Results of esophagectomy for esophageal cancer in elderly patients: Age has little influence on outcome and survival

Ruol, Alberto; Portale, Giuseppe; Zaninotto, Giovanni; Cagol, Matteo; Cavallin, Francesco; Castoro, Carlo; Chiarion-Sileni, Vanna; Alfieri, Rita; Rampado, Sabrina; Ancona, Ermanno

doi:10.1016/j.jtcvs.2006.12.040

Cited by 130 publications

(134 citation statements)

References 15 publications

(16 reference statements)

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“…In several studies, the influence of old age was investigated [44][45][46][47][48][49][50][51][52][53][54][55][56] . In a minority of studies, older age was associated with an unfavourable postoperative outcome 44;49;52;53;55;56. The use of a risk score may be a quality indicator.…”

Section: Patient Selectionmentioning

confidence: 99%

Quality-of-care indicators for oesophageal cancer surgery: A review

Staal

Wouters

Boot

et al. 2010

European Journal of Surgical Oncology

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Section: Patient Selectionmentioning

confidence: 99%

Quality-of-care indicators for oesophageal cancer surgery: A review

Staal

Wouters

Boot

et al. 2010

European Journal of Surgical Oncology

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“…However, the most relevant treatment modalities in elderly patients with EC remain a subject of debate. It was reported that elderly patients are less likely to undergo surgery and chemotherapy, which is partially due to their comorbidities (3,4). Currently, CRT based on the 5-fluorouracil-cisplatin (5FU-CDDP) regimen is used for the treatment with curative intent of locally advanced or inoperable non-metastatic EC (5).…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term outcomes of definitive chemoradiotherapy in patients with esophageal carcinoma aged ≥75 years

Liu

Wang

et al. 2013

Molecular and Clinical Oncology

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Abstract. The most relevant treatment modalities in elderly patients with esophageal carcinoma (EC) remain a subject of debate. Combined definitive chemoradiotherapy (CRT) is currently widely accepted as a non-surgical treatment for esophageal cancer. However, elderly patients were excluded from the majority of studies on CRT, or the proportion of elderly patients was relatively low in those studies and the number of available studies on the treatment of EC patients aged ≥75 years is limited. The aim of the present retrospective study was to analyze the safety and efficacy of CRT in patients aged ≥75 years in order to assess the short-and long-term outcomes of CRT for elderly patients with EC. In this study, based on further refinement of patient age groups and analysis of the Charlson comorbidity score, we performed a statistical analysis of factors such as short-term response, long-term survival and toxicity reactions. The results of the analysis indicated that the treatment of patients with EC aged ≥75 years with radiotherapy (RT) and chemotherapy was effective. However, we recommend that customized treatment is based on the stratification of patients into different age groups and the Charlson score, as for patients aged ≥80 years a lower-dose therapy may be more beneficial and for patients aged ≥85 years definitive CRT should be administered with greater caution.

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“…Therefore, advanced age alone may not exclude esophagectomy for patients with esophageal cancer. [18] Impaired preoperative pulmonary function has long been considered as an important tool for the evaluation of the risk of PCs after esophagectomy. [3,19,20] Avendano et al [19] and Shiozaki et al [20] reported that preoperative FEV 1 % less than 65% and 60% were associated with increased PCs after esophagectomy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of a predictive score for pulmonary complications in cancer patients after esophagectomy

Xing¹,

Gao²,

Wang³

et al. 2016

World Journal of Emergency Medicine

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BACKGROUND: Esophagectomy is a very important method for the treatment of resectable esophageal cancer, which carries a high rate of morbidity and mortality. This study was undertaken to assess the predictive score proposed by Ferguson et al for pulmonary complications after esophagectomy for patients with cancer. METHODS:The data of patients who admitted to the intensive care unit after transthoracic esophagectomy at Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College between September 2008 and October 2010 were retrospectively reviewed. RESULTS:Two hundred and seventeen patients were analyzed and 129 (59.4%) of them had postoperative pulmonary complications. Risk scores varied from 0 to 12 in all patients. The risk scores of patients with postoperative pulmonary complications were higher than those of patients without postoperative pulmonary complications (7.27±2.50 vs. 6.82±2.67; P=0.203). There was no significant difference in the incidence of postoperative pulmonary complications as well as in the increase of risk scores (χ 2 =5.477, P=0.242). The area under the curve of predictive score was 0.539±0.040 (95%CI 0.461 to 0.618; P=0.324) in predicting the risk of pulmonary complications in patients after esophagectomy. CONCLUSION:In this study, the predictive power of the risk score proposed by Ferguson et al was poor in discriminating whether there were postoperative pulmonary complications after esophagectomy for cancer patients.

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Results of esophagectomy for esophageal cancer in elderly patients: Age has little influence on outcome and survival

Cited by 130 publications

References 15 publications

Quality-of-care indicators for oesophageal cancer surgery: A review

Quality-of-care indicators for oesophageal cancer surgery: A review

Short- and long-term outcomes of definitive chemoradiotherapy in patients with esophageal carcinoma aged ≥75 years

Assessment of a predictive score for pulmonary complications in cancer patients after esophagectomy

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