Results of salvage abdominoperineal resection for recurrent anal carcinoma following combined chemoradiation therapy

Oncologic Outcomes of Salvage Surgery for Epidermoid Carcinoma of the Anus Initially Managed With Combined Modality Therapy

“…10,13 These include initial N2 nodal disease, tumor size at salvage, fixation of tumor to pelvic sidewall at salvage, and age at diagnosis. Interestingly, no studies have shown initial pre-CRT clinical T stage to be prognostic.…”

“…Studies reviewing the outcomes of salvage surgery after failed CRT are few and are comprised of small numbers. [9][10][11][12][13] The purpose of this study was to retrospectively review the Memorial SloanKettering Cancer Center (MSKCC) experience with salvage surgery for ECA, which, to our knowledge, is the largest experience to date in the surgical literature.…”

The versatility of the pedicled vertical rectus abdominis myocutaneous flap in oncologic patients

“…Recent studies with focus on perineal reconstruction after combined chemoradiation therapy proved the VRAM flap to be superior to omentum and gracilis flap reconstruction [44] as well as the thigh flap [33] with respect to wound healing. In our series, even patients with irradiation ulcers did not develop vessel-related complications, such as rupture or thrombosis.…”

Real world dehiscence rates for patients undergoing abdominoperineal resection with or without myocutaneous flap closure in the national surgical quality improvement project

“…This contradicts some prior studies though these may have been limited in generalizability due to small sample size and/or salvage indication [1,10,[22][23][24][25]. While a pathophysiologic mechanism for increased wound complications following neoadjuvant therapy certainly exists [26], the evidence for increased wound complications following neoadjuvant radiation has been conflicting.…”