Results of intraperitoneal microdialysis depend on the location of the catheter

Abstract

In evaluating postoperative metabolism, intraperitoneal microdialysis is influenced by the location of the microdialysis catheter. The same pattern is, however, recorded over time. The juxta-anastomotic region and the small intestinal loop area seem to be the most reasonable locations for measurements.

Is Early Detection of Anastomotic Leakage Possible by Intraperitoneal Microdialysis and Intraperitoneal Cytokines After Anterior Resection of the Rectum for Cancer?

“…Similar differences in results depending on catheter location have been described in recent studies. 14 An interesting result was that intraperitoneal IL-6 and IL-10 were increased on both postoperative Days 1 and 2 in LEAK+ compared with LEAK-, whereas TNF-a was increased on postoperative Day 1 only. It is, however, unclear whether the higher levels in cytokine response in LEAK+ represent an early development of anastomotic leakage, or a different pattern of response to the surgical trauma, with a subsequent higher risk of later development of anastomotic leakage.…”

“…A larger study is therefore needed to define such limit values. In these comparisons, the patients with leakage while in the hospital, diagnosed on median Day 6 (range [2][3][4][5][6][7][8][9][10][11][12][13][14], were analyzed together with the patients who had leakage diagnosed after discharge from the hospital, on median Day 20 (range [18][19][20][21][22]. It may be argued that these two categories of leakages are too divergent to be analyzed as one group and that it may be more adequate to compare the LEAK-with the patients who had their leakage while in the hospital.…”

“…11,19 Glucose, lactate, and pyruvate can be safely monitored by intraperitoneal icrodialysis. 11,12,14,18 …”

Normal values and differences between intraperitoneal and subcutaneous microdialysis in patients after non‐complicated gastrointestinal surgery

“…Direct measurements from various abdominal organs show an evident variation [19,20] and the most appropriate location of a free-floating catheter in the abdominal cavity seems to be when it is embedded between the small-bowel loops [21]. Intraperitoneal lactate/pyruvate ratio differs considerably between cases with complications and those with a normal postoperative course [1].…”

Mediastinal microdialysis: early diagnosis of anastomotic leakage after resection for esophageal cancer

“…So far, the principle has been evaluated for intraperitoneal use. In animal studies and a few human studies, intraperitoneal microdialysis has been able to detect anastomotic bowel leakage before the development of signifi cant clinical symptoms [8][9][10][11][12][13][14][15]. The lactate/pyruvate ratio (L/P ratio) is the parameter with the highest sensitivity [15,16].…”