Results of extensive surgery for liver metastases in colorectal carcinoma

Nakamura, Satoshi; Yokoi, Yoshihiro; Suzuki, Shohachi; Baba, Shigeaki; Muro, Hiroyuki

doi:10.1002/bjs.1800790112

Cited by 113 publications

(63 citation statements)

References 19 publications

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“…Out of these, 860 studies were excluded because of the exclusion criteria. Eleven reports of ten studies qualified for the review [7, 8, 15–17, 18, 25, 28, 29, 35, 37]. The duplicate report [16, 25] was identified by using the common author and centre.…”

Section: Resultsmentioning

confidence: 99%

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

2008

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Background. Hepatic lymph node involvement is generally considered a contraindication for liver resection performed for colorectal liver metastases. However, some advocate hepatic lymphadenectomy in the presence of macroscopic involvement and others routine lymphadenectomy. The aim of this review is to assess the role of lymphadenectomy in resection of liver metastases from colorectal cancer. Methods. Medline, Embase and Central databases were searched using a formal search strategy. Trials with survival data with a minimum follow-up of 1 year were considered for inclusion. Meta-analysis was performed using Revman. Results. A total of 4230 references were identified. Ten reports of nine studies including 926 patients qualified for the review. The prevalence of nodal metastases after routine lymphadenectomy was 16.3%. The overall 3-year and 5-year survival rates in node-positive patients were 9/151 (11.3%) and 2/137 (1.5%), respectively, compared to 3-year and 5-year survival rates of 424/787 (53.9%) and 246/767 (32.1%) in node-negative patients. The odds ratios for 3-year and 5-year survivals in node positive disease compared to node-negative disease were 0.12 (95% CI 0.06 to 0.24) and 0.08 (95% CI 0.03 to 0.22). There was no randomized controlled trial which assessed the survival benefit of routine or “selective” lymphadenectomy. Conclusion. Currently, there is no evidence of survival benefit for routine or selective lymphadenectomy. Survival rates are low in patients with positive lymph nodes draining the liver irrespective of whether they are detected by routine lymphadenectomy or by macroscopic involvement. Further trials in this patient group are required.

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Section: Resultsmentioning

confidence: 99%

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

2008

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“…The rate of microscopic involvement of hepatic lymph nodes has been reported to be 11% to 28%. [22][23][24][25][26][27][28] Although hepatectomy and lymph node dissection were performed in these patients, 5-year survival was reportedly 0% to 5%. 24,25,28 Rodgers and McCall 29 reviewed 15 studies that gave survival data on node-positive patients: 145 patients received hepatic resection, and only 5 (3.4%) survived 5 years.…”

Section: Commentmentioning

confidence: 99%

Simplified Staging System for Predicting the Prognosis of Patients With Resectable Liver Metastasis

Minagawa

Yamamoto²,

Kosuge³

et al. 2007

Arch Surg

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“…Despite a certain amount of controversy, some authors have reported significant survival rates in liver-metastasis patients with associated hilar-lymph-node disease who undergo combined liver resection and lymphadenectomy (7,9,16,17,25) . Among those results, Kokudo et al (19) have shown that the survival rate of patients with lymph node disease who undergo curative resection and lymphadenectomy is significantly higher than that of residual-liver-disease patients without lymph-node metastases who undergo liver resection (17 months versus 8 months, P<0.05).…”

Section: Introductionmentioning

confidence: 99%

The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis

Viana

Herman

Coelho

et al. 2011

Arq. Gastroenterol.

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-Context -Hepatectomy is the treatment of choice for colorectal liver metastases, and several studies have shown good results, with 5-year survival rates ranging from 40% to 57%. Several clinical and pathological predictive factors for survival after liver resection have been studied. Involvement of the hepatic hilum lymph nodes, the incidence of which varies from 2% to 10%, indicates a poor long-term prognosis. Results -Despite variable results, some authors have reported a not-insignificant improvement in survival rate in liver-metastasis patients with hilar lymph node involvement who undergo combined liver resection and lymphadenectomy. Due to the low rates of morbidity and mortality for liver-resection surgery, several specialized centers perform liver resections combined with lymphadenectomies in selected cases. It should be noted that the therapeutic value of systemic lymphadenectomy is not yet entirely understood, and only controlled studies comparing groups with and without lymphadenectomy can fully resolve the issue. Conclusion -In any case, hilar lymph node dissection has been shown to be a useful tool for improving the accuracy of extra hepatic disease staging, regardless of its impact on survival. HEADINGS -Neoplasm metastasis. Lymph node excision. Hepatectomy. Colorectal neoplasms.

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Results of extensive surgery for liver metastases in colorectal carcinoma

Cited by 113 publications

References 19 publications

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

Management of the Hepatic Lymph Nodes during Resection of Liver Metastases from Colorectal Cancer: A Systematic Review

Simplified Staging System for Predicting the Prognosis of Patients With Resectable Liver Metastasis

The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis

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