Results of resection for bronchogenic carcinoma in patients over the age of 80

Lung cancer in octogenarians: factors affecting long-term survival following resection

“…Previous series reported 5-year survival rates ranging from 32% to 55% [1,2]. This wide range is likely due to a varying degree of three well-known confounding factors: (1) selection bias; (2) small sample sizes in each series (range 8-68); and (3) incompleteness of follow-up.…”

“…The conventional bias against surgical therapy in the elderly, and in octogenarians in particular, is being challenged as acceptable outcomes in selected cohorts have been reported [1][2][3][4][5][6][7][8][9]. In this special patient population, long-term outcome analysis is of paramount relevance since the predictable loss of physiologic reserve precludes easy extrapolation of survival data obtained in much younger populations.…”

“…Long-term survival following resection for lung cancer in octogenarians has been reported in multiple surgical series [1][2][3][4][5][6][7][8]. While studies have repeatedly shown that surgery remains the optimal treatment for patients who are deemed to have resectable disease, even in this age group, most reports include only small patient numbers, thus limiting their ability to identify factors predicting long-term survival.…”

Efficacy of functional operability algorithm for octogenarians with primary lung cancer

“…In all, 2565 (9.2%) of 27881 lung cancer patients who underwent surgery in 2008 were ≥ 80 years of age according to a survey conducted by the Japanese Association for Thoracic Surgery. 1 Although surgical results of the octogenarians with primary lung cancer have been reported, [2][3][4][5][6][7][8][9][10][11][12][13] it has also been shown that elderly patients are less likely to undergo surgical resection even for early stage lung cancer because of overestimation of the operative risk. 14, 15 We have been using a functional operability algorithm that includes an exercise test for all patients with potentially resectable lung cancer.…”

Stereotactic body radiotherapy using real-time tumor tracking in octogenarians with non-small cell lung cancer

“…In addition the projected life expectancy of octogenarians is on average >7 years [6,7]. Although 5-year survival rates after surgery in octogenarians are encouraging (34-57%) [8][9][10][11], careful patient selection is essential and postoperative morbidity and mortality are not negligible [10,12,13]. An alternative to surgery currently used to treat patients with inoperable stage I NSCLC is stereotactic body radiotherapy (SBRT).…”