Results of interstitial HDR brachytherapy for cancer of the lower lip

Lebioda, Andrzej; Makarewicz, Roman; Terlikiewicz, Joanna; Wronczewska, Anna; Kabacińska, R.; Zuchora, Anysja

doi:10.1016/s1507-1367(05)71093-2

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…While the interstitial insertion of catheters was consistent among reported groups, treatment schedules varied. Physical prescribed doses are hard to compare, particularly among PDR-BT, LDR-BT, and HDR-BT [13,14,15,16,17,18,19,21]. Nevertheless, biologically effective doses were between 57-73 Gy (tumor α/β = 10 Gy), which was similar to our group (median, 65 Gy; range, 62-65 Gy).…”

Section: Discussionsupporting

confidence: 77%

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Adjuvant interstitial three-dimensional pulse-dose-rate-brachytherapy for lip squamous cell carcinoma after surgical resection

Chyrek

Bielęda

Burchardt

et al. 2019

jcb

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Purpose The purpose of this study was to report clinical outcomes of patients treated with pulse-dose-rate brachytherapy (PDR-BT) for lip cancer after insufficient surgery. Material and methods Twenty lip cancer patients were treated from January 2012 to September 2016. Primary treatment included surgery with or without reconstruction. All patients were diagnosed with squamous cell carcinoma, most of the tumors were pT1. Brachytherapy procedures were done after post-operative wound healing. Median of three plastic tubes were implanted using a free-hand technique. Two PDR-BT treatments were scheduled for every patient, with the gap of median 13 days. The planned dose was 0.8-1 Gy per pulse to the total dose of 50 Gy from two PDR-BT treatments. Patients were evaluated every 3-6 months. Follow-up time was counted from the last day of treatment to any event or last visit. Early and late toxicities were scored with RTOG scale. Results Average follow-up was 34.7 months (range, 12.7-67.6). Three- and five-year estimated disease-free survival was 95% and local control was 100%. One patient suffered from regional relapse in the submental region (IA lymph node group). Skin erythema or dry desquamation (grade 1) or wet desquamation (grade 2) was observed in 13 patients (65%) and one patient (5%), respectively. Six patients presented no acute toxicity. Moreover, there were no complications involving lip mucosa. All patients had grade 1 soft tissue fibrosis in the irradiated area, besides that, late toxicity included only skin complications. There were no significant factors associated with late toxicity ≥ grade 2. Conclusions PDR-BT in the adjuvant treatment of the lip cancer yields high local control with low toxicity. Even patients with close margins after surgery (< 5 mm) should be considered as candidates for PDR-BT.

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Section: Discussionsupporting

confidence: 77%

“…There are data available on brachytherapy regarding the treatment of lip cancer [13,14,15,16,17,18,19,20,21, 22,23]. Results reported in these studies are encouraging, with five-year local control of 77-100%, and mostly good cosmetic outcomes and no grade 4 late toxicities.…”

Section: Purposementioning

confidence: 99%

Adjuvant interstitial three-dimensional pulse-dose-rate-brachytherapy for lip squamous cell carcinoma after surgical resection

Chyrek

Bielęda

Burchardt

et al. 2019

jcb

View full text Add to dashboard Cite

show abstract

“…We achieved a local control rate of 90% in a former study from our hospital with low‐dose‐rate (LDR) brachytherapy, including 28% of T3 to T4 lip carcinomas . Publications on the treatment of lip carcinoma through high‐dose‐rate (HDR) brachytherapy are scarce and have a short follow‐up as well …”

Section: Introductionmentioning

confidence: 99%

“…21 Publications on the treatment of lip carcinoma through high-dose-rate (HDR) brachytherapy are scarce and have a short follow-up as well. [22][23][24][25][26] Regarding nodal treatment, a neck dissection is mandatory when clinical nodes are detected. The disease control is directly related to the nodal size.…”

Section: Introductionmentioning

confidence: 99%