Results of Hepatic Resection for Liver Metastasis of Gastric Cancer

Nishi, Masaaki; Shimada, Mistuo; Yoshikawa, Kozo; Higashijima, Jun; Tokunaga, Takuya; Kashihara, Hideya; Takasu, Chie; Ishikawa, Daichi; Wada, Yuma; Eto, Shohei

doi:10.2152/jmi.65.27

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…However, the presence of a considerable proportion of patients alive at 5 years (range, 16.3%-33.3%)[ 4 , 34 , 44 ] who had undergone resection for synchronous metastases has in part changed this attitude to date. Although there is currently no strong evidence of a better prognosis for synchronous metastases, many studies[ 17 , 40 , 45 ] in the last few years have not reported significant differences in OS when comparing synchronous vs. metachronous metastases. It is a sign that, at the current state of knowledge, the presence of synchronous metastases need not be considered a condition without any surgical options.…”

Section: Resultsmentioning

confidence: 99%

Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?

Uggeri

Ripamonti

Pinotti

et al. 2020

WJCO

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BACKGROUND Distant metastases are found in approximately 35% of patients with gastric cancer at their first clinical observation, and of these, 4%-14% involves the liver. Unfortunately, only 0.4%-2.3% of patients with metastatic gastric cancer are eligible for radical surgery. Although surgical resection for gastric cancer metastases is still debated, there have been changes in recent years, although several clinical issues remain to be defined and that must be taken into account before surgery is proposed. AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer. METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The study protocol was based on identifying studies with clearly defined purpose, eligibility criteria, methodological analysis, and patient outcome. RESULTS We selected 47 studies pertaining to the purpose of the review, which involved a total of 2304 patients. Median survival was 7-52.3 mo, median disease-free survival was 4.7-18 mo. The 1-, 2-, 3-, and 5-year overall survival (OS) was 33%-90.1%, 10%-60%, 6%-70.4%, and 0%-40.1%, respectively. Only five papers reported the 10-year OS, which was 5.5%–31.5%. The general recurrence rate was between 55.5% and 96%, and that for hepatic recurrence was between 15% and 94%. CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis, while the presence of single metastasis or ≤ 3 metastases associated with a size of < 5 cm may be considered data that do not contraindicate liver resection.

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Section: Resultsmentioning

confidence: 99%

Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?

Uggeri

Ripamonti

Pinotti

et al. 2020

WJCO

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“…The emergence of CT and MRI has had a far-reaching impact on surgery and even the whole medical area. The ability to “see” gives surgeons an ideal space for display [ 10 ]. New imaging technology, which requires not only “seeing clearly” but also “seeing well” and has the function of virtual operation, has become another essential technical demand in the field of liver surgery in the new era [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Application of the Preoperative Assistant System Based on Machine Learning in Hepatocellular Carcinoma Resection

et al. 2021

Journal of Healthcare Engineering

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To conduct better research in hepatocellular carcinoma resection, this paper used 3D machine learning and logistic regression algorithm to study the preoperative assistance of patients undergoing hepatectomy. In this study, the logistic regression model was analyzed to find the influencing factors for the survival and recurrence of patients. The clinical data of 50 HCC patients who underwent extensive hepatectomy (≥4 segments of the liver) admitted to our hospital from June 2020 to December 2020 were selected to calculate the liver volume, simulated surgical resection volume, residual liver volume, surgical margin, etc. The results showed that the simulated liver volume of 50 patients was 845.2 + 285.5 mL, and the actual liver volume of 50 patients was 826.3 ± 268.1 mL, and there was no significant difference between the two groups (t = 0.425; P > 0.05). Compared with the logistic regression model, the machine learning method has a better prediction effect, but the logistic regression model has better interpretability. The analysis of the relationship between the liver tumour and hepatic vessels in practical problems has specific clinical application value for accurately evaluating the volume of liver resection and surgical margin.

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“…Primary tumor No serosal invasion (40,66) Lower T stage (33,49,65,67,78,79) No lymphatic or venous invasion (46,55,72,79) Liver metastases Unilobar involvement (26,47,61,73,78,81) Number of metastatic lesions ≤ 3, especially for solitary metastasis (30, 35, 40, 41, 46, 52-56, 61-63, 65, 69-72) Diameter of greatest lesion ≤ 5 cm (36,40,43,53,66,68) Metachronous metastases (27,51,54,62,67) Extrahepatic metastasis Absence of peritoneal metastasis (38,39,44 which could remove the tumor and retain tissues to the hilt. Simultaneously, neoadjuvant chemotherapy was able to treat micrometastases at an early stage to downstage the primary tumor and obtained a higher R0 resection rate.…”

Section: Categories Favorable Prognostic Factors Referencesmentioning

confidence: 99%

Surgery Strategies for Gastric Cancer With Liver Metastasis

2019

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Gastric cancer with liver metastasis is defined as advanced gastric cancer and remains one of the deadliest diseases with poor prognosis. Approximately 4-14% of patients with gastric cancers presented with liver metastases at the initial diagnosis. Owing to its incurability, first-line treatment for gastric cancer with liver metastases is systematic chemotherapy, whereas surgery is usually performed to alleviate severe gastrointestinal symptoms. However, continuously emerging retrospective studies confirmed the role of surgery in gastric cancer with liver metastases and showed significantly improved survival rate in patients assigned to a group of surgery with or without chemotherapy. Therefore, more and more convincing data that resulted from prospective randomized clinical trials is in need to clarify the surgery strategies in patients with gastric cancer with liver metastasis.

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Results of Hepatic Resection for Liver Metastasis of Gastric Cancer

Abstract: Hepatic resection for GLM has an acceptable outcome. Metachronous hepatic resection tends to have a better outcome than synchronous hepatic resection for the treatment of GLM. J. Med. Invest. 65:27-31, February, 2018.

Cited by 9 publications

References 13 publications

Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?

Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?

Application of the Preoperative Assistant System Based on Machine Learning in Hepatocellular Carcinoma Resection

Surgery Strategies for Gastric Cancer With Liver Metastasis

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