Results of Rebiopsy for Suspected
Prostate Cancer in Symptomatic
Men with Elevated PSA Levels

Perachino, M.; Ciolo, L. Di; Barbetti, Valentina; Ardoino, Silvia Marina; Vitali, A.; Introini, Carlo; Vigliercio, G.; Puppó, P.

doi:10.1159/000480850

Cited by 42 publications

(7 citation statements)

References 10 publications

(19 reference statements)

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“…10,42,47 Incidence of PIN The incidence of PIN varies according to the population of men under study ( Table 2). [48][49][50][51][52][53][54] The lowest likelihood is in men participating in PSA 49 Consecutive biopsies at University College London Hospitals 1988-1994 1205 11…”

Section: Epidemiology Of Pinmentioning

confidence: 99%

“…Feneley et al (1997) 49 Consecutive biopsies of symptomatic men at St. Bartholomew's Hospital, London, 1993London, -1994 screening and early detection studies, with an incidence of PIN in biopsies ranging from 0.7 to 20%. [48][49][50][51][52][53][54] Men seen by urologists in practice have PIN in 4.4-25% of contemporary needle biopsies. Those undergoing transurethral resection have the highest likelihood of PIN, varying from 2.8 to 33% (Table 3).…”

Section: Epidemiology Of Pinmentioning

confidence: 99%

“…Other series have also found a high predictive value of PIN for cancer, although recent reports based on obtaining a greater number of cores shows a lower predictive value (Table 4). 51,[54][55][56][150][151][152][153][154][155][156][157][158] These data underscore the strong association of PIN and adenocarcinoma and indicate that vigorous diagnostic follow up is needed.…”

Section: Men With Pin Develop Prostate Cancermentioning

confidence: 99%

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High-grade prostatic intraepithelial neoplasia

Bostwick¹,

Qian²

2004

Mod Pathol

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High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be detected by current imaging techniques, including ultrasound. Most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

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Section: Epidemiology Of Pinmentioning

confidence: 99%

Section: Epidemiology Of Pinmentioning

confidence: 99%

Section: Men With Pin Develop Prostate Cancermentioning

confidence: 99%

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High-grade prostatic intraepithelial neoplasia

Bostwick¹,

Qian²

2004

Mod Pathol

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“…Recent studies showed that this biopsy protocol resulted in a positive detection rate of only 17-36%, 2,3 and that a significant number of patients (13-41%) with persistently elevated PSA after an initial negative biopsy had a positive repeat biopsy. [4][5][6][7][8] It has been sug-gested that alternative systematic biopsy schemes may result in increased prostate cancer detection rates.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a prostate biopsy strategy for cancer detection using a computer simulation system with virtual needle biopsy for three‐dimensional prostate models

et al. 2006

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Aim:We evaluated a prostate biopsy strategy for cancer detection using a computer simulation system with virtual needle biopsy for three-dimensional (3D) prostate models. Methods: Two 3D prostate models with a volume of 25 cc or 50 cc were constructed from computed tomographic images of radical prostatectomy specimens. The peripheral zone (PZ) and transition zone (TZ) were arranged in the prostate models according to the anatomical information. Four thousand patterns of cancer lesions were automatically inserted into each prostate model with a proportion of 75% in PZ and 25% in TZ. Average hit rates (AHR) in prostate models were evaluated both with an increased number of biopsy cores and various angles of virtual needle biopsy. The influence of adding secondary tumors for hit rates was also evaluated. Results: For both sizes, the laterally angled biopsy in 4-8 core biopsy schemes showed higher AHR than the vertical plane biopsy, while the vertical plane biopsy in 10-18 core biopsy schemes showed higher AHR than the laterally angled biopsy. A higher number of biopsy cores increased the AHR of secondary tumors. Conclusions: Our results suggest that it is important in prostate cancer detection to change the needle placement according to the number of biopsy cores and the size of the prostate.

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“…Regardless of the number of cores taken, it is important to follow‐up all negative biopsies in which there is a suspicion. Several variables can be followed in this cohort of patients, including PSA velocity [9,10].…”

mentioning

confidence: 99%