Results of Methonium Treatment of Hypertensive Patients

The Medical Treatment of Essential Hypertension

“…These drugs have shown most promise in the treatment of hypertension in the premalignant and malignant stages of the disease. There is little doubt that they improve the prognosis of these cases and Smirk (1954), reported that of 28 patients with malignant hypertension, 21 were still living, the average survival time of these patients being 22.8 months. Although the association of headaches and anxiety is close, the disabling headaches of severe hypertension seem to have an organic basis, and their relief is one of the striking effects of the drugs.…”

“…Campbell and Robertson (1950), Turner (1950), Restall and Smirk (1950), Hill (1951), Campbell, Graham and Maxwell (1952) were among the first to use this drug therapeutically. Its value has been endorsed, particularly in the review of its action, by Morrison (1953), Harrington and Rosenheim (1954), Smirk (1954), and one of us with Maxwell (1954).…”

Comparison of Trimethidinium and Pempidine in Treatment of Severe Hypertension

“…The value of ganglion-blocking agents in the treatment of severe hypertension is well established (Smirk, 1954;Sears et al, 1959), but because of the frequency and severity of the side-effects they produce there is a constant search for effective drugs which can be used reliably by mouth and have a minimum of unwanted sideeffects. In this paper we describe our experience with two recently developed ganglion-blocking agents, trimethidinium and pempidine, and have tried to assess some of their advantages and drawbacks.…”