Results of Heterologous Insemination at the University of Berne Gynecology Clinic

Genetic Issues in Artificial Insemination by Donor

“…Forse and colleagues 38 also noted a higher rate of nonchromosomal abnormalities (3.8%) in AID offspring compared with such findings in the general population (1.7%). 57 In contrast, CECOS' rate of 1.4% for nonchromosomal abnormalities 2 is not elevated, nor do the combined data of a number of other studies indicate an increased risk 18,20,[32][33][34][35][36][37][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] (see Table 7).…”

“…It is also reasonable, however, although not obligatory, to offer amniocentesis or ultrasound examination for prenatal diagnosis. 2,39,54 Many couples will refuse invasive testing, Table 7. Anomalies in AID Pregnancies* Author Behrman 33 Bromwichetal 34 Chong and Taymor 35 Corson 36 David and Avidan 37 Fédération CECOS et al 2 Forse et al 38 † Gigon and Haldemann 39 Glezerman 40 Haman 41 Katzorkeetal 42 Kleegman 43 Koren and Lieberman 44 Kovas and Lording 45 Langer et al 46 Lebech and Detlefsen 47 Leeton and Blackwell 48 Macourt and Jones 49 Newill 50 Raboch and Tomášek 51 Schoysman-Deboeck and Schoysman…”

“…As an alternative to karyotyping all donors and recipients, Gigon and Haldemann 39 have suggested karyotyping (by amniocentesis) all fetuses conceived by AID. This approach recognizes that most chromosomal abnormalities are not inherited from a parent but rather occur de novo.…”