, 33–36 there exists a type of early gastric cancer with poor prognosis due to its penetrating growth and early recurrence in the liver, called the PEN type, 37 particularly the PEN A type. The PEN type has a maximal diameter of 4 cm and invades the submucosa extensively and deeply, in contrast to the SUPER type which spreads only superficially.…”

Section: Genetic Model For Gastric Tumorigenesismentioning

confidence: 99%

Molecular biology of gastric carcinoma: From laboratory to bedside

Chan¹,

Luk

Hui³

et al. 1999

J of Gastro and Hepatol

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Although the advancement of molecular oncology in gastric cancer lags behind that of colorectal cancer, the rapid developments witnessed in recent years have improved our understanding of the carcinogenesis, aetiology, progression and metastasis of gastric cancer. The different molecular genetic alterations in intestinal and diffuse types of gastric cancer have further supported the concept that these two pathological types are different disease entities. The association of telomerase and cadherin changes with Helicobacter pylori infection reinforces its aetiological role. The mutated cadherin gene identified in familial gastric cancer has shone light onto the pathogenesis. Adhesion molecules have already been applied to daily clinical practice as prognostic markers. Future molecular studies will contribute to the screening, classification, disease monitoring and therapeutics of gastric cancer. © 1999 Blackwell Science Asia Pty Ltd

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“…As a result of increased diagnostic accuracy and the wider application of mass surveys, the proportion of early gastric cancer (EGC) among resected gastric cancers has steadily increased, not only in Asia, but also in some Western countries [1-6]. Although the prognosis of EGC is excellent [7-9], EGC with lymph node metastasis (LNM) has a higher possibility of recurrence [10-12].…”

Section: Introductionmentioning

confidence: 99%

Predicting lymph node status in patients with early gastric carcinoma using double contrast-enhanced ultrasonography

Xue

Huang²,

Aronow³

et al. 2011

aoms

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IntroductionDouble contrast-enhanced ultrasonography (DCUS) is a new method we used in predicting lymph node metastasis (LNM) in patients with early gastric cancer.Material and methodsSeventy-six patients with early gastric cancer diagnosed by gastroscope and confirmed by pathology after operation were examined using DCUS preoperatively. Group N1 included 15 patients with LNM and group N0 61 patients without LNM.ResultsIn group N1, 13 patients (87%) had marked hyperenhancement during early arterial phase using DCUS, and 2 patients (13%) were unmarked as hyperenhancement. In group N0, 24 patients (39%) had marked hyperenhancement during early arterial phase using DCUS, and 37 patients (61%) had unmarked hyperenhancement. The sensitivity and specificity of marked hyperenhancement in predicting LNM in patients with early gastric cancer was 86.7% and 60.7% respectively, and the Youden’s index was 0.474. The κ value of this method was 0.89.ConclusionsDouble contrast-enhanced ultrasonography is a new valuable method to evaluate LNM at an early stage of gastric cancer and prognosis of early gastric cancer preoperatively.

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Results of surgical treatment of early gastric cancer in 113 patients

Cited by 36 publications

References 10 publications

Early gastric cancer in Europe

Early gastric cancer in Europe

Molecular biology of gastric carcinoma: From laboratory to bedside

Predicting lymph node status in patients with early gastric carcinoma using double contrast-enhanced ultrasonography

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