Results of Radiosurgical and Drug Treatment of Patients With Brain Metastases

Банов, С. М.; Golanov, Andrey; Ильялов, С. Р.; Ветлова, Елена; Маряшев, С. А.; Насхлеташвили, Д. Р.; Osinov, Ivan; Костюченко, В. В.; Дургарян, А. А.

doi:10.17650/2222-1468-2017-7-3-19-30

Opuholi golovy šei

2017

DOI: 10.17650/2222-1468-2017-7-3-19-30

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Results of Radiosurgical and Drug Treatment of Patients With Brain Metastases

С. М. Банов¹,

Andrey Golanov²,

С. Р. Ильялов³

et al.

Abstract: Цель исследованияизучение показателей общей выживаемости пациентов с метастазами в головной мозг и частоты интракраниальных рецидивов у них после проведения радиохирургии в самостоятельном варианте лечения. Материалы и методы. Проведен анализ результатов радиохирургического лечения 579 пациентов с метастазами в головной мозг (248 мужчин и 331 женщина). Источниками метастазирования в головной мозг были: рак молочной железы (164 пациента), немелкоклеточный рак легкого (162), меланома (123), рак почки (87), колор… Show more

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Cited by 4 publications

References 23 publications

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Staged radiosurgery of large brain metastasis with mass effect and brain dislocation: case report

Ilyalov¹,

Parshunina²,

Medvedeva³

et al. 2022

Nejrohirurgiâ (Mosk.)

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Introduction. Currently, one of the effective methods of treatment of intracranial metastases is stereotactic radiosurgery. The main factors limiting its use are the size (volume) of the tumor or the location of the metastasis in critical proximity to radiosensitive brain structures, such as the optic pathways, thalamus, brain stem, due to the high risk of developing local radiation necrosis. To reduce the risk of adverse radiation effects, hypofractionated radiotherapy by linac or staged Gamma Knife radiosurgery is used. However, large brain metastases that cause dislocation of the brain midline structures are traditionally considered an object for surgical excision, the main purpose of which is to eliminate the mass effect caused by the tumor.The objective of the publication: to demonstrate a case of successful application of staged Gamma Knife radiosurgery of large brain metastases accompanied by brain compression and dislocation.Materials and methods. Patient, 38‑year-old, with right-sided hemiplegia (0 score) and large (Ø = 3 cm, V = 12.9 cm3) breast cancer metastasis in the deep site of the left hemisphere, accompanied by severe perifocal edema and braindislocation (midline shift up to 15 mm). The treatment was carried out by Gamma Knife in two stages with an interval of 1.5 months.Results. As a result, not only a complete regression both of the perifocal edema and midline shift were noted, but also a significant decrease of the tumor volume and dramatical improvement in the patient’s neurological status already in the interval between the stages of radiosurgery: restoration of active movements in the right limbs (up to 4 score).Conclusion. This case demonstrates the possibility of effective and safe non-invasive treatment of large brain metastases accompanied by brain compression and dislocation, which makes it possible to achieve regression of the mass effect and improve the neurological quality of life of cancer patients.

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Staged radiosurgery of large brain metastasis with mass effect and brain dislocation: case report

Ilyalov¹,

Parshunina²,

Medvedeva³

et al. 2022

Nejrohirurgiâ (Mosk.)

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High-dose stereotactic radiosurgery for large brainstem metastasis and its recurrence treatment

Romanova¹,

Zubatkina²,

Ivanov

2023

Nejrohirurgiâ (Mosk.)

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Background. Breast cancer contributed to 11.8 % of all the oncological diseases detected in Russia in 2020 and to 21.7 % of tumors detected among women. The frequency of brain metastases is estimated at 13–32 %. It is known that HER2 positive and triple negative breast cancers metastasize to the brain more frequently.Aim. To present the case of stereotactic high‑dose irradiation for a large brainstem metastasis from HER2 positive breast cancer and re‑irradiation of the recurrence.Materials and methods. Analysis of the results of stereotactic irradiation for a large brainstem metastasis from HER2 positive breast cancer and re‑irradiation of the recurrence with a local control over five years was performed.Results. The local control after five years did not show any signs of tumor progression or post‑radiation necrosis. The patient’s Karnofsky Performance Status was estimated at 100 points.Conclusions. The case shows the necessity of highly conformal stereotactic dose delivery to the tumor, precise determination of tumor boundaries on high resolution thin slice magnetic resonance imaging, verification of recurrence using metabolic studies and hypofractionated dose delivery. It remains open whether and to what extent target therapy may contribute to local control.

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Modern strategies for the treatment of patients with kidney cancer of brain metastases: literature review

Рощина

Bekyashev

Насхлеташвили

et al. 2022

Opuholi golovy i šei

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According to the literature, metastatic brain damage in kidney cancer occurs in 6.5 % of patients. The introduction of new techniques associated with the use of targeted drugs, immune checkpoint inhibitors and innovative radiation therapy techniques can significantly increase patient survival. Effective drug therapy and local control of brain metastases are of paramount importance for predicting overall survival and quality of life for patients. This literature review summarizes the scientific literature data on the use of local and systemic methods of treatment in patients with metastases of kidney cancer to the brain.

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Results of Radiosurgical and Drug Treatment of Patients With Brain Metastases

Cited by 4 publications

References 23 publications

Staged radiosurgery of large brain metastasis with mass effect and brain dislocation: case report

Staged radiosurgery of large brain metastasis with mass effect and brain dislocation: case report

High-dose stereotactic radiosurgery for large brainstem metastasis and its recurrence treatment

Modern strategies for the treatment of patients with kidney cancer of brain metastases: literature review

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